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[ CAS No. 106730-54-5 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 106730-54-5
Chemical Structure| 106730-54-5
Structure of 106730-54-5 *Storage: {[proInfo.prStorage]}

Quality Control of [ 106730-54-5 ]

Related Doc. of [ 106730-54-5 ]

SDS

Product Details of [ 106730-54-5 ]

CAS No. :106730-54-5MDL No. :MFCD25541649
Formula : C14H10N4O Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :250.26Pubchem ID :4593
Synonyms :

1. Olprinone

Computed Properties of [ 106730-54-5 ]

TPSA : 70.2 H-Bond Acceptor Count : 3
XLogP3 : 1.5 H-Bond Donor Count : 1
SP3 : 0.07 Rotatable Bond Count : 1

Safety of [ 106730-54-5 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 106730-54-5 ]

  • Upstream synthesis route of [ 106730-54-5 ]
  • Downstream synthetic route of [ 106730-54-5 ]

[ 106730-54-5 ] Synthesis Path-Upstream   1~11

  • 1
  • [ 913835-63-9 ]
  • [ 84725-13-3 ]
  • [ 106730-54-5 ]
YieldReaction ConditionsOperation in experiment
71.7% With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In toluene at 90 - 100℃; for 24.00 h; Inert atmosphere 13.3 g of compound iii (0.062 mol), 12.1 g of compound vi (0.075 mol), 4.5 g of bis(triphenylphosphine)palladium(II) chloride (0.006 mol), 1.0 mol/L potassium carbonate solution 64ml in argon under the protection of added to 133ml toluene, heated to 90 ~ 100 , incubation reaction 24h. The reaction mixture was poured into 200 ml of purified water, extracted with 70 ml of ethyl acetate three times, twice with 100 ml of saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give a pale gray solid which was beaten with petroleum ether for 1 hour to give an off-white solid, i.e., Oprinon (compound ii), and weighed 11.2 g in a yield of 71.7percent.
Reference: [1] Patent: CN106349246, 2017, A. Location in patent: Paragraph 0023; 0028; 0029
  • 2
  • [ 106730-70-5 ]
  • [ 107-91-5 ]
  • [ 106730-54-5 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 6, p. 1556 - 1567
  • 3
  • [ 6188-23-4 ]
  • [ 106730-54-5 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 6, p. 1556 - 1567
[2] Patent: CN106349246, 2017, A
  • 4
  • [ 1072-97-5 ]
  • [ 106730-54-5 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 6, p. 1556 - 1567
  • 5
  • [ 36052-24-1 ]
  • [ 106730-54-5 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 6, p. 1556 - 1567
  • 6
  • [ 116355-16-9 ]
  • [ 106730-54-5 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 6, p. 1556 - 1567
  • 7
  • [ 116355-20-5 ]
  • [ 106730-54-5 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 6, p. 1556 - 1567
  • 8
  • [ 116355-08-9 ]
  • [ 106730-54-5 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 6, p. 1556 - 1567
  • 9
  • [ 136117-69-6 ]
  • [ 106730-54-5 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 6, p. 1556 - 1567
  • 10
  • [ 116355-21-6 ]
  • [ 106730-54-5 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 6, p. 1556 - 1567
  • 11
  • [ 4241-27-4 ]
  • [ 106730-54-5 ]
Reference: [1] Patent: CN106349246, 2017, A
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