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Chemical Structure| 1108172-95-7 Chemical Structure| 1108172-95-7

Structure of 1108172-95-7

Chemical Structure| 1108172-95-7

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Product Details of [ 1108172-95-7 ]

CAS No. :1108172-95-7
Formula : C11H20N2O2
M.W : 212.29
SMILES Code : O=C(N1[C@H](CN)[C@@]2([H])C[C@@]2([H])C1)OC(C)(C)C
MDL No. :MFCD31696553

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Application In Synthesis of [ 1108172-95-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1108172-95-7 ]

[ 1108172-95-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1108172-95-7 ]
  • [ 166599-84-4 ]
  • [ 1108172-98-0 ]
YieldReaction ConditionsOperation in experiment
To a solution of the respective carboxylic acid (0.85 mmol) in DMF (4.0 mL) is added successively DIPEA (2.40 mmol) and TBTU (0.97 mmol). The obtained mixture is stirred for 10 min and treated with a solution of (lS,2S,5R)-2-Aminomethyl-3-aza- bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester (0.84 mmol) in DMF (1.5 mL). After LC-MS indicated complete conversion (10 min - 16 h) sat. aq. NaHCOs solution and ether (50 mL) are added, the layers are separated and the aq. layer is extracted twice with ether. The combined organic layers are washed twice with sat. NaHCC>3 solution, twice with citric acid (5% in water) and once with brine. After drying over MgSO4 and removal of solvents in vacuo the respective amide is obtained which is either purified by FC (EtO Ac/heptane) or used without further purification.; (lS,2S,5R)-2-[(Benzofuran-4-carbonyl)-amino]-methyl}-3-aza- bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester (method A) prepared by reaction of (lS,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hexane- 3-carboxylic acid tert-butyl ester with <strong>[166599-84-4]benzofuran-4-carboxylic acid</strong> (M.A. Eissenstat et al. J. Med. Chem. 1995, 38, 3094-3105). LC-MS (basic): tR = 0.91 min; [M+H]+ = 357.2.
 

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