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Chemical Structure| 107713-64-4 Chemical Structure| 107713-64-4

Structure of 107713-64-4

Chemical Structure| 107713-64-4

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Product Details of [ 107713-64-4 ]

CAS No. :107713-64-4
Formula : C9H4F6O2
M.W : 258.12
SMILES Code : O=C(C1=CC=C(OC(F)(F)F)C=C1)C(F)(F)F

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Application In Synthesis of [ 107713-64-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 107713-64-4 ]

[ 107713-64-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 107713-64-4 ]
  • [ 666746-27-6 ]
  • [ 849370-49-6 ]
YieldReaction ConditionsOperation in experiment
Step 3; Preparation of t-butyl 4-[2,2,2-trifluoro-1-hydroxy-1-(4-trifluoromethoxyphenyl)-ethyl]-2-methylcarbanilate; Under nitrogen atmosphere, to 130 ml of a t-butyl methyl ether solution containing 10.0 g of t-butyl 4-iodo-2-methylcarbanilate was added dropwise 41.8 ml of n-butyl lithium (1.58M hexane solution) at -60C under stirring, and after completion of the dropwise addition, the temperature of the mixture was raised to 0C, and the mixture was stirred for further 30 minutes. Then, the reaction mixture was cooled to -78C, 7.75 g of 2,2,2-trifluoro-4'-trifluoromethoxyacetophenone was added to the mixture, the temperature of the mixture was gradually raised to 0C, and stirring of the mixture was continued at the same temperature for further 30 minutes. After completion of the reaction, the reaction mixture was poured into 300 ml of a saturated aqueous ammonium chloride solution, the organic layer was collected by separation, and the aqueous layer was extracted with 100 ml of ethyl acetate. The organic layers were combined, dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue was purified by silica gel chromatography eluting with ethyl acetate-hexane (1: 19 to 1: 4) to obtain 9.0 g of the objective product as colorless oily substance. 1H NMR (CDCl3, Me4Si, 300MHz) δ 7.87 (d, J=8.5Hz, 1H), 7.50 (d, J=8.8Hz, 2H), 7.1-7.35 (m, 4H), 6.31 (bs, 1H), 2.95 (bs, 1H), 2.23 (s, 3H), 1.52 (s, 9H).
 

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