Home Cart Sign in  
Chemical Structure| 107346-32-7 Chemical Structure| 107346-32-7

Structure of 107346-32-7

Chemical Structure| 107346-32-7

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 107346-32-7 ]

CAS No. :107346-32-7
Formula : C12H13BrN4O
M.W : 309.16
SMILES Code : O=C(C1=NN=C2C(Br)=CC=CC2=C1N)NCCC
MDL No. :MFCD09033205

Safety of [ 107346-32-7 ]

Application In Synthesis of [ 107346-32-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 107346-32-7 ]

[ 107346-32-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 107346-32-7 ]
  • [ 175883-62-2 ]
  • 4-amino-8-(4-methoxy-3-methyl-phenyl)-N-propyl-cinnoline-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% EXAMPLE 73 4-amino-8-(4-methoxy-3-methyl-phenyl)-N-propyl-cinnoline-3-carboxamide Using method A, 4-amino-8-bromo-N-propyl-cinnoline-3-carboxamide (125 mg, 0.40 mmol) and <strong>[175883-62-2](4-methoxy-3-methylphenyl)boronic acid</strong> (133 mg, 0.80 mmol) were reacted to afford the title compound (105 mg, 75% yield) as a white solid. 1H NMR (300 MHz, CDCl3) delta 8.59 (bs, 1H), 7.76-7.82 (m, 2H), 7.67-7.72 (m, 1H), 7.53 (dd, J=8.2, 2.2 Hz, 1H), 7.46 (m, 1H), 6.96 (d, J=8.2, 1H), 3.89 (s, 3H), 3.46 (apparent q, J=6.7 Hz, 2H), 2.30 (s, 3H), 1.67 (apparent sextet, J=7.2 Hz, 2H), 1.00 (t, J=7.4 Hz, 3H). MS APCI, m/z=351 (M+H) HPLC 1.88 min.
  • 2
  • [ 107346-32-7 ]
  • [ 628692-15-9 ]
  • 4-amino-8-(2-methoxy-pyrimidin-5-yl)-N-propyl-cinnoline-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
77% EXAMPLE 7 4-amino-8-(2-methoxypyrimidin-5-yl)-N-propyl-cinnoline-3-carboxamide Using method A, 4-amino-8-bromo-N-propyl-cinnoline-3-carboxamide (100 mg, 0.324 mmol) and <strong>[628692-15-9](2-methoxypyrimidin-5-yl)boronic acid</strong> (104 mg, 0.68 mmol) were reacted to afford the title compound (84 mg, 77percent yield) as a white solid. 1H NMR (300 MHz, DMSO-d6) delta 9.1-9.3 (m, 1.5H), 8.96 (s, 2H), 8.47 (dd, J=8.4, 1.0 Hz, 1H), 8.1-8.4 (bm, 0.5 H), 7.99 (dd, J=7.2, 1.0 Hz, 1H), 7.83 (dd, J=8.4, 7.2 Hz, 1H), 4.01 (s, 3H), 3.32 (apparent q, J=7.4 Hz, 2H), 1.60 (apparent sextet, J=7.2 Hz, 2H), 0.91 (t, J=7.4 Hz, 3H). MS APCI, m/z=339 (M+H) HPLC 1.75 min.
  • 3
  • [ 107346-32-7 ]
  • [ 365564-07-4 ]
  • 4-amino-8-(3,5-dimethoxy-phenyl)-N-propyl-cinnoline-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
93.9% EXAMPLE 21 4-amino-8-(3,5-dimethoxyphenyl)-N-propyl-cinnoline-3-carboxamide Using method A, 4-amino-8-bromo-N-propyl-cinnoline-3-carboxamide (100 mg, 0.33 mmol) and 2-(3,5-dimethoxyphenyl)-4,4,5,5-tetramethyl-(1,3,2)-dioxaborolane (256 mg, 0.97 mmol) were reacted to afford the title compound (110 mg, 93.9% yield) as an off-white solid. 1H NMR (300 MHz, CDCl3) delta 8.57 (br, 1H), 7.87 (d, J=8.2 Hz, 1H), 7.79 (dd, J=7.2 Hz, J'=1.3 Hz, 1H), 7.71 (t, J=7.7 Hz, 1H), 6.79 (d, 3H), 3.83 (s, 6H), 3.47 (q, J=6.7 Hz, 2H), 1.67 (m, J=7.3 Hz, 2H), 1.01 (t, J=7.4 Hz, 3H) MS APCI, m/z=367 (M+H) HPLC 1.98 min.
 

Historical Records

Technical Information

Categories