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Chemical Structure| 1123241-94-0 Chemical Structure| 1123241-94-0

Structure of 1123241-94-0

Chemical Structure| 1123241-94-0

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Product Details of [ 1123241-94-0 ]

CAS No. :1123241-94-0
Formula : C15H23ClN4O2
M.W : 326.82
SMILES Code : O=C(OC(C)(C)C)NCC1CCN(C2=NC(Cl)=NC=C2)CC1

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Application In Synthesis of [ 1123241-94-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1123241-94-0 ]

[ 1123241-94-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 476620-22-1 ]
  • [ 1123241-94-0 ]
  • [ 1428581-93-4 ]
YieldReaction ConditionsOperation in experiment
6.05 g With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate; In 1,4-dioxane; water; at 85℃; for 2.0h;Inert atmosphere; The product obtained in the previous step (5.92 g, 18.1 mmol), <strong>[476620-22-1]3-pyrazolephenylboronic acid</strong> (3.41 g, 18.1 mmol), potassium carbonate (7.51 g, 54.3 mmol) and Pd(dppf)2CI2 were dissolved in dioxane:water (150 ml, 9:1 ). After purging with N2 for 15 minutes, the reaction mixture was heated to 85 C for 2 hours and then cooled to ambient temperature. The solvents were removed under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic phase was separated and concentrated under reduced pressure giving a dark solid (9.59 g). The crude solid was purified using normal phase chromatography eluting with /'so-hexane and increasing amounts of ethyl acetate to give tert-butyl (1 -(2-(3-(1 H-pyrazol- 1 -yl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methylcarbamate as a pink solid (6.05 g).
 

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