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Chemical Structure| 1056382-25-2 Chemical Structure| 1056382-25-2

Structure of 1056382-25-2

Chemical Structure| 1056382-25-2

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Product Details of [ 1056382-25-2 ]

CAS No. :1056382-25-2
Formula : C14H21ClFN
M.W : 257.78
SMILES Code : FC1(CCCC2=CC=CC=C2)CCNCC1.[H]Cl
MDL No. :MFCD13176614

Safety of [ 1056382-25-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 1056382-25-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1056382-25-2 ]

[ 1056382-25-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1056382-25-2 ]
  • [ 1186194-98-8 ]
  • [ 1254981-31-1 ]
YieldReaction ConditionsOperation in experiment
62% With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 110℃; for 4h;Sealed tube; D25 (0.4 g, 1.852 mmol), 4-fluoro-4-phenylpiperidine hydrochloride [C.A.S. 1056382- 25-2] (0.399 g, 1.852 mmol) and NN-DIPEA (0.645 ml, 3.704 mmol) in CH3CN (4 ml) were heated in a sealed tube at 110 0C for 4 h. The mixture was diluted with EtOAc and washed with NaHCO3 (aqueous sat. solution). The organic layer was separated, dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel; DCM as eluent). The desired fractions were collected and concentrated in vacuo to yield intermediate compound D30 (0.53 g, 62%).
 

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