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Chemical Structure| 1112982-73-6 Chemical Structure| 1112982-73-6

Structure of 1112982-73-6

Chemical Structure| 1112982-73-6

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Product Details of [ 1112982-73-6 ]

CAS No. :1112982-73-6
Formula : C8H10BrClN2
M.W : 249.54
SMILES Code : CC(NC1=CC(Br)=CN=C1Cl)C
MDL No. :MFCD22628164

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Application In Synthesis of [ 1112982-73-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1112982-73-6 ]

[ 1112982-73-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1112982-73-6 ]
  • [ 885069-14-7 ]
  • [ 1112980-55-8 ]
YieldReaction ConditionsOperation in experiment
35% With potassium carbonate;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 100℃; for 1.66667h; Step 2. N-(6-(6-chloro-5-(isopropylamino)pyridin-3-yl)benzo[d1thiazol-2-yl)acetamide; 5-bromo-2-chloro-N-isopropylpyridin-3-amine (127.6 mg, 0.51 1 mmol), N-(6-(4,4,5,5-tetramethyl-l ,3,2- dioxaborolan-2-yl)benzo[d]thiazol-2-yl)acetamide (191.5 mg, 0.602 mmol), potassium carbonate (317.8 mg, 2.299 mmol), and Pd(dppf)Cl2-DCM complex (42.9 mg, 0.0526 mmol) were suspended in 1,2- dimethoxyethane (2.0 ml) and water (0.5 ml). Argon was bubbled through the suspension for about 15 seconds, and then the flask was fit with a reflux condensor and placed in a preheated oil bath (100 C) and stirred under argon for 100 minutes. The reaction was cooled to room temperature, concentrated, and treated with DCM and MeOH. These organic washings were decanted, concentrated, treated with water, and filtered. The solid was washed with water and the filtrate was discarded. Solid also washed with <n="79"/>MeOH and Et2O, but the filtrate and solid contain product. The solid and filtrate were combined, concentrated, and purified on a silica gel column (25: 1 to 20: 1 DCM / MeOH to 15: 1 DCM / 2 N ammonia in MeOH) to afford N-(6-(6-chloro-5-(isopropylamino)pyridin-3-yl)benzo[d]thiazol-2- yl)acetamide (64.5 mg, 35% yield). MS (ESI pos. ion) m/z: 361. Calculated exact mass for C17H17ClN4OS 360.
 

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