117997-81-6|5-(Benzyloxy)-2-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid| Ambeed

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Quality Control of [ 117997-81-6 ] Purity: 97% SDS Specification

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Product Details of [ 117997-81-6 ]

CAS No. :	117997-81-6
Formula :	C₁₇H₂₃NO₆
M.W :	337.37
SMILES Code :	O=C(O)C(NC(OC(C)(C)C)=O)CCC(OCC1=CC=CC=C1)=O
MDL No. :	MFCD00798612
InChI Key :	AJDUMMXHVCMISJ-UHFFFAOYSA-N
Pubchem ID :	295483

Safety of [ 117997-81-6 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 117997-81-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 117997-81-6 ]

[ 117997-81-6 ] Synthesis Path-Downstream 1~35

1
[ 117997-81-6 ]
2-[2-Amino-3-(diphenoxy-phosphoryloxy)-propionylamino]-methyl}-3-methyl-butyric acid benzyl ester; compound with trifluoro-acetic acid [ No CAS ]
[ 105751-09-5 ]

References: [1]Tetrahedron Letters,1986,vol. 27,p. 1373 - 1376.

2
[ 117997-81-6 ]
[ 95656-84-1 ]

References: [1]Organic Letters,2014,vol. 16,p. 4228 - 4231.
[2]Journal of the Chemical Society. Chemical communications,1984,p. 1298 - 1299.

3
[ 117997-81-6 ]
[ 2050-92-2 ]
[ 118100-26-8 ]

References: [1]Journal of Medicinal Chemistry,1990,vol. 33,p. 591 - 595.

4
[ 100-02-7 ]
[ 117997-81-6 ]
4-nitrophenyl γ-benzyl-N-tert-butoxycarbonylglutamate [ No CAS ]

References: [1]Collection of Czechoslovak Chemical Communications,1995,vol. 60,p. 1765 - 1780.

5
[ 24424-99-5 ]
[ 29456-09-5 ]
[ 117997-81-6 ]

References: [1]Collection of Czechoslovak Chemical Communications,1995,vol. 60,p. 1765 - 1780.
[2]New Journal of Chemistry,2019,vol. 43,p. 12109 - 12117.

6
[ 117997-81-6 ]
lysine benzyl ester bis(trifluoroacetate) [ No CAS ]
N,N'-bis(tert-butoxycarbonyl-γ-benzylglutamyl)lysine benzyl ester [ No CAS ]

References: [1]Collection of Czechoslovak Chemical Communications,1995,vol. 60,p. 1765 - 1780.

7
[ 117997-81-6 ]
N,N'-bis(phenylalanyl)ethylenediamine bis(trifluoroacetate) [ No CAS ]
[ 122262-04-8 ]

References: [1]Collection of Czechoslovak Chemical Communications,1995,vol. 60,p. 1765 - 1780.

8
[ 117997-81-6 ]
[ 104-15-4 ]
H-Glu(OBzl)-OH p-toluenesulfonic acid salt [ No CAS ]

References: [1]Synthetic Communications,2005,vol. 35,p. 1795 - 1802.

9
[ 93578-22-4 ]
[ 117997-81-6 ]
4-(6-allyl-benzo[1,3]dioxol-5-ylcarbamoyl)-4-<i>tert</i>-butoxycarbonylamino-butyric acid benzyl ester [ No CAS ]

References: [1]European Journal of Medicinal Chemistry,2004,vol. 39,p. 1059 - 1065.

10
[ 117997-81-6 ]
N,N'-bis(tert-butoxycarbonyl-γ-benzylglutamyl)ethylenediamine [ No CAS ]

References: [1]Collection of Czechoslovak Chemical Communications,1995,vol. 60,p. 1765 - 1780.

11
[ 117997-81-6 ]
N,N'-bis(γ-benzylglutamyl)ethylenediamine bis(trifluoroacetate) [ No CAS ]

References: [1]Collection of Czechoslovak Chemical Communications,1995,vol. 60,p. 1765 - 1780.

12
[ 117997-81-6 ]
N,N'-bis(tert-butoxycarbonylphenylalanyl-γ-benzylglutamyl)ethylenediamine [ No CAS ]

References: [1]Collection of Czechoslovak Chemical Communications,1995,vol. 60,p. 1765 - 1780.

13
[ 117997-81-6 ]
N,N'-bis(γ-benzylglutamyl)lysine benzyl ester bis(trifluoroacetate) [ No CAS ]

References: [1]Collection of Czechoslovak Chemical Communications,1995,vol. 60,p. 1765 - 1780.

14
[ 117997-81-6 ]
N,N'-bis(phenylalanyl-γ-benzylglutamyl)ethylenediamine bis(trifluoroacetate) [ No CAS ]

References: [1]Collection of Czechoslovak Chemical Communications,1995,vol. 60,p. 1765 - 1780.

15
[ 117997-81-6 ]
N,N'-bis(γ-benzylglutamylphenylalanyl)ethylenediamine bis(trifluoroacetate) [ No CAS ]

References: [1]Collection of Czechoslovak Chemical Communications,1995,vol. 60,p. 1765 - 1780.

16
[ 117997-81-6 ]
[ 105751-06-2 ]

References: [1]Tetrahedron Letters,1986,vol. 27,p. 1373 - 1376.
[2]Tetrahedron Letters,1986,vol. 27,p. 1377 - 1380.

17
[ 117997-81-6 ]
[ 105751-11-9 ]

References: [1]Tetrahedron Letters,1986,vol. 27,p. 1373 - 1376.

18
[ 117997-81-6 ]
[ 117997-60-1 ]

References: [1]Journal of Medicinal Chemistry,1990,vol. 33,p. 591 - 595.

19
[ 117997-81-6 ]
[ 123540-70-5 ]

References: [1]Journal of Medicinal Chemistry,1990,vol. 33,p. 591 - 595.

20
[ 117997-81-6 ]
[ 123540-71-6 ]

References: [1]Journal of Medicinal Chemistry,1990,vol. 33,p. 591 - 595.

21
[ 117997-81-6 ]
[ 117997-61-2 ]

References: [1]Journal of Medicinal Chemistry,1990,vol. 33,p. 591 - 595.

22
[ 117997-81-6 ]
[ 118100-27-9 ]

References: [1]Journal of Medicinal Chemistry,1990,vol. 33,p. 591 - 595.

23
[ 117997-81-6 ]
[ 18807-74-4 ]
Boc-Glu(OBzl)-NH(CH₂)5-NH-Z [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
94%	With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20℃; for 27h;	To a solution of <strong>[117997-81-6]Boc-Glu(OBzl)-OH</strong> (0.30 g, 0.90 mmol) and N-Z-1,5-pentanediamine hydrochloride (0.24 g, 0.90 mmol) in DMF (10 mL) at 0 C. were added NMM (0.10 mL, 0.90 mmol), HOBt (0.15 g, 0.99 mmol) and WSC (0.19 g, 0.99 mmol). Z is the protecting group benzyloxycarbonyl. The reaction mixture was stirred for 3 h at 0 C. and for 24 h at room temperature. After DMF was evaporated, the residue was solubilized in EtOAc and washed with citric acid (10%), NaHCO3 (5%), and brine. The organic phase was dried and evaporated to dryness. The residue was crystallized from Et2O/Pe (1:9, v/v): yield 0.47 g (94%); Rf (B) 0.94; HPLC K'=9.15; mp 141-143 C.; [α]20D+20.4; MH+ 556; 1H NMR (DMSO) δ 1.29-1.55 (m, 15 H), 2.18-2.25 (m, 4H), 2.96-3.20 (m, 4H), 4.53-5.34 (m, 5H), 7.11-7.29 (m, 10H).

References: [1]Patent: US2006/104907,2006,A1 .Location in patent: Page/Page column 7.

24
[ 5202-89-1 ]
[ 117997-81-6 ]
methyl 2-(5-(benzyloxy)-2-(tert-butoxycarbonylamino)-5-oxopentanamido)-5-chlorobenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
41%		(i) Methyl 2-(5-(benzyloxy)-2-(tert-butoxycarbonylamino)-5-oxopentanamido)-5-chlorobenzoateAfter adding 4.0 g (11.9 mmol) of DL-<strong>[117997-81-6]Boc-Glu(OBzl)-OH</strong> to acetonitrile, 2.9 g (35.6 mmol) of N-methyl imidazole and 2.7 g (14.2 mmol) of p-toluene sulfonyl chloride were added and stirring for 1 hour at 0 C. Subsequently, 2.2 g (11.9 mmol) of methyl 2-amino-5-chlorobenzoate was added, and the mixture was stirred at room temperature overnight. After concentration, the reaction mixture was diluted with ethyl acetate, and washed with water. After drying the resulting organic layer over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure. The crude product obtained was separated and purified by silica gel column chromatography to give 2.5 g of methyl 2-(5-(benzyloxy)-2-(tert-butoxycarbonylamino)-5-oxopentanamido)-5-chlorobenzoate (yield 41%).1H-NMR (CDCl3) δ: 1.46 (9H, s), 1.95-2.15 (1H, m), 2.23-2.43 (1H, m), 2.49-2.62 (2H, m), 3.92 (3H, s), 4.26-4.45 (1H, m), 5.13 (2H, s), 5.35 (1H, d, J=8.2 Hz), 7.29-7.42 (5H, m), 7.49 (1H, dd, J=9.2, 2.6 Hz), 8.00 (1H, d, J=2.6 Hz), 8.69 (1H, d, J=9.2 Hz), 11.5 (1H, s).

References: [1]Patent: US2009/124620,2009,A1 .Location in patent: Page/Page column 46.

25
[ 4556-23-4 ]
[ 117997-81-6 ]
C₂₂H₂₆N₂O₅S [ No CAS ]

References: [1]Organic Letters,2010,vol. 12,p. 4716 - 4719.

26
[ 117997-81-6 ]
[ 62-53-3 ]
[ 126349-57-3 ]

Yield	Reaction Conditions	Operation in experiment
94%		To a stirred solution of Boc-L-glutamic acid 5-benzyl ester [4a] (41 g, 122 mmol) in anhydrous CH2Cl2 (45 ml) at O0C, was added during 15 minutes a solution of DCC (30.1 g, 146 mmol) in anhydrous CH2Cl2 (45 ml). The resulting white solid was sonicated. After that, anhydrous aniline was added dropwise to the reaction mixture over 10 minutes at O0C (11.1 ml, 122 mmol). The mixture was stirred at room temperature for 40 minutes and filtered through Celite to remove insoluble material. The resulting liquid was evaporated to dryness and chromatographically purified, yielding the desired product (47.2 g, 94%).1H-NMR (400 MHz, CDCl3): δ: 8.40 (br, IH, CONHPh), 7.43 (d, 2H, J=7.7 Hz, 2Ha), 7.28 (d, 2H, J=7.7 Hz, Hb), 7.20 (m, 5H, 5xHd), 7.02 (t, IH, J=7.4 Hz, Hc), 5.35 (d, IH, J=7.8 Hz, CHNHBoc), 5.04 (d, 2H, J=2.6 Hz, BnOCH2), 4.26 (sa, IH, CH2CHNHBoC), 2.60-2.52 (me, IH, IxOCOCH2CH2), 2.46-2.38 (me, IH, Ix OCOCH2CH2), 2.21-2.12 (me, IH, IxOCOCH2CH2), 1.99-1.90 (me, IH, Ix OCOCH2CH2), 1.40 (s, 9H, MS: Positive mode [M + Na]+ = 435.MS: Negative mode [M + 2 H2O - H]- = 447.
94%		Example 1 Preparation of intermediate [6a]: Benzyl 4-(tert-butoxycarbonylamino)-5-oxo-5-(phenylamino) pentanoate To a stirred solution of Boc-L-glutamic acid 5-benzyl ester [4a] (41 g, 122 mmol) in anhydrous CH2Cl2 (45 ml) at 0C, was added during 15 minutes a solution of DCC (30.1 g, 146 mmol) in anhydrous CH2Cl2 (45 ml). The resulting white solid was sonicated. After that, anhydrous aniline was added dropwise to the reaction mixture over 10 minutes at 0C (11.1 ml, 122 mmol). The mixture was stirred at room temperature for 40 minutes and filtered through Celite to remove insoluble material. The resulting liquid was evaporated to dryness and chromatographically purified, yielding the desired product (47.2 g, 94%). 1H-NNM (400 MHz, CDCl3): δ: 8.40 (br, 1H, CONHPh), 7.43 (d, 2H, J=7.7 Hz, 2Ha), 7.28 (d, 2H, J=7.7 Hz, Hb), 7.20 (m, 5H, 5xHd), 7.02 (t, 1H, J=7.4 Hz, Hc), 5.35 (d, 1H, J=7.8 Hz, CHNHBoc), 5.04 (d, 2H, J=2.6 Hz, BnOCH2), 4.26 (sa, 1H, CH2CHNHBOC), 2.60-2.52 (mc, 1H, 1xOCOCH2CH2), 2.46-2.38 (mc, 1H, 1x OCOCH2CH2), 2.21-2.12 (mc, 1H, 1xOCOCH2CH2), 1.99-1.90 (mc, 1H, 1x OCOCH2CH2), 1.40 (s, 9H, NHCO2C(CH3)3) ppm. MS: Positive mode [M + Na]+ = 435. MS: Negative mode [M + 2 H2O - H]- = 447. CAS nr: [126349-57-3]
94%		To a stirred solution of Boc-L-glutamic acid 5-benzyl ester [4a] (41 g, 122 mmol) in anhydrous CH2Cl2 (45 ml) at 0C, was added during 15 minutes a solution of DCC (30.1 g, 146 mmol) in anhydrous CH2Cl2 (45 ml). The resulting white solid was sonicated. After that, anhydrous aniline was added dropwise to the reaction mixture over 10 minutes at 0C (11.1 ml, 122 mmol). The mixture was stirred at room temperature for 40 minutes and filtered through Celite to remove insoluble material. The resulting liquid was evaporated to dryness and chromatographically purified, yielding the desired product (47.2 g, 94%). 1H-NMR (400 MHz, CDCl3): δ: 8.40 (br, 1H, CONHPh), 7.43 (d, 2H, J=7.7 Hz, 2Ha), 7.28 (d, 2H, J=7.7 Hz, Hb), 7.20 (m, 5H, 5xHd), 7.02 (t, 1H, J=7.4 Hz, Hc), 5.35 (d, 1H, J=7.8 Hz, CHNHBoc), 5.04 (d, 2H, J=2.6 Hz, BnOCH2), 4.26 (sa, 1H, CH2CHNHBoc), 2.60-2.52 (mc, 1H, 1xOCOCH2CH2), 2.46-2.38 (mc, 1H, 1x OCOCH2CH2), 2.21-2.12 (mc, 1H, 1xOCOCH2CH2), 1.99-1.90 (mc, 1H, 1x OCOCH2CH2), 1.40 (s, 9H, NHCO2C(CH3)3) ppm. MS: Positive mode [M + Na]+ = 435. MS: Negative mode [M + 2 H2O - H]- = 447. CAS nr: [126349-57-3]

94%		To a stirred solution of Boc-L-glutamic acid 5-benzyl ester [4a] (41 g, 122 mmol) in anhydrous CH2Cl2 (45 ml) at 0 C., was added during 15 minutes a solution of DCC (30.1 g, 146 mmol) in anhydrous CH2Cl2 (45 ml). The resulting white solid was sonicated. After that, anhydrous aniline was added dropwise to the reaction mixture over 10 minutes at 0 C. (11.1 ml, 122 mmol). The mixture was stirred at room temperature for 40 minutes and filtered through Celite to remove insoluble material. The resulting liquid was evaporated to dryness and chromatographically purified, yielding the desired product (47.2 g, 94%).1H-NMR (400 MHz, CDCl3): δ: 8.40 (br, 1H, CONHPh), 7.43 (d, 2H, J7.7 Hz, 2Ha), 7.28 (d, 2H, J=7.7 Hz, Hb), 7.20 (m, 5H, 5xHd), 7.02 (t, 1H, J=7.4 Hz, He), 5.35 (d, 1H, J=7.8 Hz, CHNHBoc), 5.04 (d, 2H, J=2.6 Hz, BnOCH2), 4.26 (sa, 1H, CH2CHNHBoc), 2.60-2.52 (mc, 1H, 1xOCOCH2CH2), 2.46-2.38 (mc, 1H, 1xOCOCH2CH2), 2.21-2.12 (mc, 1H, 1xOCOCH2CH2), 1.99-1.90 (mc, 1H, 1x OCOCH2CH2), 1.40 (s, 9H, NHCO2C(CH3)3) ppm.MS: Positive mode [M+Na]+=435.MS: Negative mode [M+2 H2O-H]-=447.CAS nr: [126349-57-3]
94%		Example 1; Preparation of intermediate [6a]: Benzyl 4-(tert-butoxycarbonyl-amino)-5-oxo-5-(phenylamino) pentanoate To a stirred solution of Boc-L-glutamic acid 5-benzyl ester [4a1 (41 g, 122 mmol) in anhydrous CH2Cl2 (45 ml) at 0 C., was added during 15 minutes a solution of DCC (30.1 g, 146 mmol) in anhydrous CH2Cl2 (45 ml). The resulting white solid was sonicated. After that, anhydrous aniline was added dropwise to the reaction mixture over 10 minutes at 0 C. (11.1 ml, 122 mmol). The mixture was stirred at room temperature for 40 minutes and filtered through Celite to remove insoluble material. The resulting liquid was evaporated to dryness and chromatographically purified, yielding the desired product (47.2 g, 94%).1H-NMR (400 MHz, CDCl3): δ: 8.40 (br, 1H, CONHPh), 7.43 (d, 2H, J=7.7 Hz, 2Ha), 7.28 (d, 2H, J=7.7 Hz, Hb), 7.20 (m, 5H, 5× Hd), 7.02 (t, 1H, J=7.4 Hz, HO, 5.35 (d, 1H, J=7.8 Hz, CHNHBoc), 5.04 (d, 2H, J=2.6 Hz, BnOCH2), 4.26 (sa, 1H, CH2CHNHBoc), 2.60-2.52 (mc, 1H, 1× OCOCH2CH2), 2.46-2.38 (mc, 1H, 1× OCOCH2CH2), 2.21-2.12 (mc, 1H, 1× OCOCH2CH2), 1.99-1.90 (mc, 1H, 1× OCOCH2CH2), 1.40 (s, 9H, NHCO2C(CH3)3) ppm.MS: Positive mode [M+Na]+=435.MS: Negative mode [M +2 H2O-H]-=447.CAS nr: [126349-57-3]
94%	With dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20℃; for 0.833333h;	To a stirred solution of Boc-L-glutamic acid 5-benzyl ester [4a] (41 g, 122 mmol) in anhydrous CH2Cl2 (45 ml) at 0 C., was added during 15 minutes a solution of DCC (30.1 g, 146 mmol) in anhydrous CH2Cl2 (45 ml). The resulting white solid was sonicated. After that, anhydrous aniline was added dropwise to the reaction mixture over 10 minutes at 0 C. (11.1 ml, 122 mmol). The mixture was stirred at room temperature for 40 minutes and filtered through Celite to remove insoluble material. The resulting liquid was evaporated to dryness and chromatographically purified, yielding the desired product (47.2 g, 94%).1H-NMR (400 MHz, CDCl3): δ: 8.40 (br, 1H, CONHPh), 7.43 (d, 2H, J=7.7 Hz, 2Ha), 7.28 (d, 2H, J=7.7 Hz, Hb), 7.20 (m, 5H, 5×Hd), 7.02 (t, 1H, J=7.4 Hz, Hc), 5.35 (d, 1H, J=7.8 Hz, CHNHBoc), 5.04 (d, 2H, J=2.6 Hz, BnOCH2), 4.26 (sa, 1H, CH2CHNHBoc), 2.60-2.52 (mc, 1H, 1×OCOCH2CH2), 2.46-2.38 (mc, 1H, 1×OCOCH2CH2), 2.21-2.12 (mc, 1H, 1×OCOCH2CH2), 1.99-1.90 (mc, 1H, 1×OCOCH2CH2), 1.40 (s, 9H, NHCO2C(CH3)3) ppm.MS: Positive mode [M+Na]+=435.MS: Negative mode [M+2H2O-H]-=447.CAS nr: [126349-57-3].

References: [1]Patent: WO2010/150205,2010,A1 .Location in patent: Page/Page column 23-24.
[2]Patent: EP2450349,2012,A1 .Location in patent: Page/Page column 16.
[3]Patent: EP2447249,2012,A1 .Location in patent: Page/Page column 16.
[4]Patent: US2012/129888,2012,A1 .Location in patent: Page/Page column 15.
[5]Patent: US2012/122950,2012,A1 .Location in patent: Page/Page column 11.
[6]Patent: US2012/142930,2012,A1 .Location in patent: Page/Page column 14.

27
[ 117997-81-6 ]
[ 75-65-0 ]
[ 1310037-42-3 ]

Yield	Reaction Conditions	Operation in experiment
69.5%	With dicyclohexyl-carbodiimide;dmap; In dichloromethane; at 20℃; for 1h;	1,1-Dioxo-[1,2]thiazinane-3-carboxylic acid tert-butyl ester; This compound was prepared with a modified method described in the Journal of Medicinal Chemistry 2004, 47, 2981-2983. 2-tert-Butoxycarbonylamino-pentanedioic acid 5-benzyl ester (10 g, 29.6 mmol) was suspended in 80 ml of methylene chloride, 2-methyl-propan-2-ol (6.6 g, 88.9 mmol) was added and the reaction was cooled on ice-water bath. Dicyclohexylcarbodiimide (7.2 g, 34.4 mmol) was added slowly and followed by 4-dimethylaminopyridine (362 mg, 3.0 mmol). The reaction was stirred at room temperature for 1 hour. White solid was filtered and the filter cake was washed with methylene chloride. The filtrate was concentrated and the residue was treated with ether. After the solid was filtered off, the ether solution was washed with 0.5N HCl solution, brine and concentrated. The crude product was purified by using an ISCO (200 g) column chromatography, eluting with 5-20% ethyl acetate in hexanes to obtain 2-tert-butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-tert-butyl ester as a white solid. (8.1 g, 69.5%). LC-MS (ES) calculated for C21H31NO6, 393.5; found m/z 394.2 [M+H]+.

References: [1]Patent: US2011/136792,2011,A1 .Location in patent: Page/Page column 22.

28
[ 117997-81-6 ]
5-(tert-butoxy)-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid [ No CAS ]

References: [1]Patent: US2011/136792,2011,A1 .

29
[ 117997-81-6 ]
[ 1310037-46-7 ]

References: [1]Patent: US2011/136792,2011,A1 .

30
[ 117997-81-6 ]
[ 1310037-39-8 ]

References: [1]Patent: US2011/136792,2011,A1 .

31
[ 117997-81-6 ]
[ 1310037-48-9 ]

References: [1]Patent: US2011/136792,2011,A1 .

32
[ 117997-81-6 ]
[ 1310038-98-2 ]
[ 1310039-04-3 ]

References: [1]Patent: US2011/136792,2011,A1 .

33
[ 117997-81-6 ]
[ 1310039-00-9 ]

References: [1]Patent: US2011/136792,2011,A1 .

34
[ 117997-81-6 ]
[ 1310039-02-1 ]

References: [1]Patent: US2011/136792,2011,A1 .

35
[ 117997-81-6 ]
[ 1310039-06-5 ]
[ 1310039-12-3 ]

References: [1]Patent: US2011/136792,2011,A1 .

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Technical Information

• Acyl Group Substitution • Bouveault-Blanc Reduction • Catalytic Hydrogenation • Complex Metal Hydride Reductions • Ester Cleavage • Reactions of Benzene and Substituted Benzenes • Reactions with Organometallic Reagents • Specialized Acylation Reagents-Carbodiimides and Related Reagents

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P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 117997-81-6

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CAS No.: 117997-81-6

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[ 117997-81-6 ] Synthesis Path-Downstream 1~35

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