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Structure of 106973-37-9

Chemical Structure| 106973-37-9

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Product Details of [ 106973-37-9 ]

CAS No. :106973-37-9
Formula : C12H13NO4
M.W : 235.24
SMILES Code : O=C([C@H](COC1)N(CC2=CC=CC=C2)C1=O)O
MDL No. :MFCD09835535
InChI Key :LAHROJZLGLNLBT-JTQLQIEISA-N
Pubchem ID :13543372

Safety of [ 106973-37-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 106973-37-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 106973-37-9 ]

[ 106973-37-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 106973-37-9 ]
  • [ 101376-26-5 ]
YieldReaction ConditionsOperation in experiment
86% Intermediate 65(R)-(4-Benzylmorpholin-3-yl)methanol[0351][Chemical Formula 96]To a solution of intermediate 66 (12.6 g, 53.6 mmol) in tetrahydrofuran (200 mL) was added borane-tetrahydrofuran-complex (1.0 M, 348 mL). After stirring for 6 hours at room temperature, to the mixture was added methanol, and after heated to 80C, stirred for 2 hours. To the mixture were added saturated sodium bicarbonate water and ethyl acetate, and the aqueous layer was extracted with ethyl acetate. The organic layer was washed with water and brine, and then dried over sodium sulfate, and concentrated under reduced pressure. The obtained residue was purified with silica gel column (hexane/ethyl acetate = 90/10 to 10/90) to give the title compound (9.60 g, 46.0 mmol, 86%).MS (ESI+) 208 (IVT+l, 100%)
 

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