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Chemical Structure| 1186127-11-6 Chemical Structure| 1186127-11-6

Structure of 1186127-11-6

Chemical Structure| 1186127-11-6

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Product Details of [ 1186127-11-6 ]

CAS No. :1186127-11-6
Formula : C18H34BNO3Si
M.W : 351.36
SMILES Code : CC([Si](C1=NC=C(B2OC(C)(C)C(C)(C)O2)O1)(C(C)C)C(C)C)C
MDL No. :MFCD16170324
InChI Key :QHQHHUIEVWSWDJ-UHFFFAOYSA-N
Pubchem ID :44224311

Safety of [ 1186127-11-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 1186127-11-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1186127-11-6 ]

[ 1186127-11-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1186127-11-6 ]
  • [ 160976-02-3 ]
  • [ 1400706-90-2 ]
YieldReaction ConditionsOperation in experiment
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate; In 1,4-dioxane; methanol; at 80℃;Inert atmosphere; A 2 M aqueous Na2CO3 solution (1 .51 mL) is added to a mixture of 5-bromo-1 ,3- difluoro-2-iodo-benzene (1 .00 g) and 5-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)- 2-triisopropylsilanyl-oxazole (1 .87 g) in 1 ,4-dioxane (9 mL) and methanol (3 mL). The mixture is sparged with argon and [1 ,1 '-bis(diphenylphosphino)-ferrocene]dichloro- palladium dichloromethane complex (380 mg) is added. The resulting mixture is stirred at 80C overnight. Since the conversion is not complete, the same amounts of 5-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-2-triisopropylsilanyl-oxazole, 2 M aqueous Na2CO3 solution, and catalyst are added and the mixture is again stirred overnight at 80C. The triisopropylsilyl protecting group is cleaved under these conditions. After cooling to room temperature, ethyl acetate and water are added. The aqueous phase is extracted with ethyl acetate and the combined organic phases are washed with brine, dried over MgSO4, and concentrated in vacuo. The residue is chromatographed on silica gel (cyclohexane/ethyl acetate 1 :0? 1 :1 ) to afford the title compound. LC (method 4): tR = 1 .18 min; Mass spectrum (ESI+): m/z = 260/262 (Br) [M+H]+.
 

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