Structure of 1083327-58-5
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
4.5
*For Research Use Only !
Change View
Size | Price | VIP Price | US Stock |
Global Stock |
In Stock | ||
{[ item.pr_size ]} |
Inquiry
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.discount_usd) ]} {[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} |
Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]} | Inquiry {[ item.pr_usastock ]} In Stock Inquiry - | {[ item.pr_chinastock ]} {[ item.pr_remark ]} In Stock 1-2 weeks - Inquiry - | Login | - + | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
1-2weeks
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price, item.pr_usd) ]}
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 1083327-58-5 |
Formula : | C7H9BrN2O3S |
M.W : | 281.13 |
SMILES Code : | CS(=O)(NC1=CC(Br)=CN=C1OC)=O |
MDL No. : | MFCD22989195 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With caesium carbonate;copper(l) iodide; In water; N,N-dimethyl-formamide; at 105℃; for 20.0h; | EXAMPLE 119; N-(2-Methoxy-5-(4-morpholinoquinolin-6-yl)pyridin-3- yl)methanesulfonamide; (1) N-(5-Bromo-2-methoxypyridin-3-yl)methanesulfonamide.; To a 5 mL microwave vial, <strong>[578007-66-6]5-bromo-3-iodo-2-methoxypyridine</strong> (0.317 g, 1.01 mmol, Alfa Aesar, Ward Hill, MA), methanesulfonamide (0.100 g, 1.06 mmol), cesium carbonate (0.829 g, 2.54 mmol) and copper(I) iodide (0.0211 g, 0.111 mmol) were mixed into DMF (1 mL). water (0.1 mL) was added and the mixture was heated at 105 0C for 20 h. The reaction mixture was poured into water/Tris-lM HCl pH 7 buffer then IN HCl was added to bring pH to ~5. The aqueous phase was extracted with EtOAc (3 X 20 mL). The combined organic phases were washed with saturated aqueous NaCl (40 mL). The organic phase was dried over sodium sulfate, filtered and concentrated in vacuo. The crude product was purified by silica gel column chromatography (eluent: EtOAc in hexanes 0 % - 50 %) to afford an off white solid (0.135 g) as the desired product. MS (ESI pos. ion) m/z calcd for C7H9BrN2O3S: 280.0; found 280.8/282.8 [M+l/M+3]. 1H NMR (300 MHz, CHLOROFORM-^), delta ppm 3.04 (s, 3 H) 3.92 - 4.07 (m, 3 H) 6.74 (br. s., 1 H) 7.89 (d, J=2.19 Hz, 1 H) 7.97 (d, J=2.19 Hz, 1 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74% | A suspension of N-(5-bromo-2-methoxypyridin-3-yl)methanesulfonamide (3.35 g, 11.9 mmol) and 4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane) (4.24 g, 16.7 mmol, Beijing datianfengtuo) in toluene (100 mL) was degassed and charged with N2 for 3 times, then Pd(dba)3 (616 mg, 0.595 mmol, Matthey) and PPh3 (243 mg, 0.892 mmol) were added. The mixture was heated to 45 C. and stirred for 45 minutes, then KOAc (3.74 g, 23.8 mmol) was added. The resulted mixture was heated to reflux and stirred further for 3 hours, then cooled to rt, diluted with EtOAc (100 mL), and filtered through a CELITE. The filtrate was washed with water (70 mL*3) and brine (100 mL), dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v)=2/1) to give the title compound as a white solid (2.90 g, 74%). MS (ESI, pos. ion) m/z: 328.9 [M+H]+; 1H NMR (600 MHz, CDCl3): delta 8.32 (d, J=1.4 Hz, 1H), 8.06 (d, J=1.3 Hz, 1H), 6.66 (brs, 1H), 4.05 (s, 3H), 3.02 (s, 3H), 1.33 (s, 12H). | |
72% | With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100℃; for 4h;Inert atmosphere; | General procedure: A mixture of 16a (11.38 g, 30 mmol), bis(pinacolato)diboron (9.14 g, 36 mmol) and potassium acetate (5.89 g, 60 mmol) in 1,4-dioxane (200 mL) was degassed, and then PdCl2(dppf) (1.1 g, 1.5 mmol) was added. The reaction mixture was degassed and back-filled with argon (three cycles), stirred at 100 C under argon atmosphere for 4 h, and then cooled to room temperature. The resulting mixture was filtered and the filtrate was concentrated and purified with column chromatography (silica gel, PE/EtOAc = 7:1) to afford 17a as a pale yellow solid (12.69 g, 99% yield). |
60.4% | With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium acetate; In N,N-dimethyl-formamide; at 100℃; for 8h;Inert atmosphere; | A solution of the 2a (2.80 g, 10 mmol), bis(pinacolato)diborane(1.27 g, 5 mmol), Pd(dppf)2Cl2 (0.18 g, 0.25 mmol) and KOAc (1.47 g,15 mmol) in anhydrous DMF (30 ml) under N2 was stirred at 100 Cfor 8 h. DMF was removed under reduced pressure and add water(100 ml), extracted with ethyl acetate (3 100 ml), the organiclayer was washed with water (20 ml), dried with Na2SO4 andevaporated to give compound 3a as a white solid (1.98 g, 60.4%yield). mp 90e92 C. 1H NMR (400 MHz, DMSO) d 9.25 (s, 1H, NH),8.21 (d, J 1.6 Hz, 1H, Ar-H), 7.78 (d, J 1.6 Hz, 1H, Ar-H), 3.94 (s, 3H,OCH3), 3.01 (s, 3H, CH3), 1.30 (s, 12H, CH3). ESI-MS: m/z 329.1[MH]. |
60.4% | With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; In N,N-dimethyl-formamide; at 100℃; for 8h;Inert atmosphere; | A solution of the 2a(2.80 g, 10 mmol), bis(pinacolato)diborane (1.27 g, 5 mmol), Pd(dppf)2Cl2 (0.18 g, 0.25 mmol) and KOAc (1.47 g, 15 mmol) inanhydrous DMF (30 ml) under N2 was stirred at 100 C for 8 h.DMF was removed under reduced pressure and adding water(100 ml), extracted with ethyl acetate (3 100 ml), the organiclayer was washed with water (20 ml), dried with Na2SO4 and evaporatedto give compound 3a as a white solid (1.98 g, 60.4% yield).Mp 90-92 C. 1H NMR (400 MHz, DMSO) d 9.25 (s, 1H, NH), 8.21(d, J = 1.6 Hz, 1H, Ar-H), 7.78 (d, J = 1.6 Hz, 1H, Ar-H), 3.94 (s, 3H,OCH3), 3.01 (s, 3H, CH3), 1.30 (s, 12H, CH3). ESI-MS: m/z 329.1 [M+H]+. |
60.4% | With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In N,N-dimethyl-formamide; at 100℃; for 8h;Inert atmosphere; | General procedure: A solution of the 5a (2.80 g, 10 mmol), bis(pinacolato)diborane(1.27 g, 5 mmol), Pd(dppf)2Cl2 (0.18 g, 0.25 mmol) and KOAc (1.47 g,15 mmol) in anhydrous DMF (30 ml) under N2 was stirred at 100 C for8 h. Then DMF was removed under reduced pressure and add water(100 ml), extracted with ethyl acetate (200 ml) for two times, dried with anhydrous Na2SO4 and evaporated to get the residue which was purified through a column chromatography on silica with petroleum ether / ethyl acetate (V:V 5:1) to give compound 6a as a white solid(1.98 g, 60.4% yield). mp 90-92 C. 1H NMR (400 MHz, DMSO-d6) delta9.25 (s, 1H, NH), 8.21 (d, J=1.6 Hz, 1H, Ar-H), 7.78 (d, J=1.6 Hz,1H, Ar-H), 3.94 (s, 3H, OCH3), 3.01 (s, 3H, CH3), 1.30 (s, 12H, CH3).ESI-MS: m/z 329.1 [M+H]+. |
With potassium acetate;tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine; In toluene; at 90℃; for 1.16667h;Inert atmosphere; | Intermediate 16W-(2-Methoxy-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin-3- ideAll weights, volumes and equivalents are relative to A/-(5-bromo-2-methoxypyridin-3- yl)methanesulfonamide.Tricyclohexylphosphine (0.1 191 g, 0.425 mmol, 0.008eq, 0.008wt) and Pd2(dba)3 (0.1438 g, 0.157 mmol, 0.003 eq, 0.01 wt) are mixed together and then toluene (15.00 mL, 1 vol, 0.86wt, sparged with nitrogen for 1 hr) is added. The mixture is stirred and heated to 40- 45C for 45 mins before being allowed to cool back to room temp and sit under nitrogen to give an orange-gold solution with suspended black particulates. In a separate vessel, N- (5-bromo-2-methoxypyridin-3-yl)methanesulfonamide (15.0323 g, 53.5 mmol, 1 wt, 1 eq), bis(pinacolato)diboron (16.2962 g, 64.2 mmol, 1 .2 eq, 1.08 wt) and potassium acetate (10.4879 g, 107 mmol, 2 eq, 0.70 wt) are mixed together with toluene (150 mL, 10 vols, 8.6 wt). The resultant slurry is stirred and heated to 90 C under a flow of nitrogen. Having reached the desired temperature, the catalyst mixture is added over 10 minutes followed by a wash of toluene (7.50 mL, 0.5 vol, 0.43 wt). The mixture is stirred at 90 C for at least one hour and then sampled for HPLC analysis. Once complete, the reaction mixture is cooled to 50 C and filtered to remove inorganic material. The filtered solid is washed with toluene (2 x 15 mL, 2 x 1 vol, 2 x 0.86 wt) and the liquors and washes combined and distilled down to 5 vols. The product solution is allowed to cool to room temperature by which stage it has become a slurry. Heptane (75 mL, 5 vols, 3.4 wt) is slowly added to the slurry. The slurry is aged and the supernatant analysed by HPLC to ensure sufficient crystallisation has occurred. The slurry is filtered and the solid product is washed with 1 : 1 toluene: heptane (2 x 15mL, 2 x 1vol) and dried under vacuum at 40-50 C to afford N-(2- methoxy-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide as an off-white solid. | |
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; In 1,4-dioxane; N,N-dimethyl-formamide; at 110℃; for 2h;Sealed tube; Inert atmosphere; | General procedure: The following is based on a modified literature procedure (Knight S. D. et al., ACS Med. Chern. Let., 2010, 1, 39-43 and W02008 150827). To N-(5-bromo-2-methoxypyridin-3 -yI)methanesulphonamide(350 mg, 1.24 mmol) in dry 1,4-dioxane (9 mL)/dry DMF (1 mL) in a sealed tube was added, bis(pinacolato)diboron (347 mg, 1.37 mmol), KOAc (366 mg, 3.73 mmol), and the whole mixture was degassed and purged with N2. Pd(dppf)C12.CH2C12 (52 mg, 0.06mmol) was then added with vigorous stirring and the mixture heated to 110C for 2 h. The disappearance of the starting bromide was monitored by LRMS. This mixture was then allowed to cool to room temperature and used in situ without further purification. LRMS (APCI) calcd for C13H21BN205S 330 (M1-I), found 330 (boronate ester). | |
All weights, volumes and equivalents are relative to N-(S30 bromo-2-methoxypyridin-3-yl)methanesulfonamide.Tricyclohexylphosphine (0.1191 g, 0.425 mmol, 0.008 eq,0.008 wt) and Pd2(dba)3 (0.1438 g, 0.157 mmol, 0.003 eq,0.01 wt) are mixed together and then toluene (15.00 mE,vol, 0.86 wt, sparged with nitrogen for 1 hr) is added. Themixture is stirred and heated to 40-45 C. for 45 mins beforebeing allowed to cool back to room temp and sit under nitrogen to give an orange-gold solution with suspended blackparticulates. In a separate vessel, N-(S -bromo-2-methoxypy-ridin-3-yl)methanesulfonamide (15.0323 g, 53.5 mmol, 1 wt,eq), bis(pinacolato)diboron(16.2962 g, 64.2 mmol, 1.2 eq,1.08 wt) and potassium acetate (10.4879 g, 107 mmol, 2 eq,0.70 wt) are mixed together with toluene (150 mE, 10 vols,8.6 wt). The resultant slurry is stirred and heated to 90 C.under a flow ofnitrogen. Having reached the desired temperature, the catalyst mixture is added over 10 minutes followedby a wash oftoluene (7.50 mE, 0.5 vol, 0.43 wt). The mixtureis stirred at 90 C. for at least one hour and then sampled forHPEC analysis. Once complete, the reaction mixture iscooled to 50 C. and filtered to remove inorganic material.The filtered solid is washed with toluene (2x1 S mE, 2x 1 vol,2x0.86 wt) and the liquors and washes combined and distilleddown to S vols. The product solution is allowed to cool toroom temperature by which stage it has become a slurry.Heptane (75 mE, S vols, 3.4 wt) is slowly added to the slurry.The slurry is aged and the supernatant analysed by HPEC toensure sufficient crystallisation has occurred. The slurry isfiltered and the solid product is washed with 1:1 toluene:heptane (2x1 S mE, 2x1 vol) and dried under vacuum at40-S0 C. to afford N-(2-methoxy-S-(4,4,S,S-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide asan off-white solid.Recrystallisation-All weights, volumes and equivalentsare relative to N-(2-methoxy-S-(4,4,S,S-tetramethyl- 1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide.A stirred suspension of N-(2-methoxy-S-(4,4,S,S-tetram-ethyl-i ,3,2-dioxaborolan-2-yl)pyridin-3-yl)methane-sulfonamide (1 wt, 1.01 kg) in propan-2-ol (4 vol, 4.OS E) isheated to 70-75C. under a nitrogen atmosphere, then aged atthis temperature for at least 2 hr. The batch is allowed to cool to 20-25 C. over at least 1 hr, then the suspension is aged at this temperature for a further 1 hr. The liquors are sampled by HPLC to ensure complete crystallisation, then the resulting solids are filtered, washed with propan-2-ol (2x1 vol, 2x1.01 L) before being sucked dry for 0.5 hr, then the batch is dried in vacuo at 50 C. to constant probe temperature to afford N-(2-methoxy-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2- yl)pyridin-3-yl)methanesulfonamide as a white solid.5 | ||
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 120℃; for 3h;Inert atmosphere; | A solution of 0.32 g (1.15 mmol) of 3-methanesulfonamido-2-methoxy-5-bromopyridine0.34 g (1.38 mmol) of diphenylolate borate,0.04 g (3.48 mmol) of potassium acetate and 0.06 g (0.08 mmol) of Pd (dppf) Cl2 in 100 mL eggplant vials,Adding dioxane 12mL, nitrogen protection, heating at 120 reflux 3h,To give the product containing 3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -5-methanesulfonamido-6-methoxypyridine Of the reaction system, cooled to room temperature,To this system was added (S) -N1- (6-bromo-2-benzothiazolyl) -1,2-tetrahydropyrrole dicarboxamide, 35 g (0.96 mmol) of potassium carbonate, 0.48 g (3.45 mmol) of potassium carbonate,Pd (dppf) Cl2 0.11 g (0.14 mmol) and water (3 mL), protected under nitrogen, heated at 120 C for 7 h,(V / V): chloroform / methanol = 25/1 to give 0.05 g of a white solid, yield: 10.83%, mp: 190-194, and the residue was purified by flash chromatography on silica gel. . |
Tags: 1083327-58-5 synthesis path| 1083327-58-5 SDS| 1083327-58-5 COA| 1083327-58-5 purity| 1083327-58-5 application| 1083327-58-5 NMR| 1083327-58-5 COA| 1083327-58-5 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :
Total Compounds: mg
The concentration of the dissolution solution you need to prepare is mg/mL