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Chemical Structure| 1150560-54-5 Chemical Structure| 1150560-54-5

Structure of 1150560-54-5

Chemical Structure| 1150560-54-5

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Product Details of [ 1150560-54-5 ]

CAS No. :1150560-54-5
Formula : C13H9F4IN2O2
M.W : 428.12
SMILES Code : O=C1NC(C(I)=C(C)N1CC2=C(C(F)(F)F)C=CC=C2F)=O
MDL No. :MFCD19441362
InChI Key :TZBUKGISILNJCR-UHFFFAOYSA-N
Pubchem ID :42606277

Safety of [ 1150560-54-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 1150560-54-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1150560-54-5 ]

[ 1150560-54-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1151564-03-2 ]
  • [ 1150560-54-5 ]
  • [ 1150560-56-7 ]
YieldReaction ConditionsOperation in experiment
70% Compound Ib (80 g, 0.19 mol), 7a (60.22 g, 0.22 mol), HP(^-Bu)3BF4 (13.01 g, 44.85 mmol), and Pd2(dba)3 (13.69 g, 14.95 mmol) were charged to the reaction vessel and purged with an inert atmosphere. Degassed THF (560 mL) was added followed by NaOH (31.45 g, 0.56 mol) in degassed water (128.8 mL) and the reaction warmed to 45 0C. After 2 hours acetic acid (56 mL) was added and stirred for 15 minutes. After settling, the layers were separated and the organic layer was filtered through celite, rinsing with hot THF (2 x 160 mL). The filtrate was concentrated in vacuo to a slurry, to which was added //-acetyl cysteine (15.84 g) as a solution in water (160 mL) and ethanol (640 mL) and stirred for 2 hours at 75 0C under an inert atmosphere. The slurry was cooled to RT, and the solids filtered off, washed with ethanohwater (8:2, 2 x 160 mL) to give 5-(2-chloro-3-methoxy-phenyl)-l-(2-fluoro-6-methyl-benzyl)-6-methyl-lH- pyrimidine-2,4-dione 7b as a white solid (58.6 g, 0.13 mol, 70 %).
 

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Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Chan-Lam Coupling Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

Categories

Related Functional Groups of
[ 1150560-54-5 ]

Fluorinated Building Blocks

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Aryls

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Amides

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Trifluoromethyls

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Related Parent Nucleus of
[ 1150560-54-5 ]

Pyrimidines

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