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Chemical Structure| 1073354-66-1 Chemical Structure| 1073354-66-1

Structure of 1073354-66-1

Chemical Structure| 1073354-66-1

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Product Details of [ 1073354-66-1 ]

CAS No. :1073354-66-1
Formula : C14H19BO3
M.W : 246.11
SMILES Code : CC1=C(C=CC(C=O)=C1)B1OC(C)(C)C(C)(C)O1
MDL No. :MFCD08669583
InChI Key :JUFVNKBJTLKQGA-UHFFFAOYSA-N
Pubchem ID :44119094

Safety of [ 1073354-66-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 1073354-66-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1073354-66-1 ]

[ 1073354-66-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 78775-11-8 ]
  • [ 73183-34-3 ]
  • [ 1073354-66-1 ]
  • 2
  • [ 1073354-66-1 ]
  • [ 1403257-80-6 ]
  • [ 1403258-22-9 ]
YieldReaction ConditionsOperation in experiment
69.28% With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 100℃; for 4h;Inert atmosphere; Step 1: Synthesis of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4'-formyl-2',4-dimethyl-[1,1'-biphenyl]-3-carboxamide To a stirred solution of <strong>[1403257-80-6]5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide</strong> (400 mg, 0.84 mmol) and 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (310 mg, 1.26 mmol) in dioxane (2 mL), aqueous 2M Na2CO3 solution (1.5 mL, 3.03 mmol) was added and solution was purged with argon for 15 min. Then Pd(PPh3)4 (97 mg, 0.08 mmol) was added and argon was purged again for 15 min. Reaction mass was heated at 100 C. for 4 h. On completion, reaction mixture was diluted with water and extracted with 10% MeOH/DCM (3 times). Combined organic layer was dried over sodium sulphate. Removal of the solvent under reduced pressure followed by column chromatographic purification afforded the desired compound (300 mg, 69.28%).
 

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