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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
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Structure of 1072-85-1
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
4.5
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CAS No. : | 1072-85-1 |
Formula : | C6H4BrF |
M.W : | 175.00 |
SMILES Code : | FC1=CC=CC=C1Br |
MDL No. : | MFCD00000282 |
InChI Key : | IPWBFGUBXWMIPR-UHFFFAOYSA-N |
Pubchem ID : | 61259 |
GHS Pictogram: |
![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H225-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Class: | 3 |
UN#: | 1993 |
Packing Group: | Ⅲ |
Num. heavy atoms | 8 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.0 |
Num. rotatable bonds | 0 |
Num. H-bond acceptors | 1.0 |
Num. H-bond donors | 0.0 |
Molar Refractivity | 34.1 |
TPSA ? Topological Polar Surface Area: Calculated from |
0.0 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
2.04 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
2.71 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
3.01 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
3.48 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
3.0 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
2.85 |
Log S (ESOL):? ESOL: Topological method implemented from |
-3.19 |
Solubility | 0.114 mg/ml ; 0.00065 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (Ali)? Ali: Topological method implemented from |
-2.36 |
Solubility | 0.758 mg/ml ; 0.00433 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-3.52 |
Solubility | 0.0522 mg/ml ; 0.000299 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
Low |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-5.44 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
2.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.33 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
5.2 %Chromat. | Stage #1: With sodium hexamethyldisilazane In tetrahydrofuran at 65℃; for 1 h; Stage #2: With hydrogenchloride; water In tetrahydrofuran |
Example 4; Reaction of haloarenes and 2-methylpropionitrile in the presence of various bases in THF. The reaction tubes of Mettler Toledo MiniBlock.(TM). were independently charged with the haloarenes (0.01 mol) identified below and a solution of 2-methylpropionitrile in THF (8.5 mL, 0.01 mol) which was prepared from the nitrile (14 g) and THF (160 mL). An equimolar amount of the base (0.01 mol) was independently added to each tube dropwise at ambient temperature. The reaction mixtures were heated to 65° C. over 1 hour, cooled to ambient temperature and quenched with 5percent HCl (6 mL). The organic phases were separated and the solvents were evaporated. The crude product mixtures were examined using gas chromatography (GC)/mass spectroscopy (MS) and proton nuclear magnetic resonance (1H-NMR).F. haloarene: 1-bromo-2-fluorobenzene; base: sodium hexamethyldisilazide (1M in THF); product: 2-(2-bromophenyl)-2-methylpropionitrile (5.2percent by GC/MS) and residual haloarene (76.8percent) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
64% | INTERMEDIATE PREPARATION 76-bromo-7-fluoro-1 /-/-indole-2,3-dione3-bromo-2-fluorobenzoic acidTo a solution of diisopropylamine (84.3 mL, 600 mmol) in THF (500 mL) at -30C was added n-BuLi (240 mL of a 2.5M solution, 600 mmol) dropwise. The resulting solution was stirred at -30C for 30 min. This mixture was added dropwise to a solution of 1-bromo-2- fluorobenzene (100 g, 571 .43 mmol) in THF (500 mL) at -78C. After the addition was complete, the resulting solution was stirred at -78C for 2 h and poured over crushed solid C02. After removal of the solvent in vacuo, the resulting residue was diluted with water and washed with diethyl ether (2 x 500 mL). The aqueous phase was acidified with 1 N HCI to pH 2. The precipitate was collected by filtration and dried to afford 3-bromo-2-fluorobenzoic acid (90 g, 64% yield) as a white solid. MS (m/z) 221.0 (M+H+). | |
55% | With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -75 - -10℃; for 3.5h; | Example 16 3-Bromo-2-fluorobenzoic acid To a stirred solution of 2,2,6,6-tetramethylpiperidine (31.1 g, 0.22 mol) in THF (200 mL) was added dropwise a solution of butyl lithium (0.22 mol) in hexane (146.7 mL) at -10 C. The mixture was stirred for 1.5 h at -10 C. and the fluoroarene (1-bromo-2-fluorobenzene) in THF (100 mL) was consecutively added to the solution at -75 C. The mixture was stirred for 2 h at -75 C., before being poured on excess of CO2 gas. Then the reaction mixture was warmed to room temperature and stirred over night. After evaporation of the solvent, the residue was dissolved in water (150 mL), washed with diethyl ether (2*50 mL), acidified (to pH 1) and the solid was filtered off and dried under vacuum to give 24.3 g of the title compound as a white solid (yield: 55%). |
55% | Example 16 3-Bromo-2-fluorobenzoic Acid To a stirred solution of 2,2,6,6-tetramethylpiperidine (31.1 g, 0.22 mol) in THF (200 mL) was added dropwise a solution of butyl lithium (0.22 mol) in hexane (146.7 mL) at -10 C. The mixture was stirred for 1.5 h at -10 C. and the fluoroarene (1-bromo-2-fluorobenzene) in THF (100 mL) was consecutively added to the solution at -75 C. The mixture was stirred for 2 h at -75 C., before being poured on excess of CO2 gas. Then the reaction mixture was warmed to room temperature and stirred over night. After evaporation of the solvent, the residue was dissolved in water (150 mL), washed with diethyl ether (2*50 mL), acidified (to pH 1) and the solid was filtered off and dried under vacuum to give 24.3 g of the title compound as a white solid (yield: 55%). |
55% | Example 19 3-Bromo-2-fluorobenzoic Acid To a stirred solution of 2,2,6,6-tetramethylpiperidine (31.1 g, 0.22 mol) in THF (200 mL) was added dropwise a solution of butyl lithium (0.22 mol) in hexane (146.7 mL) at -10 C. The mixture was stirred for 1.5 h at -10 C. and the fluoroarene (1-bromo-2-fluorobenzene) in THF (100 mL) was consecutively added to the solution at -75 C. The mixture was stirred for 2 h at -75 C. and an excess of freshly CO2 gas bubbled into the reaction mixture. Then the reaction mixture was warmed to room temperature and stirred over night. After evaporation of the solvent, the residue was dissolved in water (150 mL), washed with diethyl ether (2*50 mL), acidified (to pH 1) and the solid was filtered off, dried under vacuum to give 24.3 g of the title compound as a white solid (yield: 55%). | |
55% | Example 16 3-Bromo-2-fhiorobenzoic acidTo a stirred solution of 2,2,6,6-tetramethylpiperidine (31.1 g, 0.22 mol) in THF (200 mL) was added dropwise a solution of butyl lithium (0.22 mol) in hexane (146.7 mL) at -10 0C. The mixture was stirred for 1.5 h at -10 0C and the fluoroarene (l-bromo-2-fluorobenzene) in THF (100 mL) was consecutively added to the solution at -75 0C. The mixture was stirred for 2 h at -75 0C, before being poured on excess of CO2 gas. Then the reaction mixture was warmed to room temperature and stirred over night. After evaporation of the solvent, the residue was dissolved in water (150 mL), washed with diethyl ether (2 x 50 mL), acidified (to pH 1) and the solid was filtered off and dried under vacuum to give 24.3 g of the title compound as a white solid (yield: 55%). | |
20.78% | With lithium diisopropyl amide; In tetrahydrofuran; at -78℃; for 1h; | Carbon dioxide was purged for 15 min through a stirred solution of 1-bromo-2-fluorobenzene (5.0g, 28.57mmol, 1.0eq) in tetrahydrofuran (70mL) followed by addition of lithium diisopropylamide (2M) (42.8mL, 85.71mmol, 3.0eq) at -78C. The reaction mixture was stirred at -78C for 1h. After completion of reaction, reaction mixture was transferred to ice cold water and product was extracted with ethyl acetate. Organic layer was combined, washed with brine solution, dried over sodium sulfate and concentrated under reduced pressure to obtain crude material. This was further purified by column chromatography eluting with 7% ethyl acetate in hexane to obtain 23.1. (1.3g, Yield: 20.78%). MS (ES): m/z 218.94 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57% | With lithium; diisopropylamine; In tetrahydrofuran; water; | Intermediate 38: 3-Bromo-2-fluorobenzoic acid Tetrahydrofuran (60 ml) was added to diisopropylamine (9.6 ml, 68 mmol) in an argon atmosphere. n-Butyllithium (hexane solution, 1.5 M, 38 ml, 57 mmol) was added dropwise thereto at -10C, and the mixture was stirred for one hr. Separately, 55 ml of tetrahydrofuran was added to 1-bromo-2-fluorobenzene (10 g, 57 mmol) to prepare a solution which was then added dropwise to the lithium reagent solution at -78C. The mixture was stirred for 2 hr and was then stirred for additional 30 min while blowing carbon dioxide thereinto. The temperature of the reaction mixture was returned to room temperature, and the reaction mixture was concentrated under the reduced pressure. Water (200 ml) was added to the residue to prepare a solution, and the solution was washed twice with 100 ml of diethyl ether.The aqueous layer was adjusted to pH 1 by the addition of 1.0 M hydrochloric acid, was extracted twice with 300 ml of methylene chloride, was dried over anhydrous magnesium sulfate, and was concentrated under the reduced pressure to give the title compound (7.1 g, 57%). Physicochemical properties of intermediate 38 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | Step 1: 4-(2-Fluorobenzoyl)oxaneA solution of 1-bromo-2-fluorobenzene (10.1 g, 57.7 mmol) in tetrahydrofuran (50 mL) in a RB flask was cooled to -78 C in a dry ice and acetone bath and treated slowly via syringe with nBuLi, 2.5 M in hexanes (23.1 mL, 57.7 mmol), and the resulting amber solution stirred for 35 mm in bath. The mixture was treated with a solution <strong>[156353-01-4]N-methoxy-N-methyloxane-4-carboxamide</strong> (5.00 g, 28.9 mmol) in 10 mL of tetrahydrofuran via syringe to give a dark solution. After 2 h, the mixture was quenched with sat. aq. NH4C1 and extracted into ethyl acetate. The organics were washed with water and brine, and the volatiles were concentrated to give a dark-yellow oil. The material purified usingsilica gel column chromatography on an ISCO Companion (120 g silica gel column) and eluted with an EtOAc/hexane hexane gradient (10-40%). The fractions containing product were collected, and the volatiles were removed were collected, and the volatiles were removed to give 4-(2-fluorobenzoyl)oxane (4.50 g, 21.6 mmol, 75 %) as a light- amber oil. LCMS: Waters Acquity SDS. Column: BEH C18 2.1x50 mm 1.7u (1.6 mmgrad) 2-98 % B. Flow Rate = 0.8 mL/min. Solvent A: H20 -0.1 % TFA. Solvent B:Acetonitrile - 0.1 % TFA. LCMS: RT = 0.81 mm; (ES): mlz (M+H) = 209.1. HPLC:Chromolith ODS S5 4.6 x 50 mm (4 mm grad) 0-100% B. Flow Rate = 4 mL/min. Inj.Vol. = 10 uL. Wavelength = 220. Oven Temp. = 40 C. Solvent A: 10% MeOH - 90%H20 -0.1 % TFA. Solvent B: 90% MeOH - 10 % H20 - 0.1 % TFA. HPLC: RT = 1.797mm. | |
75% | With n-butyllithium; In tetrahydrofuran; hexane; for 0.583333h;Cooling with acetone-dry ice; | A solution of 1-bromo-2-fluorobenzene (10.1 g, 57.7 mmol) in tetrahydrofuran (50 mL) in a RB flask was cooled to -78 C. in a dry ice and acetone bath and treated slowly via syringe with nBuLi, 2.5 M in hexanes (23.1 mL, 57.7 mmol), and the resulting amber solution stirred for 35 min in bath. The mixture was treated with a solution <strong>[156353-01-4]N-methoxy-N-methyloxane-4-carboxamide</strong> (5.00 g, 28.9 mmol) in 10 mL of tetrahydrofuran via syringe to give a dark solution. After 2 h, the mixture was quenched with sat. aq. NH4Cl and extracted into ethyl acetate. The organics were washed with water and brine, and the volatiles were concentrated to give a dark-yellow oil. The material purified using silica gel column chromatography on an ISCO Companion (120 g silica gel column) and eluted with an EtOAc/hexane hexane gradient (10-40%). The fractions containing product were collected, and the volatiles were removed were collected, and the volatiles were removed to give 4-(2-fluorobenzoyl)oxane (4.50 g, 21.6 mmol, 75%) as a light-amber oil. LCMS: Waters Acquity SDS. Column: BEH C18 2.1×50 mm 1.7 u (1.6 min grad) 2-98% B. Flow Rate=0.8 mL/min. Solvent A: H2O-0.1% TFA. Solvent B: Acetonitrile-0.1% TFA. LCMS: RT=0.81 min; (ES): m/z (M+H)+=209.1. HPLC: Chromolith ODS S5 4.6×50 mm (4 min grad) 0-100% B. Flow Rate=4 mL/min. Inj. Vol.=10 uL. Wavelength=220. Oven Temp.=40 C. Solvent A: 10% MeOH -90% H2O-0.1% TFA. Solvent B: 90% MeOH -10% H2O-0.1% TFA. HPLC: RT=1.797 min. |
48% | 1-Bromo-2-fluorobenzene (3.5 g, 20 mmol) was dissolved in dry tetrahydrofuran (40 mL), and cooled to -78C under the protection of nitrogen. A 2.4 mol/L n-hexane solution of n-BuLi (10 mL, 24 mmol) was added dropwise slowly. The reaction mixture was stirred at - 78C for additional 30 min, and then a tetrahydrofuran (10 mL) solution of <strong>[156353-01-4]N-methoxy-N-methyltetrahydro-2H-pyran-4-carboxamide</strong> (4.16 g, 24 mmol) was added dropwise. The reaction mixture was slowly warmed to room temperature, and stirred overnight. An ammonium chloride aqueous solution was added to quench the reaction. The reaction mixture was poured into water, and extracted with ethyl acetate. The organic phase was separated, washed with a saturated saline solution, and dried. The solvent was removed under vacuum to obtain a crude product. The crude product was purified by column chromatography to obtain the product (2 g, 48%). 1H NMR (400 MHz, CDCl3): delta 7.76-7.80 (m, 1H), 7.49-7.54 (m, 1H), 7.22-7.27 (m, 1H), 7.10-7.15 (m, 1H), 4.00-4.05 (m, 2H), 3.49-3.55 (m, 2H), 3.32-3.40 (m, 1H), 1.73-1.86 (m, 4H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With caesium carbonate; In N,N-dimethyl-formamide; at 150℃; for 2h; | The preparation method of the compound of formula M1 is as follows:2.5 g (15.0 mmol) of carbazole, 10.7 g (60.0 mmol) of 1-bromo-2-fluorobenzene, and 8.5 g (20.0 mmol) of cesium carbonate were sequentially added to a 250 mL two-necked flask.And 130 mL of N,N-dimethylformamide,The mixture was heated to 150 C with stirring for 24 hours.After the reaction is complete, the system is cooled to room temperature.Pour into water and filter by vacuum.And wash the filter residue with a large amount of water, and filter the residue with dichloromethane:The petroleum ether = 1:4 (volume ratio) eluent was separated and purified on a silica gel column to obtain 4.4 g of M1.The yield was 92.0%. |
87% | With caesium carbonate; In N,N-dimethyl-formamide; at 150℃; for 24h; | General procedure: A mixture of a fluorinated aryl halide (2.0 mmol), a carbazole (0.5 mmol), and a base (2.0 mmol) in solvent (2 mL) was allowed to react under air atmosphere. The reaction mixture was heated to the specified temperature for 24 h. After reaction completion, the mixture was added to brine (15 mL) and extracted with CH2Cl2 (3 × 15 mL). The combined extract was concentrated under reduced pressure and the product was isolated by short chromatography on a silica gel (200-300 mesh) column. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 170℃; for 15h;Inert atmosphere; | To a three-necked flask, 3.00 g (9.03 mmol) of 9H-3,9?-bicarbazole, 1.90 g (10.8 mmol) of 1-bromo-2-fluorobenzene, 5.88 g (18.1 mmol) of cesium carbonate, And 18 mL of NMP were added, and the mixture was heated and stirred at 170 C. for 15 hours under an argon atmosphere. After cooling to room temperature (25 C.), water was added to the reaction mixture, and the solid was collected by filtration. The obtained solid was purified by silica gel column chromatography, and the obtained solid was suspended and washed with methanol to obtain an intermediate (2-A). The yield was 3.80 g, and the yield was 85%. |
Tags: 1072-85-1 synthesis path| 1072-85-1 SDS| 1072-85-1 COA| 1072-85-1 purity| 1072-85-1 application| 1072-85-1 NMR| 1072-85-1 COA| 1072-85-1 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
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Code | Phrase |
P201 | Obtain special instructions before use. |
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Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
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P313 | Get medical advice/attention. |
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P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
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P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
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P337 | If eye irritation persists: |
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P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
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P378 | |
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P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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