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Chemical Structure| 1135299-23-8 Chemical Structure| 1135299-23-8

Structure of 1135299-23-8

Chemical Structure| 1135299-23-8

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Product Details of [ 1135299-23-8 ]

CAS No. :1135299-23-8
Formula : C9H7ClN2O2S
M.W : 242.68
SMILES Code : O=C(C1=C2C(C=CS2)=NC(Cl)=N1)OCC
MDL No. :MFCD17214222
InChI Key :CBZDCLKMFFKYCC-UHFFFAOYSA-N
Pubchem ID :59590526

Safety of [ 1135299-23-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 1135299-23-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1135299-23-8 ]

[ 1135299-23-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1135299-23-8 ]
  • [ 60289-67-0 ]
  • N-(1-(pyridin-3-yl)propyl)-2-((1-(pyridin-3-yl)propyl)amino)thieno[3,2-d]pyrimidine-4-carboxamide [ No CAS ]
  • 2-chloro-N-(1-(pyridin-3-yl)propyl)thieno[3,2-d]pyrimidine-4-carboxamide [ No CAS ]
  • ethyl 2-((1-(pyridin-3-yl)propyl)amino)thieno[3,2-d]pyrimidine-4-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
6%; 39%; 28% With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 130.0℃; for 3.0h; General procedure: To a solution of ethyl 2- chlorothieno[3,2-(/Jpyrimidine-4-carboxylate (100 mg, 0.41 mmol) and DIEA (0.22 mL, 1.23 mmol) in NMP (3 mL) was added (6-methoxypyridin-3-yl)methanamine hydrochloride (commercially obtained from PharmaBlock, Sunnyvale, CA) (97 mg, 0.89 mmol). The reaction mixture was stirred at 130 C for 3 h. The reaction mixture was cooled to room temperature, diluted with ethyl acetate and washed with 25% aqueous NaCl solution, then with brine three times and dried. The solvent was evaporated and the residue was purified by flash chromatography (24g, HP silica, Teledyne Isco) eluting with 2% to 100% solvent A (DCM/MeOH/NH4OH, 100/10/1) in DCM to provide 2-chloro-N-((6-methoxypyridin-3- yl)methyl)thieno[3,2-
 

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[ 1135299-23-8 ]

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