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Structure of 1175835-99-0

Chemical Structure| 1175835-99-0

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Product Details of [ 1175835-99-0 ]

CAS No. :1175835-99-0
Formula : C12H23NO3
M.W : 229.32
SMILES Code : O=C(N1CC(OCCC)CC1)OC(C)(C)C
MDL No. :MFCD08533291
InChI Key :ANTQYKULVIZWAS-UHFFFAOYSA-N
Pubchem ID :53413842

Safety of [ 1175835-99-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1175835-99-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1175835-99-0 ]

[ 1175835-99-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1175835-99-0 ]
  • [ 76-05-1 ]
  • [ 845543-54-6 ]
YieldReaction ConditionsOperation in experiment
100% In dichloromethane; at 20.0℃; for 2.0h; Preparation 9 CSOH-H20 (1. 2 equiv) and 4 A molecular sieves (70 mg/mmol substrate) were added sequentially to a DMF solution of 3-(R)-HYDROXY-1-BOC-PYRROLIDINE at RT. After 10 min, allyl bromide (2.0 equiv) was added and stirring continued for 18 h. The reaction was diluted with EtOAc, filtered, and acidified with 1 M HCI. The organic layer was washed with SAT D aq NAHCOS (2x) and sat'd NaC . (1x), then dried (MgS04) and concentrated. The residue was subjected to column chromatography (SiOz, 2% to 4% i-PrOH/hexanes) to give the alkylated intermediate. Pd (OH) 2 WAS added to a solution of this intermediate in MEOH, and the suspension was stirred under H2 FOR 18 h. The catalyst was removed by filtration and the filtrate was concentrated. The residue was treated with 20% TFA/CH2CI2 AT RT for 2h, then evaporated in vacuo to give the product as a salt (100%).
  • 2
  • [ 1478194-96-5 ]
  • [ 1175835-99-0 ]
YieldReaction ConditionsOperation in experiment
With hydrogen;palladium dihydroxide; In methanol; for 18.0h; Preparation 9 CSOH-H20 (1. 2 equiv) and 4 A molecular sieves (70 mg/mmol substrate) were added sequentially to a DMF solution of 3-(R)-HYDROXY-1-BOC-PYRROLIDINE at RT. After 10 min, allyl bromide (2.0 equiv) was added and stirring continued for 18 h. The reaction was diluted with EtOAc, filtered, and acidified with 1 M HCI. The organic layer was washed with SAT D aq NAHCOS (2x) and sat'd NaC . (1x), then dried (MgS04) and concentrated. The residue was subjected to column chromatography (SiOz, 2% to 4% i-PrOH/hexanes) to give the alkylated intermediate. Pd (OH) 2 WAS added to a solution of this intermediate in MEOH, and the suspension was stirred under H2 FOR 18 h. The catalyst was removed by filtration and the filtrate was concentrated. The residue was treated with 20% TFA/CH2CI2 AT RT for 2h, then evaporated in vacuo to give the product as a salt (100%).
 

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