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Chemical Structure| 106018-85-3 Chemical Structure| 106018-85-3

Structure of 106018-85-3

Chemical Structure| 106018-85-3

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Product Details of [ 106018-85-3 ]

CAS No. :106018-85-3
Formula : C5H13ClO2SSi
M.W : 200.76
SMILES Code : C[Si](CCS(=O)(Cl)=O)(C)C
MDL No. :MFCD09265153

Safety of [ 106018-85-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H315-H319-H335
Precautionary Statements:P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 106018-85-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 106018-85-3 ]

[ 106018-85-3 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 52562-19-3 ]
  • [ 106018-85-3 ]
  • N-(2-(prop-1-en-2-yl)phenyl)-2-(trimethylsilyl)ethane-1-sulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
97% With pyridine; In dichloromethane; at 20℃; for 24h; General procedure: The aniline (0.5 g, 3.75 mmol, 1 equiv) was dissolved in dry CH2Cl2 (7.5 mL, 0.5 M), and thesolution was treated with sulfonyl chloride (0.79 g, 4.13 mmol, 1.1 equiv) and pyridine (0.91mL, 11.3 mmol, 3 equiv). The mixture was stirred at room temperature for 24 h, diluted withH2O (25 mL) and extracted with CH2Cl2 (3 x 25 mL). The combined organic layers were washedwith 1M HCl, brine, dried over Na2SO4, and concentrated in vacuo. Flash chromatography of theresulting crude mixture on SiO2 (0-30% EtOAc in hexanes gradient) afforded the sulfonamidesin good yields. Substrate 1b was synthesized according to the above procedure using <strong>[52562-19-3]2-isopropenylaniline</strong> and 2-(trimethylsilyl)ethanesulfonyl chloride. Sulfonamide 1b was obtained(0.33 g, 97%) as a yellow oil. 1H NMR (400 MHz, CDCl3): δ 7.56 (d, J = 8.0 Hz, 1H), 7.25 (t, J= 7.2 Hz, 1H), 7.16 (d, J = 8.0 Hz, 1H), 7.08 (t, J = 7.2 Hz, 1H), 6.83 (bs, 1H), 5.42 (t, J = 1.6Hz, 1H), 5.02 (t, J = 0.8 Hz, 1H), 3.06-3.02 (m, 2H), 2.08 (d, J = 1.6 Hz, 3H), 1.01-0.98 (m, 2H),-0.20 (s, 9H). 13C NMR (75 Hz, CDCl3) δ 142.0, 133.4, 133.3, 128.3, 123.8, 118.2, 117.6, 48.1,24.6, 10.4, -2.1; IR (neat): 3343, 3288, 2953, 1493, 1396, 1335, 1251, 1169, 1149, 911, 861, 841,761 cm-1; HRMS (EI) calcd for [M]+ C14H23O2NSSi: 297.1204, found: 297.1213.
 

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