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Chemical Structure| 1126-76-7 Chemical Structure| 1126-76-7

Structure of 1126-76-7

Chemical Structure| 1126-76-7

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Product Details of [ 1126-76-7 ]

CAS No. :1126-76-7
Formula : C10H12O
M.W : 148.20
SMILES Code : C1(CCC2=CC=CC=C2)OC1
MDL No. :MFCD01657147

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Application In Synthesis of [ 1126-76-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1126-76-7 ]

[ 1126-76-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1126-76-7 ]
  • [ 926-39-6 ]
  • 2-(2-hydroxy-4-phenylbutyl)aminoethyl hydrogen sulphate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; In methanol; EXAMPLE 13 A mixture of 1,2-epoxy-4-phenylbutane (1.48 g.) and 2-aminoethyl hydrogen sulphate (7.05 g.) in methanol (7.5 ml.) and sodium hydroxide solution (18N, 2.8 ml.) is stirred at ambient temperature for 2 hours. The 2-(2-hydroxy-4-phenylbutyl)aminoethyl hydrogen sulphate formed as intermediate is not isolated but is cyclised in situ as follows:
  • 2
  • [ 1126-76-7 ]
  • [ 926-39-6 ]
  • [ 58039-64-8 ]
YieldReaction ConditionsOperation in experiment
Step B 2(RS)-(2-Phenylethyl)morpholine The title compound was obtained (2.55 g, 38percent) from (+-)-(3,4-epoxybutyl)-benzene (5.15 g, 0.0348 mol) and 2-aminoethyl hydrogen sulphate (20.63 g, 0.146 mol) as described in Example 2, Step A MS, CI+, m/z=192 for (M+H)+. 1 H NMR (360 MHz, CDCl3) delta1.63-1.85 (2H, m), 2.53-2.91 (6H, m), 3.38-3.42 (1H, m), 3.58 (1H, ddd, J1 =3, J2 =J3 =11 Hz), 3.88 (1H, dd, J1 =2, J2 =11 Hz), 7.15-7.29 (5H, m).
 

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