[ CAS No. 106848-38-8 ] 1-Benzyl-4-bromo-1H-imidazole

Cat. No.: A321928

2D 3D

Structure of 106848-38-8 * Storage: Sealed in dry,2-8°C

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Quality Control of [ 106848-38-8 ]

COA NMR CNMR HPLC LC-MS

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Specification

Alternatived Products of [ 106848-38-8 ]

Product Details of [ 106848-38-8 ]

CAS No. :	106848-38-8	MDL No. :	MFCD09033094
Formula :	C₁₀H₉BrN₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	SEDUHBKZBAORFI-UHFFFAOYSA-N
M.W :	237.10	Pubchem ID :	10354407
Synonyms :

Safety of [ 106848-38-8 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 106848-38-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 106848-38-8 ]
Downstream synthetic route of [ 106848-38-8 ]

[ 106848-38-8 ] Synthesis Path-Upstream 1~2

1
[ 2302-25-2 ]
[ 100-39-0 ]
[ 106848-38-8 ]
[ 132430-59-2 ]

Reference： [1] Angewandte Chemie - International Edition, 2013, vol. 52, # 38, p. 10035 - 10039[2] Angew. Chem., 2013, vol. 125, # 38, p. 10219 - 10223

2
[ 2302-25-2 ]
[ 100-44-7 ]
[ 106848-38-8 ]
[ 132430-59-2 ]

Reference： [1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 4044 - 4048
[2] Acta Chemica Scandinavica, 1990, vol. 44, # 10, p. 1050 - 1057
[3] Acta Chemica Scandinavica, 1990, vol. 44, # 10, p. 1050 - 1057

Yield	Reaction Conditions	Operation in experiment
	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at 25℃; for 2h;Inert atmosphere;	General procedure: PdCl2(dppf), PdCl2(tbpf) and (A.caPhos)PdCl2. A mixture of the halogenated heterocycle (0.66 mmol) in anhydrous THF (13.2 mL) was degassed by bubbling argon for few minutes. Then, PdCl2(dppf) (27.0 mg, 0.033 mmol, 5.0 mol%), TMEDA (0.130 g, 1.12 mmol, 1.7 equiv) and finally NaBH4 (42.4 mg, 1.12 mmol, 1.7 equiv) were introduced in sequence. The mixture was stirred at room temperature under argon for the proper time and then worked up as described above.

Yield	Reaction Conditions	Operation in experiment
	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at 25℃; for 2h;Inert atmosphere;	General procedure: PdCl2(dppf), PdCl2(tbpf) and (A.caPhos)PdCl2. A mixture of the halogenated heterocycle (0.66 mmol) in anhydrous THF (13.2 mL) was degassed by bubbling argon for few minutes. Then, PdCl2(dppf) (27.0 mg, 0.033 mmol, 5.0 mol%), TMEDA (0.130 g, 1.12 mmol, 1.7 equiv) and finally NaBH4 (42.4 mg, 1.12 mmol, 1.7 equiv) were introduced in sequence. The mixture was stirred at room temperature under argon for the proper time and then worked up as described above.

Yield	Reaction Conditions	Operation in experiment
65%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at 25℃; for 41h;Inert atmosphere;	General procedure: PdCl2(dppf), PdCl2(tbpf) and (A.caPhos)PdCl2. A mixture of the halogenated heterocycle (0.66 mmol) in anhydrous THF (13.2 mL) was degassed by bubbling argon for few minutes. Then, PdCl2(dppf) (27.0 mg, 0.033 mmol, 5.0 mol%), TMEDA (0.130 g, 1.12 mmol, 1.7 equiv) and finally NaBH4 (42.4 mg, 1.12 mmol, 1.7 equiv) were introduced in sequence. The mixture was stirred at room temperature under argon for the proper time and then worked up as described above.

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Technical Information

• Alkyl Halide Occurrence • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling

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[ 106848-38-8 ]

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[ 106848-38-8 ]

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[ CAS No. 106848-38-8 ] 1-Benzyl-4-bromo-1H-imidazole

Quality Control of [ 106848-38-8 ]

Related Doc. of [ 106848-38-8 ]

Product Details of [ 106848-38-8 ]

Safety of [ 106848-38-8 ]

Application In Synthesis of [ 106848-38-8 ]

[ 106848-38-8 ] Synthesis Path-Upstream 1~2

[ 106848-38-8 ] Synthesis Path-Downstream 1~16

Technical Information

Related Functional Groups of [ 106848-38-8 ]

Aryls

Bromides

Related Parent Nucleus of [ 106848-38-8 ]

Imidazoles

Precautionary Statements-General

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Environmental hazards

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Related Functional Groups of
[ 106848-38-8 ]

Related Parent Nucleus of
[ 106848-38-8 ]