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Chemical Structure| 116261-43-9 Chemical Structure| 116261-43-9

Structure of 116261-43-9

Chemical Structure| 116261-43-9

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Product Details of [ 116261-43-9 ]

CAS No. :116261-43-9
Formula : C13H17NO2
M.W : 219.28
SMILES Code : O=C([C@H]1NCCCC1)OCC2=CC=CC=C2
MDL No. :MFCD11975823

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Application In Synthesis of [ 116261-43-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 116261-43-9 ]

[ 116261-43-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 214147-60-1 ]
  • [ 116261-43-9 ]
  • [ 256527-06-7 ]
YieldReaction ConditionsOperation in experiment
Preparation 47 tert-Butyl 2-[(2S)-2-[(benzyloxy)carbonyl]-1-piperidinyl]-1H-1,3-benzimidazole-1-carboxylate The title compound was prepared by a similar method to Preparation 2 from tert-butyl 2-chloro-1H-i1,3-benzimidazole-1-carboxylate [see Preparation 46] and benzyl (2S)-2-piperidinecarboxylate [see J.A.C.S. (1 996), 118(7), 1629-1644]. The crude product was purified by column chromatography on silica gel eluding with a solvent gradient of 90:10 changing to 80:20, by volume, hexane:ethyl acetate, in 5% increments to afford tert-butyl 2-[(2S)-2-[(benzyloxy)carbonyl]-1-piperidinyl]-1H-1,3-benzimidazole-1-carboxylate as an oil. 1H-NMR (CDCl3) delta: 7.65 (1H, d), 7.45 (1H, d), 7.40 (2H, s), 7.25 (5H, m), 5.20 (2H, s), 4.70 (1H, m), 4.65 (1H, m), 3.60 (1H, m), 2.20 (1H, m), 2.05 (1H, m), 1.80-1.50 (13H, m). MS: 436 (MH+).
 

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