110568-64-4|6-Nitroisoindolin-1-one| Ambeed

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Quality Control of [ 110568-64-4 ] Purity: 96% SDS Specification

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Product Details of [ 110568-64-4 ]

CAS No. :	110568-64-4
Formula :	C₈H₆N₂O₃
M.W :	178.15
SMILES Code :	O=C1NCC2=C1C=C([N+]([O-])=O)C=C2
MDL No. :	MFCD03093931
InChI Key :	QKFIHDGZIPOWKP-UHFFFAOYSA-N
Pubchem ID :	22220920

Safety of [ 110568-64-4 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Computational Chemistry of [ 110568-64-4 ] Show Less

Physicochemical Properties

Num. heavy atoms	13
Num. arom. heavy atoms	6
Fraction Csp3	0.12
Num. rotatable bonds	1
Num. H-bond acceptors	3.0
Num. H-bond donors	1.0
Molar Refractivity	50.22
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	74.92 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	1.01
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	0.6
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	0.31
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	0.04
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-0.36
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	0.32

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-1.6
Solubility	4.5 mg/ml ; 0.0252 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-1.75
Solubility	3.19 mg/ml ; 0.0179 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-2.27
Solubility	0.961 mg/ml ; 0.0054 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	No
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	No
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-6.96 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	1.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	2.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<1.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	1.67

Application In Synthesis of [ 110568-64-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 110568-64-4 ]

[ 110568-64-4 ] Synthesis Path-Downstream 1~22

1
[ 420-37-1 ]
[ 110568-64-4 ]
[ 110568-72-4 ]

References: [1]Chemische Berichte,1988,vol. 121,p. 243 - 252.

2
[ 368-39-8 ]
[ 110568-64-4 ]
[ 110568-74-6 ]

References: [1]Chemische Berichte,1988,vol. 121,p. 243 - 252.

3
[ 110568-91-7 ]
[ 110568-64-4 ]

References: [1]Chemische Berichte,1988,vol. 121,p. 243 - 252.

4
[ 5415-18-9 ]
[ 110568-64-4 ]

References: [1]Chemische Berichte,1988,vol. 121,p. 243 - 252.

5
[ 133446-99-8 ]
[ 110568-64-4 ]

Yield	Reaction Conditions	Operation in experiment
92%	With ammonia; In methanol; at 20℃; for 2h;	2- (bromomethyl) -4-nitrobenzoate (250mg, 0.92 mmol) was added to a saturated methanolic ammonia (NH3) in (5mL red, stirred at room temperature for 2 hours, TLC the reaction was complete. Save the solvent was distilled off pressure, to the residue was added ethyl acetate (7mL) and sonicated for 3 minutes, placed in -20 C freezer for 3 minutes, a large number of solid, filtered and dried under high vacuum to give a pale yellow solid 150mg, yield 92%
	With ammonia; In methanol; at 20℃; for 2h;	5-Nitro-2,3-dihydroisoindol-l-one02N; [695] AIBN (58.6mg, 0.357mmol), NBS (785mg, 4.46mmol), and 2-methyl-4-nitrobenzoic acid methyl ester (696mg, 3.57mmol) were suspended in CC14 (35mL) in asealed tube. The above mixture was flushed with N2 for 5min and heated at 80C for 22h.After cooling, the solid was filtered off and the filtrate was concentrated to dryness to obtain acrude light-brown solid. To above solid was added NH3 (7 N in MeOH, 5mL), and themixture was stirred at rt for 2h and concentrated in vacua to obtain a yellow solid. This crudesolid was triturated with EtOAc (15mL) and was then cooled at -20 C. The mixture wasfiltered to obtain the title compound as yellow solid. 'H NMR (DMSO-^, 400 MHz): 5 =4.51 (s, 2 H), 7.13 (bra, 2 H), 7.91 (d, 1 H, J= 8.4 Hz), 8.25 (dd, 1 H, J= 2.0 & 8.4 Hz), 8.48(d, 1 H, J= 2.0 Hz), 9.04 (brs, 1 H). MS (ES+): m/z 179.22 (100) [MH1]. HPLC: fe = 2.14min (ZQ2000, polar_5 min).
	With ammonia; In methanol; at 20℃; for 2h;	Step B: 5-nitroisoindoiin-1 -one A suspension of <strong>[133446-99-8]methyl <strong>[133446-99-8]2-(bromomethyl)-4-nitrobenzoate</strong></strong> in ammonium solution (7 N in methanol, 5 mL) was stirred at room temperature for 2 hours and concentrated in vacuum to obtain a yellow solid. This crude solid was triturated with ethyl acetate (15 mL) and was then cooled at -20 C. The mixture was filtered to obtain the product 5-nitroisoindolin-1 -one as yellow solid. N R (400 MHz, DMSO-d6) delta ppm 9.04 (br s, 1 H), 8.48 (d, 1 H, J = 2.0 Hz), 8.25 (dd, 1 H, J = 2.0 Hz, 8.4 Hz), 7.91 (d, 1 H, J = 8.4 Hz), 4.51 (s, 2 H).

	With ammonium hydroxide; ammonia; In methanol; at 20℃;	Crude 7C (70 g, 0.26 mol) was suspended in 2M NH3inMeOH (700 mL) and concentratedammonium hydroxide (250 mL) at room temperature overnight. The mixturewasfilteredto affordcrude 7D (35g) as a white solid.
	With ammonia; In methanol; at 20℃;	Step 3: Synthesis of 5-Nitro-2,3-dihydro-isoindol-1-one The crude from the previous step (4 g) was placed in a 100 ml round bottom flask, then a solution of 7N NH3 in MeOH was added. The mixture was stirred at room temperature, overnight. The mixture was concentrated down to a solid residue, then triturated with 75 ml ethylacetate. The suspension was filtered off, solid was dried to give 1.8 g product, pure by HNMR, 64% over 2 steps yield.

References: [1]Patent: CN103804358,2016,B .Location in patent: Paragraph 0123.
[2]Patent: WO2006/17443,2006,A2 .Location in patent: Page/Page column 155.
[3]Patent: WO2012/92880,2012,A1 .Location in patent: Page/Page column 57.
[4]Patent: WO2015/81891,2015,A1 .Location in patent: Page/Page column 138; 139.
[5]Patent: US9138427,2015,B2 .Location in patent: Page/Page column 287.

6
[ 110568-64-4 ]
[ 222036-66-0 ]

Yield	Reaction Conditions	Operation in experiment
84%	With hydrogenchloride; iron; In ethanol; water; for 2h;Heating;	A mixture of 5-nitro-1 lead noise isobutyl ketone Jie (100mg, 0.56mmoL), reduced iron powder (314mg, 5.6mmoL) was added to ethanol (2. OmL) and concentrated hydrochloric acid (0.5mL) and heated under reflux for 2 hours , TLC the reaction was complete. Cooling, the methanol solution saturated with ammonia (NH3) neutralizing the acid, diatomaceous earth filtration, washed with methanol, the solvent evaporated under reduced pressure to give a white solid 70.0mg, 84% yield
76.2%	With hydrogen;palladium 10% on activated carbon; In methanol; for 1h;	Step C / Intermediate B8: 5-aminoisoindoiin-1 -oneTo a solution of 5-nitroisoindolin-1 -one (60 mg, 0.337 mmoi) in methanol (20 mL) was added palladium on carbon (10 %, 50 mg). The mixture was stirred under an atmosphere of hydrogen for 1 hour. Filtration through Celite, followed by concentration led to 5-aminoisoindoiin-1 -one as a tan solid (38 mg, yield 78.2 %).
48%	With iron; ammonium chloride; In ethanol; water; at 80℃; for 2h;	Step 4: Synthesis of 5-Amino-2,3-dihydro-isoindol-1-one To a suspension of Fe (1.1 g, 19.6 mmole), NH4Cl (1.5 g, 28 mmole) in a mixture of ethanol/water (30 ml/7 ml) at 80 C. was added a mixture of 5-Nitro-2,3-dihydro-isoindol-1-one (1 g, 5.6 mmole) in 10 ml ethanol. The reaction mixture was stirred at 80 C. for 2 hours. Mixture was cooled down, filtered off, solid was washed with 50 ml ethanol. The filtrate was concentrated, taken into 50 ml ethylacetate, washed with 20 ml water. Organic layer was dried over Na2SO4, filtered and concentrated to give about 900 mg crude. Trituration with methyl t-butylether gave 400 mg pure product, 48% yield. A 18 ml vial was loaded with a mixture of 30% H2O2 (1 ml), 3N NaOH (3 ml) and MeOH (2.5 ml). To this mixture 5-Amino-pyridine-2-carbonitrile (450 mg, 3.78 mmole) was added at room temperature. Reaction mixture was stirred at rt for 45 minutes, TLC showed the starting material to be consumed. The mixture was diluted with water and filtered; the solid was washed with water and dried to give 480 mg product, 92% yield.

	With hydrogenchloride; ethanol; water; iron; at 95℃; for 2h;	5-Amino-2,3-dihydroisoindol-l-oneH2N; [693] Iron powder (158mg, 2.83mmol), water (61uL), and HC1 (37%, 5uL,0.566mmol) were added into the suspension of 5-nitro-2,3-dihydroisoindol-l-one (50.4mg,0.283mmol) in EtOH (754\|^L). The above mixture was heated at 95C for 2h. After thattime, several drops of 7N NH3 in MeOH were added to basify the solution, and the solid wasfiltered off. The filtrate was concentrated in vacua to obtain a light-yellow solid that waspurified by preparative TLC eluting with 10% MeOH/CH2Cl2 to give a light-yellow solid of5-amino-2,3-dihydroisoindol-l-one. 'HNMR (CD3OD, 400 MHz): 5 = 7.48 (s, 1 H), 8.08 (s,2 H), 9.91 (s, 1 H), 10.66 (d, 1 H, J= 8.8 Hz). MS (ES+): m/z 149.21 (100) [MH1"]. HPLC: *R= 1.20 min (ZQ2000, polar_5 min).
	With hydrogen;palladium on activated charcoal; In methanol; for 1h;Inert atmosphere;	To a solution of <strong>[110568-64-4]5-nitro-2,3-dihydro-1H-isoindol-1-one</strong> (60 mg, 0.337 mmol) in methanol (20 mL) was added 50 mg of 10% Pd on carbon. The mixture was hydrogenated (with a balloon) for 1 hour. Filtration through Celite followed by concentration led to 38 mg of 5-amino-2,3-dihydro-1H-isoindol-1-one as a tan solid.
		Step 3: 5-aminoisoindolin-1-oneIron powder (2.51 g, 45 mmol), water (0.97 ml) and HCl (37%, 0.74 ml), were added to a stirred suspension of the <strong>[110568-64-4]5-nitroisoindolin-1-one</strong> (800 mg, 4.5 mmol) from step 2 of this example in EtOH (11.2 ml). The mixture was heated at 95 C for 2h. Ammonia (7N in MeOH) was added (ImL) to make the pH of the mixture alkaline. The mixture was filtered to removed undissolved solids and the filter cake washed with EtOH (2x40 ml). The filtrate and organic washes were combined and concentrated in vacuum to give the titled compound.
	With palladium on activated charcoal; hydrogen; In methanol; at 50℃; under 2585.81 Torr; for 2h;	Toa solution of7D (35 g, 0.2 mol) in MeOH(350 mL) was added Pd/C (7 g), the mixture was stirred at 50C underH2 at 50 psi for 2 hr.Themixturewas filtered and concentratedin vacuumto afford crude7E (30g) as a white solid.

References: [1]Patent: CN103804358,2016,B .Location in patent: Paragraph 0126.
[2]Patent: WO2012/92880,2012,A1 .Location in patent: Page/Page column 57.
[3]Patent: US9138427,2015,B2 .Location in patent: Page/Page column 287.
[4]Patent: WO2006/17443,2006,A2 .Location in patent: Page/Page column 154-155.
[5]Patent: US2010/15141,2010,A1 .Location in patent: Page/Page column 26.
[6]Patent: WO2011/19538,2011,A1 .Location in patent: Page/Page column 128.
[7]Patent: WO2015/81891,2015,A1 .Location in patent: Page/Page column 138; 139.

7
[ 62621-09-4 ]
[ 110568-64-4 ]

Yield	Reaction Conditions	Operation in experiment
		A mixture of <strong>[62621-09-4]methyl 2-methyl-4-nitrobenzoate</strong> (696 mg, 3.57 mmol), 2,2'-azobis(2-methylpropionitrile (59 mg, 0.357 mmol), and N-bromosuccinimide (785 mg, 4.46 mmol) in CCl4 (35 mL) in a sealed tube was flushed with N2 for 5 minutes, and heated at 80 C. for 24 hours. The mixture was filtered through Celite, and the filtrate was concentrated. To the residue was added 7 mL saturated ammonium in methanol. The mixture was stirred at room temperature for 2 hours, and concentrated. The residue was triturated with ethyl acetate, and the product was collected by filtration to give 100 mg of 5-nitro-2,3-dihydro-1H-isoindol-1-one as a light tan solid.
		Step 2 : 5 -nitroisoindolin- 1 -oneAIBN (84 mg, 0.51), NBS (1.1 gram, 6.4 mmol), and the <strong>[62621-09-4]methyl 2-methyl-4-nitrobenzoate</strong> (1 g, 5.1 mmol) from step 1 of this example were suspended in CCLt and the mixture heated under N2 at 79 C overnight. The solution was filtered, and concentrated in vacuum. The residue was dissolved in 7 N ammonia in methanol (15 ml) and the solution stirred for 2 hours at RT. The mixture was concentrated in vacuum, and the resulting solid suspended in EtOAc (21.5 ml), heated at 80 C for 30 minutes with stirring, cooled RT and aged at -20 C for the 3 days. The solid was isolated by filtration to give the titled compound.

References: [1]Patent: US2010/15141,2010,A1 .Location in patent: Page/Page column 26.
[2]Patent: WO2011/19538,2011,A1 .Location in patent: Page/Page column 127-128.
[3]Patent: WO2015/81891,2015,A1 .
[4]Patent: US9138427,2015,B2 .
[5]Patent: CN103804358,2016,B .
[6]Patent: WO2012/92880,2012,A1 .

8
[ 133446-99-8 ]
[ 110568-64-4 ]

Yield	Reaction Conditions	Operation in experiment
	With ammonia; triethylamine; In methanol; for 24h;Reflux;	Step c:[00295] A mixture of 2-Bromomethyl-4-nitro-benzoic acid methyl ester (leq.) an appropriate amine (1.1 eq.), Et3N (l.leq), and 10 mL of methanol is refluxed for 24hrs. The mixture is diluted with EtOAc, washed with HCl (IN) and brine, dried over MgSO4, and evaporated. The residue is purified by flash chromatography. to afford the expected compound.

References: [1]Patent: WO2010/10184,2010,A1 .Location in patent: Page/Page column 59.

9
[ 1975-51-5 ]
[ 110568-64-4 ]

References: [1]Patent: WO2011/19538,2011,A1 .
[2]Patent: WO2015/81891,2015,A1 .
[3]Patent: US9138427,2015,B2 .
[4]Patent: CN103804358,2016,B .

10
[ 110568-64-4 ]
[ 1266336-32-6 ]

References: [1]Patent: WO2011/19538,2011,A1 .

11
C₃₂H₂₅N₅O₇ [ No CAS ]
[ 71247-27-3 ]
[ 110568-64-4 ]

References: [1]RSC Advances,2015,vol. 5,p. 106156 - 106160.

12
2-(azidomethyl)-4-nitrobenzoyl chloride [ No CAS ]
[ 110568-64-4 ]

References: [1]RSC Advances,2015,vol. 5,p. 106156 - 106160.

13
[ 110568-64-4 ]
2-methyl-2-[(1-oxo-isoindol-5-yl)-amino]propanenitrile [ No CAS ]

References: [1]Patent: CN103804358,2016,B .

14
[ 110568-64-4 ]
4-[4,4-dimethyl-5-oxo-3-(1-oxo-isoindoline-5-yl)-2-thioxo-imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile [ No CAS ]

References: [1]Patent: CN103804358,2016,B .

15
[ 24424-99-5 ]
[ 110568-64-4 ]
tert-butyl 5-nitro-1-oxoisoindoline-2-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
61%	With dmap; In 1,4-dioxane; at 20℃;Inert atmosphere;	To a solution of 5-nitroisoindolin-l-one (600 mg, 3.37 mmol) in dioxane (30 mL) under a nitrogen atmosphere was added DMAP (616 mg, 5.05 mmol) followed by di-to -butyl dicarbonate (1.16 mL, 5.05 mmol). The resulting reaction mixture was stirred at room temperature overnight, then poured onto water and extracted with EtOAc (3X). The combined organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude residue was purified by chromatography (20% EtOAc in hexanes eluent followed by 20:20:80 DCM: EtOAc: hexane eluent) to provide tot-butyl 5-nitro-l-oxoisoindoline-2-carboxylate (576 mg, 61% yield) as a white solid. NMR (300 MHz, Chloroform-i ) delta 8.43 - 8.35 (m, 2H), 8.10 (d, J = 8.9 Hz, 1H), 4.90 (s, 2H), 1.64 (s, 9H).
57%	With dmap; In acetonitrile; at 20℃; for 12h;	Synthesis of tert-butyl 5-nitro-1-oxoisoindoline-2-carboxylate (2) To a stirred solution of <strong>[110568-64-4]5-nitroisoindolin-1-one</strong> (1, 0.4 g, 2.24 mmol) in acetonitrile (20 mL), N,N-dimethylaminopyridine (0.41 g, 3.37 mmol) followed by di-tert-butyl dicarbonate (0.75 mL, 3.37 mmol) were added. The reaction mixture was allowed to stir at room temperature for 12 h. The reaction mixture was quenched with water and extracted with ethyl acetate. The organic layer was washed with brine, separated, dried over sodium sulphate and concentrated under reduced pressure. The crude was purified by silica gel column chromatography using 25% ethyl acetate in hexane to afford tert-butyl 5-nitro-1-oxoisoindoline-2-carboxylate (2). Yield: 0.36 g, 57%; MS (ESI) m/z 279 [M+1]+.

References: [1]Patent: WO2018/136935,2018,A1 .Location in patent: Paragraph 00714; 00716.
[2]Patent: US10112955,2018,B2 .Location in patent: Page/Page column 75.

16
[ 110568-64-4 ]
tert-butyl 5-amino-1-oxoisoindoline-2-carboxylate [ No CAS ]

References: [1]Patent: WO2018/136935,2018,A1 .
[2]Patent: US10112955,2018,B2 .

17
[ 110568-64-4 ]
tert-butyl 1-oxo-5-(2,2,2-trifluoroacetamido)isoindoline-2-carboxylate [ No CAS ]