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Chemical Structure| 106412-35-5 Chemical Structure| 106412-35-5

Structure of 106412-35-5

Chemical Structure| 106412-35-5

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Product Details of [ 106412-35-5 ]

CAS No. :106412-35-5
Formula : C13H15NO3
M.W : 233.26
SMILES Code : O=C(N1C(CCCC1)=O)OCC2=CC=CC=C2
MDL No. :MFCD09908205
InChI Key :LKGMGCSFOUSKCR-UHFFFAOYSA-N
Pubchem ID :11096497

Safety of [ 106412-35-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 106412-35-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 106412-35-5 ]

[ 106412-35-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 461-72-3 ]
  • [ 144-55-8 ]
  • [ 106412-35-5 ]
  • [ 28121-73-5 ]
  • [ 13625-39-3 ]
YieldReaction ConditionsOperation in experiment
With hydrogen; acetic acid;palladium-carbon; In ethanol; Step A Preparation of 1,3,8-triaza-spiro[4.5]decan-2,4-dione To a solution of 14.6 g (48.1 mmol) <strong>[28121-73-5]benzyl 2,4-dioxo-1,3,8-triaza-spiro[4.5]decan-8-carboxylate</strong> (prepared from N-(benzyloxycarbonyl)piperidone by the method from J. Med. Chem. 1995, 38, 3772) in 250 ml dry ethanol were added 500 mg 10% Pd/C, and the mixture was filled into an autoclave. After stirring at 60 C. and 10 atm of hydrogen for 3 h no starting hydantoin could be detected by TLC. A precipitate had been formed which was redissolved by addition of 100 ml acetic acid. The catalyst was removed by filtration and the solution was concentrated in vacuo. Aqueous sodium bicarbonate solution was added until the mixture became a clear solution, and the title compound precipitated in two crops upon concentration in vacuo. total yield: 8.1 g (99%), white powder, m.p. 303-304 C. (dec.)
 

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