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Chemical Structure| 113964-33-3 Chemical Structure| 113964-33-3

Structure of 113964-33-3

Chemical Structure| 113964-33-3

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Product Details of [ 113964-33-3 ]

CAS No. :113964-33-3
Formula : C9H17ClSi
M.W : 188.77
SMILES Code : C[Si](C#CCCCCCl)(C)C
MDL No. :MFCD20621621

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Application In Synthesis of [ 113964-33-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 113964-33-3 ]

[ 113964-33-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 113964-33-3 ]
  • [ 183288-46-2 ]
  • [ 1187322-52-6 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In acetonitrile; for 72h;Heating; 6.6 g of (6-chloro-hex-1-ynyl)-trimethyl-silane, 11 g 5-piperazin-1-yl- benzofuran-2-carboxylic acid amide (Reitz et al., J. Med. Chem. 2005, 38:4211-22), and 8.3 ml_ triethyl-amine were dissolved in 100 mL acetonitrile and heated for 72 h. After cooling to RT the reaction mixture was poured on 10O mL water and 100 mL ethyl acetate. After the usual extraction and purification procedure 3.9 g colorless crystals 5-[4-(6-trimethylsilanyl-hex-5- ynyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide were obtained. HPLC: Chromolite Performance RP18-e 100-4,6 mmGradient: ACN/H2O witht 0,05% formic acid Method: Chromolith/Chromolith (extended) flow: 3mL/minRetention (Rt): 2.96 min [M+H]+: 398
 

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