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Chemical Structure| 106086-78-6 Chemical Structure| 106086-78-6

Structure of 2-bromomethyl benzothizaole
CAS No.: 106086-78-6

Chemical Structure| 106086-78-6

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Product Details of [ 106086-78-6 ]

CAS No. :106086-78-6
Formula : C8H6BrNS
M.W : 228.11
SMILES Code : BrCC1=NC2=C(S1)C=CC=C2
MDL No. :MFCD00461195
InChI Key :WFLCAOGKZQTOIG-UHFFFAOYSA-N
Pubchem ID :2776258

Safety of [ 106086-78-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H315-H318-H335
Precautionary Statements:P261-P280-P305+P351+P338
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 106086-78-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 106086-78-6 ]

[ 106086-78-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 106086-78-6 ]
  • [ 27328-68-3 ]
  • [ 26663-42-3 ]
  • [ 124955-54-0 ]
YieldReaction ConditionsOperation in experiment
In sodium hydroxide; water; EXAMPLE 1 1-[(benzothiazol-2-yl)methyl]-1H-indazole-3-acetic acid To a vigorously stirring solution of 1H-indazole-3-acetic acid (0.88 g) in water (100 ml) containing sodium hydroxide (0.60 g) was added 2-(bromomethyl)benzothiazole (1.25 g) and the resulting mixture heated at 80 C. for 2.5 hours. The reaction solution was cooled to room temperature and extracted with ether (2*25 ml). The aqueous layer was collected and acidified to a pH of about 4.0 with concentrated HCl, and then extracted with ethyl acetate (2*20 ml). The organic layers were combined, dried and evaporated to a yellow solid (yield: 0.67 g), which was crystallized from benzene (m.p. 164-165 C.). Substituting a molar equivalent of <strong>[27328-68-3]5-chloro-1H-indazole-3-acetic acid</strong> for 1H-indazole-3-acetic acid, the same method was employed to prepare: 1-(benzothiazol-2-yl)methyl-<strong>[27328-68-3]5-chloro-1H-indazole-3-acetic acid</strong> (m.p. 213 C.).
 

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