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Chemical Structure| 1083051-56-2 Chemical Structure| 1083051-56-2

Structure of 1083051-56-2

Chemical Structure| 1083051-56-2

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Product Details of [ 1083051-56-2 ]

CAS No. :1083051-56-2
Formula : C16H17F4N3
M.W : 327.32
SMILES Code : CN1C=C(C2=CC=C(F)C(C(F)(F)F)=C2)N=C1C3CCNCC3

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Application In Synthesis of [ 1083051-56-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1083051-56-2 ]

[ 1083051-56-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1083051-56-2 ]
  • [ 663193-80-4 ]
  • [ 1428248-69-4 ]
YieldReaction ConditionsOperation in experiment
86% With potassium carbonate; In dimethyl sulfoxide; at 60.0℃; 5-Bromo-6-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1 -methyl-1 H-imidazol-2-yll-piperidin- 1 -yl)-pyrimidin-4-ylamine ("1 ")A mixture of <strong>[663193-80-4]5-bromo-6-chloropyrimidin-4-amine</strong> (357.2 mg; 1 .71 mmol; 1 .02 eq.), 4-[4- (4-fluoro-3-trifluoromethyl-phenyl)-1 -methyl-1 h-imidazol-2-yl]-piperidine (550.00 mg; 1 .68 mmol; 1.0 eq.), potassium carbonate (464.4 mg; 3.36 mmol; 2.0 eq.) in DMSO (6.0 ml) was stirred at 60 C overnight. The reaction mixture was poured into water. The precipitate was filtered, washed with water and dried under vacuum to afford the title compound in 86% yield. LC-MS: (M+1 =499, obsd. = 499).
 

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