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CAS No. : | 1082040-63-8 |
Formula : | C6H4IN3 |
M.W : | 245.02 |
SMILES Code : | IC1=NNC2=C1C=CN=C2 |
MDL No. : | MFCD11845480 |
Boiling Point : | No data available |
InChI Key : | BFJMHTOBRRZELQ-UHFFFAOYSA-N |
Pubchem ID : | 53399429 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
68% | With potassium carbonate; In N,N-dimethyl-formamide; at 20.0℃; for 2.0h; | To a solution of <strong>[1082040-63-8]3-iodo-1H-pyrazolo[3,4-c]pyridine</strong> (6.0 g, 24.5 mmol, 1.0 eq.) and K2C03 (4.0 g, 29.4 mmol, 1.2 eq.) in DMF (40 mL) was added tert-butyl 2-bromoacetate (4.78 g, 24.5 mmol, 1.0 eq.). The resulting mixture was stirred at r.t. for 2 h, then poured into water (200 mL), extracted with EtOAc (200 mL x 3). The combined organic layers were dried and concentrated under vacuum. The residue was purified by column chromatography (PE/EtOAc=3 :1) to providetert-butyl 2-(3 -iodo- 1 H-pyrazolo[3 ,4-c]pyridin- 1 -yl)acetate as a yellow oil (6.0 g, 68.0%). |
68% | With potassium carbonate; In N,N-dimethyl-formamide; at 20.0℃; for 2.0h; | To a solution of <strong>[1082040-63-8]3-iodo-1H-pyrazolo[3,4-c]pyridine</strong> (6.0 g, 24.5 mmol, 1.0 eq.) and K2C03 (4.0 g, 29.4 mmol, 1.2 eq.) in DMF (40 mL) was added tert-butyl 2- bromoacetate (4.78 g, 24.5 mmol, 1.0 eq.). The resulting mixture was stirred at rt for 2 h, poured into water (200 mL), and extracted with EtOAc (200 mL x 3). The combined organic layers were dried and concentrated. The residue was purified by column chromatography (PE/EtOAc=3:1) to PROVIDE tert-butyl 2-(3-iodo-1H-pyrazolo[3,4- c]pyridin-1-yl)acetate as a yellow oil (6.0 g, 68.0% yield). |
68% | With potassium carbonate; In N,N-dimethyl-formamide; at 20.0℃; for 2.0h; | To a solution of 3-iodo-lH-pyrazolo[3,4-c]pyridine (6.0 g, 24.5 mmol, 1.0 eq.) and K2C03 (4.0 g, 29.4 mmol, 1.2 eq.) in DMF (40 mL) was added tert-butyl 2-bromoacetate (4.78 g, 24.5 mmol, 1.0 eq.). The resulting mixture was stirred at r.t. for 2 h, then poured into water (200 mL), extracted with EtOAc (200 mL x 3). The combined organic layers were dried and concentrated under vacuum. The residue was purified by column chromatography (PE/EtOAc=3: l) to provide tert-butyl 2-(3-iodo-lH-pyrazolo[3,4- c]pyridin-l-yl)acetate as a yellow oil (6.0 g, 68.0% yield). |
With potassium carbonate; In acetonitrile; at 20.0℃; for 2.0h;Reflux; | To a suspension of 3-iodo-1 H-pyrazolo[3,4-c]pyridine (6.24 g, 22.9 mmol) and potassium carbonate (7.29 g, 52.7 mmol) in acetonitrile (50 mL) was added tert-butyl bromoacetate (4.06 mL, 27.5 mmol) dropwise at RT and the resulting mixture was heated to reflux for 2 h. The mixture was cooled to RT and filtered, the solid was washed with CH3CN and the filtrate was concentrated under vacuum. The residual oil was purified by flash column chromatography on silica gel (gradient EtOAc/c-hexane 1 :4, then 1 :2, then 1 :1). MS (LC/MS): 360.0 [M+H]+; tR (HPLC conditions k): 2.93 min. | |
With potassium carbonate; In acetonitrile; for 2.0h;Reflux; | B. Tert-butyl 2-(3-iodo-I H-pyrazolo[3,4-c]pyridi n-I -yI)acetateTo a suspension of 3-iodo-1 H-pyrazolo[3,4-c]pyridine (6.24 g, 22.9 mmol) and potassium carbonate (7.29 g, 52.7 mmol) in CH3CN (50 mL) was added tert-butyl bromoacetate (4.06 mL, 27.5 mmol) dropwise at RT and the resulting mixture was heated to reflux for 2 h. The mixture was cooled to RT and filtered, the solid was washed with CH3CN and the filtrate was concentrated under vacuum. The residual oil was purified by flash column chromatography on silica gel (EtOAcc-hexane 1:4, to 1:2, to 1:1) to give the title compound. MS (LCMS): 360.0 [M+H]+; tR (HPLC conditions d): 2.93 mm. | |
With potassium carbonate; In acetonitrile; for 2.0h;Reflux; | B. Tert-butyl 2-(3-iodo-I H-pyrazolo[3,4-c]pyridi n-I -yI)acetateTo a suspension of 3-iodo-IH-pyrazolo[3,4-c]pyridine (6.24 g, 22.9 mmol) and potassium carbonate (7.29 g, 52.7 mmol) in CH3CN (50 mL) was added dropwise at RT tert-butyl 2- bromoacetate (4.06 mL, 27.5 mmol). The resulting mixture was refluxed for 2 h. The mixture was cooled to RT and filtered, the solid was washed with CH3CN and the filtrate was concentrated and purified by flash column chromatography on silica gel (c-hexane/EtOAc 4:1, then 2:1, then 1:1) to afford the title compound. MS (LC/MS): 360.0 [M+H]+; tR (HPLC conditions d): 2.93 mm. | |
With potassium carbonate; In acetonitrile; for 2.0h;Reflux; | To a suspension of 3-iodo-1 H-pyrazolo[3,4-c]pyridine (6.24 g, 22.9 mmol) and potassium carbonate (7.29 g, 52.7 mmol) in CH3CN (50 mL) was added tert-butyl bromoacetate (4.06 mL, 27.5 mmol) dropwise at RT and the resulting mixture was heated to reflux for 2 h. The mixture was cooled to RT and filtered, the solid was washed with CH3CN and the filtrate was concentrated under vacuum. The residual oil was purified by flash column chromatography on silica gel (EtOAc/c-hexane 1 :4, to 1 :2, to 1 :1 ) to give the title compound. MS (LC/MS): 360.0 [M+H]+; tR (HPLC conditions d): 2.93 min. | |
With potassium carbonate; In acetonitrile; for 2.0h;Reflux; | To a suspension of <strong>[1082040-63-8]3-iodo-1H-pyrazolo[3,4-c]pyridine</strong> (6.24 g, 22.9 mmol) and potassium carbonate (7.29 g, 52.7 mmol) in CH3CN (50 mL) was added tert-butyl 2-bromoacetate (4.06 mL, 27.5 mmol) dropwise. The resulting mixture was heated to reflux for 2 h, cooled to RT and filtered, the solid was washed with CH3CN and the filtrate was concentrated and the product was purified by flash column chromatography on silica gel (c-hexaneEtOAc 4:1 to 1:1). MS (LCMS): 360.0 [M+H]+; tR (H PLC conditions d): 2.93 mm. | |
With potassium carbonate; In acetonitrile; for 2.0h;Reflux; | To a suspension of <strong>[1082040-63-8]3-iodo-1H-pyrazolo[3,4-c]pyridine</strong> (6.24 g, 22.9 mmol) and potassium carbonate (7.29 g, 52.7 mmol) in CH3CN (50 mL) was added tert-butyl bromoacetate (4.06 mL, 27.5 mmol) dropwise at RT and the resulting mixture was heated to reflux for 2 h. The mixture was cooled to RT and filtered, the solid was washed with CH3CN and the filtrate was concentrated under vacuum. The residual oil was purified by flash column chromatography on silica gel (EtOAcc-hexane 1:4, to 1:2, to 1:1) to give the title compound. MS (LCMS): 360.0 [M+H]+; tR (HPLC conditions b): 2.93 mm. | |
With potassium carbonate; In acetonitrile; for 2.0h;Reflux; | To a suspension of 3-iodo-1 H-pyrazolo[3,4-c]pyridine (6.24 g, 22.9 mmol) and potassium carbonate (7.29 g, 52.7 mmol) in CH3CN (50 mL) was added dropwise at RT, tert-butyl 2-bromoacetate (4.06 mL, 27.5 mmol). The reaction mixture was refluxed for 2 h, cooled to RT and filtered. The solid was washed with CH3CN, the filtrate was concentrated and the product purified by flash column chromatography on silica gel (EtOAcc-hexane 1:4, then 1:2, then 1:1). MS (LCMS): 360.0 [M+H]+; tR (HPLC conditions d): 2.93 mm. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20.0℃; | A suspension of 1H-pyrazolo[3,4-c]pyridine (300 mg, 2.52 mmol, 1.00 equiv), KOH (500 mg,8.91 mmol, 3.50 equiv), and diiodane (1.28 g, 5.04 mmol, 2.00 equiv) in DMF (10 mL) was stirredovernight at room temperature. The reaction was quenched by water, extracted with ethyl acetate,dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified bya silica gel column with ethyl acetate/petroleum ether (1:1) to give the title compound (577 mg,84%) as a yellow solid. LC-MS (ES, mlz): 246 [M+H]. |
73% | With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20.0℃; for 3.0h; | To a solution of 1H-pyrazolo[3,4-c]pyridine (4.0 g, 33.6 mmol, 1.0 eq.) in DMF(40 mL) were added K2C03 (9.3 g, 100.8 mmol, 3.0 eq.), ?2 (7.9 g, 33.6 mmol, 1.0 eq.). Theresulting mixture was stirred at r.t. for 3 hr, then diluted by H20 and filtered. The collectedsolid was dried to give 3-iodo-1H-pyrazolo[3,4-c]pyridine (6.0 g, 73.0 %). |
73% | With iodine; potassium carbonate; In N,N-dimethyl-formamide; at 20.0℃; for 3.0h; | To a solution of 1H-pyrazolo[3,4-c]pyridine (4.0 g, 33.6 mmol, 1.0 eq.) in DMF (40 mL) were added K2C03 (9.3 g, 100.8 mmol, 3.0 eq.) and ?2 (7.9 g, 33.6 mmol, 1.0 eq.). The resulting mixture was stirred at rt for 3 h, then diluted by H20 and filtered. The solid was collected and dried to give 3-iodo-1H-pyrazolo[3,4-c]pyridine (6.0 g, 73.0 % yield). |
73% | With iodine; potassium carbonate; In N,N-dimethyl-formamide; at 20.0℃; for 3.0h; | To a solution of lH-pyrazolo[3,4-c]pyridine (4.0 g, 33.6 mmol, 1.0 eq.) in DMF (40 mL) were added K2C03 (9.3 g, 100.8 mmol, 3.0 eq.), I2 (7.9 g, 33.6 mmol, 1.0 eq.). The resulting mixture was stirred at r.t. for 3 hr, then diluted by H20 and filtered. The collected solid was dried to give 3-iodo-lH- pyrazolo[3,4-c]pyridine (6.0 g, 73.0 % yield). |
With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20.0℃; for 16.0h; | To a solution of 1 H-pyrazolo[3,4-c]pyridine [271-47-6 ] (4.00 g, 33.6 mmol) in DMF (50 mL) were added iodine (12.8 g, 50.4 mmol) and potassium hydroxide (4.70 g, 84.0 mmol). The reaction mixture was stirred at RT for 16 h. The mixture was diluted with 10% sodium thiosulfate and water, then extracted (3x) with EtOAc. The combined organic extracts were washed with brine, then dried (Phase separator) and concentrated under vacuum. MS (LC/MS): 246.0 [M+H]+; tR (HPLC conditions k): 0.48 min. | |
With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20.0℃; for 16.0h; | A. 3-Iodo-I H-pyrazolo[3,4-c]pyridineTo a solution of 1 H-pyrazolo[3,4-c]pyridine [27 1-47-6 1(4.00 g, 33.6 mmol) in DMF (50 mL) were added iodine (12.8 g, 50.4 mmol) and potassium hydroxide (4.70 g, 84.0 mmol). The reaction mixture was stirred at RT for 16 h. The mixture was diluted with 10% sodium thiosulfate and water, then extracted (3x) with EtOAc. The combined organic extracts were washed with brine, dried (Phase separator) and concentrated under vacuum. MS (LCMS): 246.0 [M+H]+; tR (HPLC conditions d): 0.48 mm. | |
With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20.0℃; for 16.0h; | A. 3-lodo-1 H-pyrazolo[3,4-c]pyridineTo a solution of IH-pyrazolo[3,4-c]pyridine [271-47-6 ] (4.00 g, 33.6 mmol) in DMF (50 mL) were added iodine (12.8 g, 50.4 mmol) and potassium hydroxide (4.70 g, 84.0 mmol). The reaction mixture was stirred at RT for 16 h. The mixture was diluted with 10% sodium thiosulfate and water, then extracted (3x) with EtOAc. The combined organic extracts were washed with brine, dried (phase separator) and concentrated. MS (LC/MS): 246.0 [M+H]+; tR (H PLC conditions d): 0.48 mm. | |
With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20.0℃; for 16.0h; | To a solution of 1 H-pyrazolo[3,4-c]pyridine [271-47-6 ] (4.00 g, 33.6 mmol) in DMF (50 mL) were added iodine (12.8 g, 50.4 mmol) and potassium hydroxide (4.70 g, 84.0 mmol). The reaction mixture was stirred at RT for 16 h. The mixture was diluted with 10% sodium thiosulfate and water, then extracted (3x) with EtOAc. The combined organic extracts were washed with brine, dried (Phase separator) and concentrated under vacuum. MS (LC/MS): 246.0 [M+H]+; tR (HPLC conditions d): 0.48 min. | |
With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20.0℃; for 16.0h; | To a solution of 1H-pyrazolo[3,4-c]pyridine [271-47-6] (4.00 g, 33.6 mmol) in DMF (50 mL) were added iodine (12.8 g, 50.4 mmol) and potassium hydroxide (4.70 g, 84.0 mmol). The reaction mixture was stirred at RT for 16 h. The mixture was diluted with 10% sodium thiosulfate and water and extracted with EtOAc (3x). The combined organic extracts were washed with brine, dried (phase separator) and concentrated to afford the title compound. MS (LCMS): 246.0 [M+H]+; tR (H PLC conditions d): 0.48 mm. | |
With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20.0℃; for 16.0h;Inert atmosphere; | To a solution of 1H-pyrazolo[3,4-c]pyridine [271-47-6 1(4.00 g, 33.6 mmol) in DMF (50 mL) were added iodine (12.8 g, 50.4 mmol) and potassium hydroxide (4.70 g, 84.0 mmol). The reaction mixture was stirred at RT for 16 h. The mixture was diluted with 10% sodium thiosulfate and water, then extracted (3x) with EtOAc. The combined organic extracts were washed with brine, dried (Phase separator) and concentrated under vacuum. MS (LCMS):246.0 [M+H]+; tR (H PLC conditions b): 0.48 mm. | |
With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20.0℃; for 16.0h; | To a solution of 1H-pyrazolo[3,4-c]pyridine [271-47-61(4.00 g, 33.6 mmol) in DMF (50 mL) were added iodine (12.8 g, 50.4 mmol) and potassium hydroxide (4.70 g, 84.0 mmol). The reaction mixture was stirred at RT for 16 h. The mixture was diluted with 10% sodium thiosulfate and water, then extracted with EtOAc (3x). The combined organic extracts were washed with brine, dried (phase separator) and concentrated. MS (LCMS): 246.0 [M+H]+; tR (H PLC conditions d):0.48 mm. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | With copper(l) iodide; In dimethyl sulfoxide; at 150.0℃;Inert atmosphere; | Step 4: synthesis of 3-methanesulfonyl- 1 H-pyrazolo [3 ,4-c]pyridine To a solution of <strong>[1082040-63-8]3-iodo-1H-pyrazolo[3,4-c]pyridine</strong> 3 (9.5 g, 38.8 mmol) in DMSO (20 mL) was added aq. MeSNa (wt. 20%, 40 mL, 116 mmol), followed by CuT (270 mg, 1.94 mmol). The mixture was degas sed and refilled with nitrogen. The reaction was heated at 150 C overnight. After cooled to RT, the volatiles were removed and the residue was purified by column (PE/EtOAc=2/1 to 1/1) to give 3-(methylthio)-1H-pyrazolo[3,4-c]pyridine (3.2 g, yield: 50%) asa yellow solid. MS obsd. (ESIj [(M+H)?i 166.0.To a solution of 3-(methylthio)-1H-pyrazolo[3,4-c]pyridine (10 g, 60.6 mmol) in DMF (100 mL) was added oxone (37 g, 121.2 mmol.) in portions. The reaction mixture was stirred at RT. After the reaction completed, water (100 mL) was added. The reaction was quenched carefully by addition of Na2503 and Na2CO3. The solid was filtered off and washed with MeOH (300 mL).The filtrate was concentrated under vacuum and the residue was purified by chromatography on silica gel column (DCM/MeOH=20/1) to give 3-(methylsulfonyl)-1H-pyrazolo[3,4-c]pyridine (10.7g, yield: 90%) as a yellow solid. MS obsd. (ESIj [(M+H)?i 198.0. |
50% | With copper(l) iodide; In water; dimethyl sulfoxide; at 150.0℃;Inert atmosphere; | Step 4: synthesis of 3-methanesulfonyl-1H-pyrazolo[3,4-c]pyridine To a solution of <strong>[1082040-63-8]3-iodo-1H-pyrazolo[3,4-c]pyridine</strong> 3 (9.5 g, 38.8 mmol) in DMSO (20 mL) was added aq. MeSNa (wt. 20%, 40 mL, 116 mmol), followed by CuI (270 mg, 1.94 mmol). The mixture was degassed and refilled with nitrogen. The reaction was heated at 150 C. overnight. After cooled to RT, the volatiles were removed and the residue was purified by column (PE/EtOAc=2/1 to 1/1) to give 3-(methylthio)-1H-pyrazolo[3,4-c]pyridine (3.2 g, yield: 50%) as a yellow solid. MS obsd. (ESI+) [(M+H)+] 166.0. To a solution of 3-(methylthio)-1H-pyrazolo[3,4-c]pyridine (10 g, 60.6 mmol) in DMF (100 mL) was added oxone (37 g, 121.2 mmol.) in portions. The reaction mixture was stirred at RT. After the reaction completed, water (100 mL) was added. The reaction was quenched carefully by addition of Na2SO3 and Na2CO3. The solid was filtered off and washed with MeOH (300 mL). The filtrate was concentrated under vacuum and the residue was purified by chromatography on silica gel column (DCM/MeOH=20/1) to give 3-(methylsulfonyl)-1H-pyrazolo[3,4-c]pyridine (10.7 g, yield: 90%) as a yellow solid. MS obsd. (ESI+) [(M+H)+] 198.0. |
50% | With copper(l) iodide; In water; dimethyl sulfoxide; at 150.0℃;Inert atmosphere; | To a solution of <strong>[1082040-63-8]3-iodo-1H-pyrazolo[3,4-c]pyridine</strong> 3 (9.5 g, 38.8 mmol) in DMSO (20 mL) was added aq. MeSNa (wt. 20%, 40 mL, 116 mmol), followed by CuI (270 mg, 1.94 mmol). The mixture was degassed and refilled with nitrogen. The reaction was heated at 150 C. overnight. After cooled to RT, the volatiles were removed and the residue was purified by column (PE/EtOAc=2/1 to 1/1) to give 3-(methylthio)-1H-pyrazolo[3,4-c]pyridine (3.2 g, yield: 50%) as a yellow solid. MS obsd. (ESI+) [(M+H)+] 166.0. To a solution of 3-(methylthio)-1H-pyrazolo[3,4-c]pyridine (10 g, 60.6 mmol) in DMF (100 mL) was added oxone (37 g, 121.2 mmol.) in portions. The reaction mixture was stirred at RT. After the reaction completed, water (100 mL) was added. The reaction was quenched carefully by addition of Na2SO3 and Na2CO3. The solid was filtered off and washed with MeOH (300 mL). The filtrate was concentrated under vacuum and the residue was purified by chromatography on silica gel column (DCM/MeOH=20/1) to give 3-(methylsulfonyl)-1H-pyrazolo[3,4-c]pyridine (10.7 g, yield: 90%) as a yellow solid. MS obsd. (ESI+) [(M+H)+] 198.0. |
Tags: 1082040-63-8 synthesis path| 1082040-63-8 SDS| 1082040-63-8 COA| 1082040-63-8 purity| 1082040-63-8 application| 1082040-63-8 NMR| 1082040-63-8 COA| 1082040-63-8 structure
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P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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