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Chemical Structure| 1106313-60-3 Chemical Structure| 1106313-60-3

Structure of 1106313-60-3

Chemical Structure| 1106313-60-3

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Product Details of [ 1106313-60-3 ]

CAS No. :1106313-60-3
Formula : C18H21BClNO4S
M.W : 393.69
SMILES Code : O=S(C1=CC=CC=C1)(NC2=CC(B3OC(C)(C)C(C)(C)O3)=CC=C2Cl)=O

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Application In Synthesis of [ 1106313-60-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1106313-60-3 ]

[ 1106313-60-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 17321-93-6 ]
  • [ 1106313-60-3 ]
  • [ 1106312-90-6 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 100℃; for 0.75h;Microwave irradiation; Example 1-50: N-[5-(2-Amino-4-methyl-pyrimidin-5-yl)-2-chloro-phenyl]-benzenesulfonamide; N-[2-Chloro-5-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)-phenyl]-benzenesulfonamide (Intermediate B) (50 mg, 0.13 mmol), 5-Bromo-4-methyl-pyrimidin-2-ylamine (Intermediate C) (26 mg, 0.14 mmol) and PdCl2(dppf).DCM (10 mg, 0.013 mmol) are <n="56"/>placed in a microwave vial containing degassed DME (3 ml) and 2M Na2COs (1 ml). The resulting mixture is heated using microwave radiation at 100° C for 45 minutes. The reaction mixture is diluted with DCM, MgSpsi4 is added and the mixture is filtered through Celite.(R). (filter agent). The filtrate is absorbed onto silica and purification by flash chromatography on silica eluting with MeOH:DCM (1percent to 2percent MeOH) affords the title compound.
 

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