1115-74-8|D-Valyl-D-alanine| Ambeed

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Quality Control of [ 1115-74-8 ] Purity: 95% SDS Specification

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Product Details of [ 1115-74-8 ]

CAS No. :	1115-74-8
Formula :	C₈H₁₆N₂O₃
M.W :	188.22
SMILES Code :	C[C@H](C(O)=O)NC([C@@H](C(C)C)N)=O

Safety of [ 1115-74-8 ]

Application In Synthesis of [ 1115-74-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1115-74-8 ]

[ 1115-74-8 ] Synthesis Path-Downstream 1~35

1
[ 1478-88-2 ]
[ 1115-74-8 ]

References: [1]Chemische Berichte,1959,vol. 92,p. 517,527.

2
[ 6491-36-7 ]
[ 1115-74-8 ]

References: [1]Fermentforschung,1930,vol. 11,p. 274.

3
[ 17445-33-9 ]
[ 1115-74-8 ]

Yield	Reaction Conditions	Operation in experiment
1.2%	With palladium on activated charcoal; hydrogen; In methanol; for 16h;	To a solution of ((benzyloxy)carbonyl)-L-valyl-L-alanine (1 g, 3.10 mmol) in methanol (20 mL) was added Pd-C (0.330 g, 0.310 mmol) under N2. The reaction mixture was stirred under hydrogen pressure for 16 h. The reaction mixture was filtered through a celite bed. The bed was washed with methanol (40 mL). The clear filtrate was collected and evaporated to dryness to yield L-valyl-L-alanine (3.5 mg, 1.2 % yield) as a white solid. LCMS: m/z = 189.2 (M+H); rt 0.17 min; Column-Kinetex XB-C18 (75X3 mm-2.6 ^m), Mobile phase A: 10 mM ammonium formate in water:acetonitrile (98:2), Mobile phase B: 10 mM ammonium formate in water: acetonitrile (2:98).

References: [1]Patent: WO2020/6018,2020,A1 .Location in patent: Page/Page column 263.
[2]Justus Liebigs Annalen der Chemie,1963,vol. 661,p. 193 - 201.

4
[ 1115-74-8 ]
[ 917-95-3 ]
C₁₁H₂₄N₃O₂*H⁽¹⁺⁾ [ No CAS ]

References: [1]Journal of Physical Chemistry,1981,vol. 85,p. 2398 - 2403.

5
[ 47094-07-5 ]
[ 1115-74-8 ]

References: [1]Bulletin of the Chemical Society of Japan,1981,vol. 54,p. 2705 - 2707.

Yield	Reaction Conditions	Operation in experiment
		In one embodiment, the group -X1-X2- in dipeptide, -NH-X1-X2-CO-, is selected from: -Phe-Lys-, -Val-Ala-, -Val-Lys-, -Ala-Lys-, -Val-Cit-, -Phe-Cit-, -Leu-Cit-, -Ile-Cit-, -Phe-Arg-, ...
		claim 3 , wherein L1 comprises a dipeptide and the group -X1-X2- in dipeptide, -NH-X1-X2-CO-, is selected from: -Phe-Lys-, -Val-Ala-, -Val-Lys-, -Ala-Lys-, -Val-Cit-, -Phe-Cit-, -Leu-Cit-, -Ile-Cit-, -Phe-Arg-, ...

7
[ 1115-74-8 ]
[ 110661-49-9 ]
sodium N-undecylenyl-L-valyl-L-alanine [ No CAS ]

References: [1]Analytical Chemistry,2000,vol. 72,p. 1740 - 1748.

8
[ 118234-89-2 ]
[ 1115-74-8 ]

References: [1]Chemical Communications,2005,p. 4946 - 4948.

9
[ 41445-88-9 ]
(S)-Ala ester salt [ No CAS ]
[ 1115-74-8 ]

References: [1]Chemistry - A European Journal,2006,vol. 12,p. 5383 - 5397.

10
[ 1149-26-4 ]
[ 1115-74-8 ]

References: [1]Chemistry - A European Journal,2006,vol. 12,p. 5383 - 5397.
[2]Organic and Biomolecular Chemistry,2006,vol. 4,p. 38 - 40.
[3]Chemical Communications,2005,p. 4946 - 4948.
[4]Justus Liebigs Annalen der Chemie,1963,vol. 661,p. 193 - 201.

11
[ 41445-88-9 ]
H₂N-L-phe-CO₂Bn salt [ No CAS ]
[ 1115-74-8 ]

References: [1]Organic and Biomolecular Chemistry,2006,vol. 4,p. 38 - 40.
[2]Chemical Communications,2005,p. 4946 - 4948.

12
[ 24601-74-9 ]
[ 1115-74-8 ]

References: [1]Bulletin of the Chemical Society of Japan,1981,vol. 54,p. 2705 - 2707.

13
[ 349-00-8 ]
[ 1115-74-8 ]

References: [1]Chemische Berichte,1959,vol. 92,p. 517,527.

14
[ 55739-16-7 ]
[ 1115-74-8 ]

References: [1]Justus Liebigs Annalen der Chemie,1963,vol. 661,p. 193 - 201.

15
scandium(III) nitrate [ No CAS ]
[ 1115-74-8 ]
Sc(H₂O)4OH⁽²⁺⁾*NH₂CHCO(CH(CH₃)2)NHCH(CH₃)COO^(1-)={Sc(H₂O)4(NH₂CHCO(CH(CH₃)2)NHCH(CH₃)COO)OH}⁽¹⁺⁾ [ No CAS ]

References: [1]Inorganica Chimica Acta,1989,vol. 158,p. 265 - 271.

16
[ 1115-74-8 ]
6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-((S)-7-methoxy-8-(3-(((S)-7-methoxy-5-oxo-2-((E)-styryl)-5,11a-dihydro-pyrrolo[2,1-c][1,4]benzodiazepin-8-yl)oxy)propoxy)-5-oxo-5,11a-dihydro-pyrrolo[2,1-c][1,4]benzodiazepin-2-yl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide [ No CAS ]

References: [1]Patent: WO2011/130616,2011,A1 .

17
[ 1115-74-8 ]
[ 1342211-57-7 ]

References: [1]Patent: WO2011/130616,2011,A1 .

18
[ 55750-63-5 ]
[ 1115-74-8 ]
[ 1342211-31-7 ]

Yield	Reaction Conditions	Operation in experiment
97%	With triethylamine; In N,N-dimethyl-formamide; at 20℃;	150 mg (0.797 mmol) of <strong>[1115-74-8]L-valyl-L-alanine</strong> and 246 mg (0.797 mmol) of 1-{6-[(2,5-dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-1H-pyrrole-2,5-dione were dissolved in 4.0 ml of dimethylformamide, and 0.220 ml (1.6 mmol) of triethylamine was added. The reaction mixture was stirred at RT overnight. The reaction mixture was purified directly by preparative RP-HPLC (column: Reprosil 250*30; 10mu, flow rate; 50 ml/min, MeCN/water). The solvents were evaporated under reduced pressure and the residue was dried under high vacuum. This gave 302 mg (97% of theory) of N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl) hexanoyl]-<strong>[1115-74-8]L-valyl-L-alanine</strong>. LC-MS (Method 12): Rt=1.02 min; MS (ESIpos): m/z=382 (M+H)+. 1H-NMR (400 MHz, DMSO-d6): delta [ppm]=0.82 (dd, 6H), 1.17 (m, 2H), 1.27 (d, 3H), 1.48 (m, 4H), 1.94 (m, 1H), 2.13 (m, 2H), 3.38 (t, 2H), 4.17 (m, 2H), 7.00 (s, 2H), 7.75 (d, 1H), 8.19 (d, 1H).
70%	With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃;Inert atmosphere;	Maeilimidocaproy. N-hydroxysuccinimide (1.619 g, 5.25 mmo., 105 eq.) and H-Val-Aia-OH (0,941 g, 5 mmol, 1 eq.) were placed in a 25 ml recovery fiask with a stir bar and the flask was flushed with nitrogen, DMF (4,7 mL) was added and the resulting white siurry was stirred. DIPEA (0.87 mL, 5 mmol, 1 eq) was added and the mixture was allowed to stir at room temperature overnight. The mixture was coo.ed in an ice/water bath and 2M HCI (3 mL, 6 mmol) was added dropwise. The viscous mixture was transferred to a separator/ funnel and the reaction vessel rinsed with sat. NaCl (7 mL), EtOAc (10 mL), sat NaCl {10 mL) and EtOAc (5 mL). After separation of the aqueous phase, it was extracted with additionai EtOAc {2 x 15 mL). The combined organic extracts were washed with sat NaCi {4 x 15 mL), until the washings were pH ~3,5. The organic extracts were dried over Na2S04, filtered and concentrated under reduced pressure to give crude 5 as a white solid (2,1 2 g, 114% crude yield). Crude 5 was suspended in warm CHjCIa {35 mL) and filtered to remov a fine white solid. The solids wer rinsed with additional CHjCi2 (3 mL). Toiuene {5mL) was added and the mixture was cooled in an ice/water bath, which resulted in a thick siurry. The solids were collected by filtration, washed with a cold mixture of CHjC (12 mL) and toluene (2 mL) and dried by puiilng air through the sample overnight to give 5 as a White solid (1 ,327 g, 70% yield). TLC: Rf = 0.26, 10% MeOH in CH2CI2. 1 H NMR (CDCI3)(ppm) 0.95 {d, J - 17 Hz, 3H), 0.98 (d, J - 17 Hz, 3H), 1.30 (m, 2H), 1.40 (d, J = 17 Hz, 3H), 1.61 (m, 4H), 2.06 (m, 1 H), 2.25 (dt, J = 4, 19 Hz, 2H). 3.35 (s, 1 H), 3.49 (t, J - 17 Hz,2H), 4.20 (d, J = 18 Hz, 1 H), 4.38 (m, 1 H), 6.80 {s, 2H). Analytical HPLC (0.1% formic acid): tR 9.05 min. LC-MS: tR 11.17 min, m/z (ES+) found 381.9 (M+H)+, m/z (ES-) found 379.9 (M-H)-.
52%	In N,N-dimethyl-formamide; at 20℃; for 48h;	(a) (S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3- methylbutanamido)propanoic acid (23)A suspension of dipeptide (22) (0.1 g, 0.54 mmol, 1 eq.) and 6-maleimidohexanoic acid succinimide ester (0.165 g, 0.54 mmol, 1 eq.) in anhydrous DMF (5 mL) was stirred at room temperature for 24 hours at which time LCMS indicated 50% conversion to a new product. The reaction mixture was diluted with anhydrous DMF (5 mL) and the reaction was allowed to continue for a further 24 hours. The solvent was evaporated under reduced pressure to give a colourless residue. Diethyl ether (60 mL) was added and the mixture was sonicated for 5 min, the ether was decanted and the process was repeated (x 2). The final ethereal portion was filtered to isolate the product (23) as a white powder which was dried under vacuum (0.105 g, 52%). Analytical Data: RT 2.28 min; MS (ES+) m/z (relative intensity) 382 ([M + H]+ , 90), MS (ES") m/z (relative intensity) 380 ([M - H])-, 100).

With triethylamine;

150 mg (0.797 mmol) of <strong>[1115-74-8]L-valyl-L-alanine</strong> and 246 mg (0.797 mmol) of 1-{6-[(2,5-dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-1H-pyrrole-2,5-dione were dissolved in 4.0 ml of dimethylformamide, and 0.220 ml (1.6 mmol) of triethylamine were added. The reaction mixture was stirred at RT overnight. The reaction mixture was purified directly by preparative RP-HPLC (column: Reprosil 250*30; 10mu, flow rate: 50 ml/min, MeCN/water). The solvents were evaporated under reduced pressure and the residue was dried under high vacuum. This gave 302 mg (97% of theory) of N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-<strong>[1115-74-8]L-valyl-L-alanine</strong>. LC-MS (Method 12): Rt=1.02 min; MS (ESIpos): m/z=382 (M+H)+. 1H-NMR (400 MHz, DMSO-d6): delta [ppm]=0.82 (dd, 6H), 1.17 (m, 2H), 1.27 (d, 3H), 1.48 (m, 4H), 1.94 (m, 1H), 2.13 (m, 2H), 3.38 (t, 2H), 4.17 (m, 2H), 7.00 (s, 2H), 7.75 (d, 1H), 8.19 (d, 1H).

References: [1]Patent: US2019/77752,2019,A1 .Location in patent: Paragraph 2160-2163.
[2]Patent: WO2013/55993,2013,A1 .Location in patent: Page/Page column 93.
[3]Patent: WO2011/130616,2011,A1 .Location in patent: Page/Page column 86-87.
[4]Bioconjugate Chemistry,2013,vol. 24,p. 1256 - 1263.
[5]Patent: US2018/169256,2018,A1 .

19
[ 1115-74-8 ]
[ 154050-82-5 ]
[ 1357569-36-8 ]

References: [1]Structural Chemistry,2013,vol. 24,p. 1461 - 1471.
[2]Bioorganic Chemistry,2012,vol. 40,p. 19 - 29.

20
C₈H₁₅N₂O₃Pol [ No CAS ]
[ 1115-74-8 ]

References: [1]Bioorganic Chemistry,2012,vol. 40,p. 19 - 29.

21
[ 1115-74-8 ]
[ 28920-43-6 ]
[ 150114-97-9 ]

Yield	Reaction Conditions	Operation in experiment
97%	With sodium carbonate; In 1,4-dioxane; water; at 0℃; for 18h;	(a) (R)-2-((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbuta propanoic acid (20b) HO-Ala-Val-H 20a (350 mg, 1.86 mmol) and Na2C03 (493 mg, 4.65 mmol) were dissolved in distilled H20 (15 ml.) and the mixture was cooled to 0C before dioxane (15 ml.) was added (partial precipitation of the amino acid salt occurred). A solution of Fmoc-CI (504 mg, 1 .95 mmol) in dioxane (15 ml.) was added dropwise with vigorous stirring over 10 minutes. The resulting mixture was stirred at 0C for 2 hours before the ice bath was removed and stirring was maintained for 16 hours. The solvent was removed by rotary evaporation under reduced pressure and the residue dissolved in water (150 ml_). The pH was adjusted from 9 to 2 with 1 N HCI and the aqueous layer was subsequently extracted with EtOAc (3x100 ml_). The combined organics were washed with brine (100 ml_), dried with MgS04, filtered and the volatiles removed by rotary evaporation under reduced pressure to afford pure HO-Ala-Val- Fmoc 20b (746 mg, 97% yield). LC/MS 2.85 min (ES+) m/z (relative intensity) 410.60 ; 1H- NMR (400 MHz, CDCI3) delta 7.79 (d, J=7.77 Hz, 2H), 7.60(d, J=7.77 Hz, 2H), 7.43(d, J=7.5 Hz, 2H), 7.34 (d, J=7.5 Hz, 2H), 6.30 (bs, 1 H), 5.30 (bs, 1 H), 4.71-7.56 (m, 1 H), 4.54-4.36 (m, 2H), 4.08-3.91 (m, 1 H), 2.21-2.07 (m, 1 H), 1.50 (d, J=l A Hz, 3H), 1.06-0.90 (m, 6H).
97%	With sodium carbonate; In 1,4-dioxane; water; at 0℃; for 18h;	HO-Ala-Val-H 1 (350 mg, 1.86 mmol) and Na2C03 (493 mg, 4.65 mmol) were dissolved in distilled H20 (15 mL) and the mixture was cooled to 0C before dioxane (15 mL) was added (partial precipitation of the amino acid salt occurred). A solution of Fmoc-CI (504 mg, 1 .95 mmol) in dioxane (15 mL) was added dropwise with vigorous stirring over 10 minutes. The resulting mixture was stirred at 0C for 2 hours before the ice bath was removed and stirring was maintained for 16 hours. The solvent was removed by rotary evaporation under reduced pressure and the residue dissolved in water (150 mL). The pH was adjusted from 9 to 2 with 1 N HCI and the aqueous layer was subsequently extracted with EtOAc (3x100 mL). The combined organics were washed with brine (100 mL), dried with MgS04, filtered and the volatiles removed by rotary evaporation under reduced pressure to afford pure HO-Ala-Val- Fmoc 2 (746 mg, 97% yield). LC/MS 2.85 min (ES+) m/z (relative intensity) 410.60 ; 1H-NMR (400 MHz, CDCI3) delta 7.79 (d, J=7.77 Hz, 2H), 7.60(d, J=7.77 Hz, 2H), 7.43(d, J=7.5 Hz, 2H), 7.34 (d, J=7.5 Hz, 2H), 6.30 (bs, 1 H), 5.30 (bs, 1 H), 4.71 -7.56 (m, 1 H), 4.54-4.36 (m, 2H), 4.08-3.91 (m, 1 H), 2.21 -2.07 (m, 1 H), 1 .50 (d, J=7.1 Hz, 3H), 1 .06-0.90 (m, 6H).
97%	With sodium carbonate; In 1,4-dioxane; water; at 0℃; for 18h;	HO-Ala-Val-H 1 (350 mg, 1 .86 mmol) and Na2C03 (493 mg, 4.65 mmol) were dissolved in distilled H20 (15 ml.) and the mixture was cooled to 0C before dioxane (15 ml.) was added (partial precipitation of the amino acid salt occurred). A solution of Fmoc-CI (504 mg, 1.95 mmol) in dioxane (15 mL) was added dropwise with vigorous stirring over 10 minutes. The resulting mixture was stirred at 0C for 2 hours before the ice bath was removed and stirring was maintained for 16 hours. The solvent was removed by rotary evaporation under reduced pressure and the residue dissolved in water (150 mL). The pH was adjusted from 9 to 2 with 1 N HCI and the aqueous layer was subsequently extracted with EtOAc (3x100 mL). The combined organics were washed with brine (100 mL), dried with MgS04, filtered and the volatiles removed by rotary evaporation under reduced pressure to afford pure HO- Ala-Val-Fmoc 2 (746 mg, 97% yield). LC/MS 2.85 min (ES+) m/z (relative intensity) 410.60 ; 1H-NMR (400 MHz, CDCI3) delta 7.79 (d, J=7.77 Hz, 2H), 7.60(d, J=7.77 Hz, 2H), 7.43(d, J=7.5 Hz, 2H), 7.34 (d, J=7.5 Hz, 2H), 6.30 (bs, 1 H), 5.30 (bs, 1 H), 4.71-7.56 (m, 1 H), 4.54-4.36 (m, 2H), 4.08-3.91 (m, 1 H), 2.21-2.07 (m, 1 H), 1 .50 (d, J=1A Hz, 3H), 1.06-0.90 (m, 6H).

97%	With sodium carbonate; In 1,4-dioxane; water; at 0℃; for 18h;	HO-Ala-Val-H 20a (350 mg, 1.86 mmol) and Na2CO3 (493 mg, 4.65 mmol) were dissolved in distilled H20 (15 mL) and the mixture was cooled to 0C before dioxane (15mL) was added (partial precipitation of the amino acid salt occurred). A solution of FmocCl (504 mg, 1.95 mmol) in dioxane (15 mL) was added dropwise with vigorous stirring over 10 minutes. The resulting mixture was stirred at 0C for 2 hours before the ice bath was removed and stirring was maintained for 16 hours. The solvent was removed by rotary evaporation under reduced pressure and the residue dissolved in water (150 mL). The pHwas adjusted from 9 to 2 with iN HC1 and the aqueous layer was subsequently extracted with EtOAc (3x100 mL). The combined organics were washed with brine (100 mL), dried with MgSO4, filtered and the volatiles removed by rotary evaporation under reduced pressure to afford pure HO-Ala-Val-Fmoc 20b (746 mg, 97% yield). LC/MS 2.85 mm (ES+) rn/z (relative intensity) 410.60 ; ?H-NMR (400 MHz, CDC13) oe 7.79 (d, J7.77 Hz,2H), 7.60(d, J=7.77 Hz, 2H), 7.43(d, J=7.5 Hz, 2H), 7.34 (d, J=7.5 Hz, 2H), 6.30 (bs, 1H),5.30 (bs, 1H), 4.71-7.56 (m, 1H), 4.54-4.36 (m, 2H), 4.08-3.91 (m, 1H), 2.21-2.07 (m,1H), 1.50 (d,J=7.1 Hz, 3H), 1.06-0.90 (m, 6H).
97%	With sodium carbonate; In 1,4-dioxane; water; at 0℃; for 18.16h;	HO-Ala-Val-H 13(350 mg, 1.86 mmol) and Na2CO3 (493 mg, 4.65 mmol) were dissolved indistilled H20 (15 mL) and the mixture was cooled to 0C before dioxane (15 mL) was added(partial precipitation of the amino acid salt occurred). A solution of Fmoc-Cl (504 mg, 1 .95 mmol) in dioxane (15 mL) was added dropwise with vigorous stirring over 10 minutes. The resulting mixture was stirred at 0C for 2 hours before the ice bath was removed and stirring was maintained for 16 hours. The solvent was removed by rotary evaporation under reduced pressure and the residue dissolved in water (150 mL). The pH was adjusted from 9 to 2 with IN HCI and the aqueous layer was subsequently extracted with EtOAc (3x100 mL). Thecombined organics were washed with brine (100 mL), dried with MgSO4, filtered and the volatiles removed by rotary evaporation under reduced pressure to afford pure HO-Ala-ValFmoc 14 (746 mg, 97% yield). LC/MS 2.85 mm (ES+) m/z (relative intensity) 410.60 ; NMR (400 MHz, CDCI3) 5 7.79 (d, J7.77 Hz, 2H), 7.60(d, J7.77 Hz, 2H), 7.43(d, J7.5 Hz, 2H), 7.34 (d, J=7.5 Hz, 2H), 6.30 (bs, IH), 5.30 (bs, IH), 4.71-7.56 (m, IH), 4.54-4.36 (m,2H), 4.08-3.91 (m, IH), 2.21-2.07 (m, IH), 1.50 (d, J=7.1 Hz, 3H), 1.06-0.90 (m, 6H).
97%	With sodium carbonate; In 1,4-dioxane; water; at 0℃; for 18h;	HO-Ala-Val-H 13 (350 mg, 1 .86 mmol) and Na2C03 (493 mg, 4.65 mmol) were dissolved in distilled H20 (15 ml.) and the mixture was cooled to 0C before dioxane (15 ml.) was added (partial precipitation of the amino acid salt occurred). A solution of Fmoc-CI (504 mg, 1 .95 mmol) in dioxane (15 ml.) was added dropwise with vigorous stirring over 10 minutes. The resulting mixture was stirred at 0C for 2 hours before the ice bath was removed and stirring was maintained for 16 hours. The solvent was removed by rotary evaporation under reduced pressure and the residue dissolved in water (150 ml_). The pH was adjusted from 9 to 2 with 1 N HCI and the aqueous layer was subsequently extracted with EtOAc (3x100 ml_). The combined organics were washed with brine (100 ml_), dried with MgS04, filtered and the volatiles removed by rotary evaporation under reduced pressure to afford pure HO-Ala-Val- Fmoc 14 (746 mg, 97% yield). LC/MS 2.85 min (ES+) m/z (relative intensity) 410.60 ; 1 H- NMR (400 MHz, CDCI3) delta 7.79 (d, J=7.77 Hz, 2H), 7.60(d, J=7.77 Hz, 2H), 7.43(d, J=7.5 Hz, 2H), 7.34 (d, J=7.5 Hz, 2H), 6.30 (bs, 1 H), 5.30 (bs, 1 H), 4.71 -7.56 (m, 1 H), 4.54-4.36 (m, 2H), 4.08-3.91 (m, 1 H), 2.21 -2.07 (m, 1 H), 1 .50 (d, J=7.1 Hz, 3H), 1 .06-0.90 (m, 6H).
97%	With sodium carbonate; In 1,4-dioxane; water; at 0℃; for 18.16h;	HO-Ala-Val-H 13(350 mg, 1.86 mmol) and Na2CO3 (493 mg, 4.65 mmol) were dissolved indistilled H20 (15 mL) and the mixture was cooled to 0C before dioxane (15 mL) was added(partial precipitation of the amino acid salt occurred). A solution of Fmoc-Cl (504 mg, 1 .95 mmol) in dioxane (15 mL) was added dropwise with vigorous stirring over 10 minutes. The resulting mixture was stirred at 0C for 2 hours before the ice bath was removed and stirring was maintained for 16 hours. The solvent was removed by rotary evaporation under reduced pressure and the residue dissolved in water (150 mL). The pH was adjusted from 9 to 2 with IN HCI and the aqueous layer was subsequently extracted with EtOAc (3x100 mL). Thecombined organics were washed with brine (100 mL), dried with MgSO4, filtered and the volatiles removed by rotary evaporation under reduced pressure to afford pure HO-Ala-ValFmoc 14 (746 mg, 97% yield). LC/MS 2.85 mm (ES+) m/z (relative intensity) 410.60 ; NMR (400 MHz, CDCI3) 5 7.79 (d, J7.77 Hz, 2H), 7.60(d, J7.77 Hz, 2H), 7.43(d, J7.5 Hz, 2H), 7.34 (d, J=7.5 Hz, 2H), 6.30 (bs, IH), 5.30 (bs, IH), 4.71-7.56 (m, IH), 4.54-4.36 (m,2H), 4.08-3.91 (m, IH), 2.21-2.07 (m, IH), 1.50 (d, J=7.1 Hz, 3H), 1.06-0.90 (m, 6H).
97%	With sodium carbonate; In 1,4-dioxane; water; at 0℃; for 18.16h;	HO-Ala-Val-H 13(350 mg, 1.86 mmol) and Na2CO3 (493 mg, 4.65 mmol) were dissolved indistilled H20 (15 mL) and the mixture was cooled to 0C before dioxane (15 mL) was added(partial precipitation of the amino acid salt occurred). A solution of Fmoc-Cl (504 mg, 1 .95 mmol) in dioxane (15 mL) was added dropwise with vigorous stirring over 10 minutes. The resulting mixture was stirred at 0C for 2 hours before the ice bath was removed and stirring was maintained for 16 hours. The solvent was removed by rotary evaporation under reduced pressure and the residue dissolved in water (150 mL). The pH was adjusted from 9 to 2 with IN HCI and the aqueous layer was subsequently extracted with EtOAc (3x100 mL). Thecombined organics were washed with brine (100 mL), dried with MgSO4, filtered and the volatiles removed by rotary evaporation under reduced pressure to afford pure HO-Ala-ValFmoc 14 (746 mg, 97% yield). LC/MS 2.85 mm (ES+) m/z (relative intensity) 410.60 ; NMR (400 MHz, CDCI3) 5 7.79 (d, J7.77 Hz, 2H), 7.60(d, J7.77 Hz, 2H), 7.43(d, J7.5 Hz, 2H), 7.34 (d, J=7.5 Hz, 2H), 6.30 (bs, IH), 5.30 (bs, IH), 4.71-7.56 (m, IH), 4.54-4.36 (m,2H), 4.08-3.91 (m, IH), 2.21-2.07 (m, IH), 1.50 (d, J=7.1 Hz, 3H), 1.06-0.90 (m, 6H).
97%		HO-Ala-Val-H 20a (350 mg, 1.86 mmol) and Na2C03 (493 mg, 4.65 mmol) were dissolved in distilled H20 (15 niL) and the mixture was cooled to 0C before dioxane (15 mL) was added (partial precipitation of the amino acid salt occurred). A solution of Fmoc-Cl (504 mg, 1.95 mmol) in dioxane (15 mL) was added dropwise with vigorous stirring over 10 minutes. The resulting mixture was stirred at 0C for 2 hours before the ice bath was removed and stirring was maintained for 16 hours. The solvent was removed by rotary evaporation under reduced pressure and the residue dissolved in water (150 mL). The pH was adjusted from 9 to 2 with IN HC1 and the aqueous layer was subsequently extracted with EtOAc (3x100 mL). The combined organics were washed with brine (100 mL), dried with MgS04, filtered and the volatiles removed by rotary evaporation under reduced pressure to afford pure HO-Ala-Val-Fmoc 20b (746 mg, 97% yield). LC/MS 2.85 min (ES+) m/z (relative intensity) 410.60 ; 1H-NMR (400 MHz, CDC13) delta 7.79 (d, .7=7.77 Hz, 2H), 7.60(d, .7=7.77 Hz, 2H), 7.43(d, .7=7.5 Hz, 2H), 7.34 (d, .7=7.5 Hz, 2H), 6.30 (bs, IH), 5.30 (bs, IH), 4.71-7.56 (m, IH), 4.54-4.36 (m, 2H), 4.08-3.91 (m, IH), 2.21- 2.07 (m, IH), 1.50 (d, .7=7.1 Hz, 3H), 1.06-0.90 (m, 6H).
97%	With sodium carbonate; In 1,4-dioxane; water; at 0℃; for 2.16667h;	(a) (R)-2-((R)-2-((((9H-fluoren-9-yI)methoxy)carbonyl)amino)-3-methylbutanamido) propanoic acid (20b)HO-Ala-Val-H 20a (350 mg, 1.86 mmol) and Na2003 (493 mg, 4.65 mmol) were dissolved in distilled H20 (15 mL) and the mixture was cooled to 0C before dioxane (15 mL) was added (partial precipitation of the amino acid salt occurred). A solution of Fmoc-Cl (504 mg, 1.95 mmol) in dioxane (15 mL) was added dropwise with vigorous stirring over 10 minutes. The resulting mixture was stirred at 0C for 2 hours before the ice bath was removed and stirring was maintained for 16 hours. The solvent was removed by rotary evaporation under reduced pressure and the residue dissolved in water (150 mL). The pH was adjusted from 9 to 2 with iN HCI and the aqueous layer was subsequently extracted with EtOAc (3x100 mL). The combined organics were washed with brine (100 mL), dried with MgSO4, filtered and the volatiles removed by rotary evaporation under reduced pressure to afford pure HO-Ala-ValFmoc 20b (746 mg, 97% yield). LC/MS 2.85 mm (ES+) m/z (relative intensity) 410.60; NMR (400 MHz, CDCI3) O 7.79 (d, J=7.77 Hz, 2H), 7.60(d, J=7.77 Hz, 2H), 7.43(d, J=7.5 Hz, 2H), 7.34 (d, J=7.5 Hz, 2H), 6.30 (bs, 1H), 5.30 (bs, 1H), 4.71-7.56 (m, 1H), 4.54-4.36 (m, 2H), 4.08-3.91 (m, 1H), 2.21-2.07 (m, 1H), 1.50 (d, J=7.1 Hz, 3H), 1.06-0.90 (m, 6H).
94%	With sodium carbonate; In 1,4-dioxane; water; at 0 - 20℃; for 18h;	H-<strong>[1115-74-8]Val-Ala</strong>-OH 11 (1 .0g, 5.313 mmol, 1.0 eq.) and Na2C03 (1 .42 g, 13.282 mmol, 2.5 eq.) were solubilised in distilled H20 (40 mL) and the mixture was cooled to 0C before dioxane (40 mL) was added. Partial precipitation of the amino acid salt occurred. A solution of Fmoc-CI (1.44 g, 5.579 mmol, 1 .05 eq.) dissolved in dioxane (40 mL) was added dropwise with vigorous stirring over 10 minutes. The resulting mixture was stirred at 0C for 2 hours before the ice bath was removed and the stirring maintained for 16 hours. The solvent was evaporated under reduced pressure and the solid remaining dissolved in water (450 mL). The pH was adjusted to 2 with 1 N HCI (25 mL) and the aqueous layer was subsequently extracted with EtOAc (3 x 250 mL). The combined organics were washed with brine (100 mL), dried over MgS04, filtered and the volatiles removed under reduced pressure to afford pure HO-Ala-Val-Fmoc 12 as a white solid (2.06 g, 94%). LC/MS (2.758min (ES+)), m/z: 41 1 .0 [M+H]+. 1H NMR (400 MHz, DMSO-d6) delta 12.47 (br s, 1 H), 8.20 (d, 1 H, J = 6.7 Hz), 7.89 (d, 2H, J = 7.5 Hz), 7.75 (t, 2H, J = 6.8 Hz), 7.43 - 7.38 (m, 3H), 7.34 - 7.30 (m, 2H), 4.31 - 4.16 (m, 4H), 3.88 (dd, 1 H, J = 8.8, 7.2 Hz), 1 .98 (m, 1 H), 1 .26 (d, 3H, J = 7.3 Hz), 0.89 (d, 3H, J = 6.8 Hz), 0.86 (d, 3H, J = 6.8 Hz).
	With sodium carbonate; In 1,4-dioxane; water; at 0 - 20℃; for 18h;	To a solution of <strong>[1115-74-8]Val-Ala</strong>-OH (1 g, 5.31 mM) in water (40 ml) is added Na2C03(1.42 g, 13.28 mM) and cooled to 0C before dioxane (40 mL) is added. A solution of Fmoc-Cl (1.44 g, 5.58 mM) in dioxane (40 mL) is added dropwise over 10 min at 0C. The reaction mixture is stirred at 0C for 2h, then allowed to stir at RT for 16 h. Dioxane is removed under vacuum, the reaction mixture diluted with water (450 mL), pH is adjusted to 2 using IN HC1 and extracted with EtOAc (3 x 250 mL). The combined organic layers are washed with brine, dried over MgS04, filtered, concentrated under reduced pressure and dried to yield Fmoc- Val- Ala-OH. This product is suspended in dry DCM (25 ml), PABA (0.785 g, 6.38 mM) and EEDQ (1.971 g, 7.97mM) are added. The resulting mixture is treated under Argon with methanol until a clear solution is obtained. The reaction is stirred overnight and filtered. The filtrate is washed with diethyl ether (4x) and dried under high vacum to yield EC 1930 (1.85 g, 68%). 1H NMR (500 MHz, CD3OD): delta 7.79 (d, = 8.0 Hz, 2H), 7.65 (t, = 7.0 Hz, J2= 7.5 Hz, 2H), 7.54 (d, = 8.0 Hz, 2H), 7.38 (t, = 7.5 Hz, J2= 7.5 Hz, 2H), 7.33-7.24 (m, 4H), 4.54 (s, 2H), 4.48 (q, J = 14.0 Hz, J2= 7.0 Hz, 1H), 4.42-4.32 (m, 2H), 4.22 (t, J1=7.0 Hz, J2= 6.5 Hz, 1H), 3.94 (d, Ji= 7.0 Hz, 1H), 2.07 (m, 1H), 1.43 (d, Jl=7.5 Hz, 3H), 0.97 (d, Jl=7.0 Hz, 3H), 0.95 (d, Ji= 7.0 Hz, 3H); LCMS (ESI): (M + H)+= Calculated for C30H33N3O5, 516.24; found 516.24
	With sodium carbonate; In 1,4-dioxane; water; at 0 - 20℃; for 18h;	To a solution of <strong>[1115-74-8]Val-Ala</strong>-OH (1 g, 5.31 mM) in water (40 ml) was added Na2CO3 (1.42 g, 13.28 mM) and cooled to 0C before dioxane (40 mL) was added. A solution of Fmoc-Cl (1.44 g, 5.58 mM) in dioxane (40 mL) was added dropwise over 10 mm at 0C. The reaction mixture was stirred at 0C for 2h. Then the reaction mixture was allowed to stir at RT for 16 h. Dioxanewas removed under vacuum, the reaction mixture diluted with water (450 mL), pH was adjusted to 2 using iN HC1 and extracted with EtOAc (3 x 250 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered, concentrated under reduced pressure and dried to yield Fmoc-<strong>[1115-74-8]Val-Ala</strong>-OH. This product was suspended in dry DCM (25 ml), PABA (0.785 g, 6.38 mM) and EEDQ (1.971 g, 7.97mM) were added. The resulting mixture was treated underArgon with methanol until a clear solution was obtained. The reaction was stuffed overnight andfiltered. The filtrate was washed with diethyl ether (4x) and dried under high vacum to yieldEC1930 (1.85 g, 68%). ?H NMR (500 MHz, CD3OD): 5 7.79 (d, J,= 8.0 Hz, 2H), 7.65 (t, J,=7.0 Hz, J2= 7.5 Hz, 2H), 7.54 (d, J,= 8.0 Hz, 2H), 7.38 (t, J,= 7.5 Hz, J2= 7.5 Hz, 2H), 7.33-7.24 (m, 4H), 4.54 (s, 2H), 4.48 (q, J,= 14.0 Hz, J2= 7.0 Hz, 1H), 4.42-4.32 (m, 2H), 4.22 (t,J,= 7.0 Hz, J2= 6.5 Hz, 1H), 3.94 (d, J,= 7.0 Hz, 1H), 2.07 (m, 1H), 1.43 (d, J,= 7.5 Hz, 3H),0.97 (d, J,= 7.0 Hz, 3H), 0.95 (d, J,= 7.0 Hz, 3H); LCMS (ESI): (M + H) = Calculated for C30H33N305, 516.24; found 516.24
	With sodium carbonate; In 1,4-dioxane; water; at 0 - 20℃; for 18h;	To a solution of <strong>[1115-74-8]Val-Ala</strong>-OH (1 g, 5.31 mM) in water (40 ml) was added Na2CO3 (1.42 g, 13.28 mM) and cooled to 0C before dioxane (40 mL) was added. A solution of Fmoc-Cl (1.44 g, 5.58 mM) in dioxane (40 mL) was added dropwise over 10 mm at 0C. The reaction mixture was stirred at 0C for 2h. Then the reaction mixture was allowed to stir at RT for 16 h.Dioxane was removed under vacuum, the reaction mixture diluted with water (450 mL), pH was adjusted to 2 using iN HC1 and extracted with EtOAc (3 x 250 mL). The combined organic layers were washed with brine, dried over Mg504, filtered, concentrated under reduced pressure and dried to yield Fmoc-<strong>[1115-74-8]Val-Ala</strong>-OH. This product was suspended in dry DCM (25 ml), PABA (0.785 g, 6.38 mM) and EEDQ (1.97 1 g, 7.97mM) were added. The resulting mixture was treated under Argon with methanol until a clear solution was obtained. The reaction was stirred overnight and filtered. The filtrate was washed with diethyl ether (4x) and dried under high vacum to yield Compound 48 (1.85 g, 68%). ?H NMR (500 MHz, CD3OD): (57.79 (d, J,= 8.0 Hz, 2H), 7.65 (t, J,= 7.0 Hz, J2= 7.5 Hz, 2H), 7.54 (d, J,= 8.0 Hz, 2H), 7.38 (t, J,= 7.5 Hz, J2=7.5 Hz, 2H), 7.33-7.24 (m, 4H), 4.54 (s, 2H), 4.48 (q, J,= 14.0 Hz, J2= 7.0 Hz, 1H), 4.42-4.32(m, 2H), 4.22 (t, J,= 7.0 Hz, J2= 6.5 Hz, 1H), 3.94 (d, J,= 7.0 Hz, 1H), 2.07 (m, 1H), 1.43 (d,J,= 7.5 Hz, 3H), 0.97 (d, J,= 7.0 Hz, 3H), 0.95 (d, J,= 7.0 Hz, 3H); LCMS (ESI): (M + H) =Calculated for C30H33N305, 516.24; found 516.24.
	With sodium carbonate; In 1,4-dioxane; water; at 0 - 20℃; for 18h;	To a solution of<strong>[1115-74-8]Val-Ala</strong>-OH (1 g, 5.31 mM) in water (40 ml) was addedNa2C03 (1.42 g, 13.28 mM) and cooled to 0C before dioxane (40 mL) was added. A solutionofFmoc-Cl (1.44 g, 5.58 mM) in dioxane (40 mL) was added dropwise over 10 min at 0C. Thereaction mixture was stirred at 0C for 2h, then allowed to stir at R T for 16 h. Dioxane was20 removed under vacuum, the reaction mixture diluted with water (450 mL), pH was adjusted to 2using 1N HCl and extracted with EtOAc (3 x 250 mL). The combined organic layers arewashed with brine, dried over MgS04, filtered, concentrated under reduced pressure and driedto yield Fmoc-<strong>[1115-74-8]Val-Ala</strong>-OH. This product was suspended in dry DCM (25 ml), PABA (0.785 g,6.38 mM) and EEDQ (1.971 g, 7.97mM) are added. The resulting mixture was treated under25 Argon with methanol until a clear solution was obtained. The reaction was stirred overnight andfiltered. The filtrate was washed with diethyl ether ( 4x) and dried under high vacum to yieldCompound 18 (1.85 g, 68%). 1H NMR (500 MHz, CD30D): J 7.79 (d, h= 8.0 Hz, 2H), 7.65 (t,h= 7.0 Hz, h= 7.5 Hz, 2H), 7.54 (d, h= 8.0 Hz, 2H), 7.38 (t, h= 7.5 Hz, h= 7.5 Hz, 2H), 7.337.24 (m, 4H), 4.54 (s, 2H), 4.48 (q, lF 14.0 Hz, h= 7.0 Hz, 1H), 4.42-4.32 (m, 2H), 4.22 (t,lF 7.0 Hz, h= 6.5 Hz, 1H), 3.94 (d, lF 7.0 Hz, 1H), 2.07 (m, 1H), 1.43 (d, lF 7.5 Hz, 3H),0.97 (d, h= 7.0 Hz, 3H), 0.95 (d, h= 7.0 Hz, 3H); LCMS (ESI): (M + Ht =Calculated forC3oH33N30s, 516.24; found 516.24

References: [1]Patent: WO2014/57073,2014,A1 .Location in patent: Page/Page column 123; 124.
[2]Patent: WO2014/57072,2014,A1 .Location in patent: Page/Page column 43.
[3]Patent: WO2014/96365,2014,A1 .Location in patent: Page/Page column 200-201.
[4]Patent: WO2014/130879,2014,A2 .Location in patent: Page/Page column 124; 125.
[5]Patent: WO2015/52533,2015,A1 .Location in patent: Page/Page column 47; 48.
[6]Patent: WO2015/52321,2015,A1 .Location in patent: Page/Page column 116.
[7]Patent: WO2015/52535,2015,A1 .Location in patent: Page/Page column 47.
[8]Patent: WO2015/52532,2015,A1 .Location in patent: Page/Page column 49.
[9]Patent: WO2015/155345,2015,A1 .Location in patent: Paragraph 0478.
[10]Patent: WO2015/159076,2015,A1 .Location in patent: Page/Page column 162; 163.
[11]Patent: WO2013/53873,2013,A1 .Location in patent: Page/Page column 89.
[12]Patent: WO2016/85967,2016,A1 .Location in patent: Page/Page column 49.
[13]Patent: WO2016/148674,2016,A1 .Location in patent: Page/Page column 116; 117.
[14]Patent: WO2017/172930,2017,A1 .Location in patent: Page/Page column 137; 138.
[15]Patent: WO2017/205661,2017,A1 .Location in patent: Page/Page column 51; 53; 54.

22
[ 1115-74-8 ]
[ 1430806-08-8 ]

References: [1]Patent: WO2013/55993,2013,A1 .

23
[ 1115-74-8 ]
[ 1430806-15-7 ]

References: [1]Patent: WO2013/55993,2013,A1 .

24
[ 68858-20-8 ]
[ 35661-39-3 ]
[ 1115-74-8 ]

References: [1]Structural Chemistry,2013,vol. 24,p. 1461 - 1471.

25
[ 1115-74-8 ]
[ 1599447-58-1 ]

References: [1]Patent: WO2014/57073,2014,A1 .
[2]Patent: WO2014/96365,2014,A1 .

26
[ 1115-74-8 ]
[ 1599447-59-2 ]

References: [1]Patent: WO2014/57073,2014,A1 .
[2]Patent: WO2014/96365,2014,A1 .

27
[ 1115-74-8 ]
[ 1599447-60-5 ]

References: [1]Patent: WO2014/57073,2014,A1 .
[2]Patent: WO2014/96365,2014,A1 .

28
[ 1115-74-8 ]
[ 1599447-61-6 ]

References: [1]Patent: WO2014/57073,2014,A1 .
[2]Patent: WO2014/96365,2014,A1 .

29
[ 1115-74-8 ]
[ 1599447-62-7 ]

References: [1]Patent: WO2014/57073,2014,A1 .

30
[ 1115-74-8 ]
[ 1599447-63-8 ]

References: [1]Patent: WO2014/57073,2014,A1 .

31
[ 1115-74-8 ]
[ 1599447-64-9 ]

References: [1]Patent: WO2014/57073,2014,A1 .

32
[ 1115-74-8 ]
[ 1595275-09-4 ]

References: [1]Patent: WO2014/57073,2014,A1 .
[2]Patent: WO2014/96365,2014,A1 .

33
[ 1115-74-8 ]
C₅₆H₇₁N₅O₁₀Si [ No CAS ]

References: [1]Patent: WO2014/96365,2014,A1 .

34
[ 1115-74-8 ]
C₆₂H₈₅N₅O₁₀Si₂ [ No CAS ]

References: [1]Patent: WO2014/96365,2014,A1 .

35
[ 1115-74-8 ]
C₅₃H₆₅N₅O₁₀Si [ No CAS ]

References: [1]Patent: WO2014/96365,2014,A1 .

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 1115-74-8

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CAS No.: 1115-74-8

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Product Details of [ 1115-74-8 ]

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Application In Synthesis of [ 1115-74-8 ]

[ 1115-74-8 ] Synthesis Path-Downstream 1~35

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