Structure of 1088-00-2
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
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CAS No. : | 1088-00-2 |
Formula : | C18H13P |
M.W : | 260.27 |
SMILES Code : | P1(C2=CC=CC=C2)C3=CC=CC=C3C4=C1C=CC=C4 |
MDL No. : | MFCD00046900 |
InChI Key : | DNPJAMMRVRYLOB-UHFFFAOYSA-N |
Pubchem ID : | 258370 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319 |
Precautionary Statements: | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | General procedure for the synthesis of dibenzophosphole ligands At -78 C, a solution of n-butyllithium (2.0 mmol, 2 equiv) in hexanes (1.1 mL) was added slowly to a solution of the 2,2'-dihalobiaryl (1.0 mmol) in tetrahydrofuran (2 mL). After 30 min, a solution of dichlorophenylphosphine (0.18 g, 0.14 mL, 1.0 mmol, 1 equiv) in toluene (1 mL) was added slowly. After 15 min, the reaction mixture was allowed to reach 25 C and was treated with a saturated aqueous solution of ammonium chloride (15 mL). The mixture was extracted with ethyl acetate (3*15 mL), and the combined organic layers were dried over sodium sulfate. Evaporation of the solvent followed by column chromatography on silica gel using cyclohexane as the eluent gave the corresponding dibenzophosphole. All analytical data were identical to those previously reported. 17 |