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Chemical Structure| 105099-19-2 Chemical Structure| 105099-19-2

Structure of 105099-19-2

Chemical Structure| 105099-19-2

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Product Details of [ 105099-19-2 ]

CAS No. :105099-19-2
Formula : C12H14ClNO
M.W : 223.70
SMILES Code : O=C(Cl)[C@@H]1N(CC2=CC=CC=C2)CCC1

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Application In Synthesis of [ 105099-19-2 ]

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  • Downstream synthetic route of [ 105099-19-2 ]

[ 105099-19-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 105099-19-2 ]
  • [ 2835-77-0 ]
  • [ 96293-17-3 ]
YieldReaction ConditionsOperation in experiment
To a solution of 13 (20 53 g, 0 10 mol) in CH2CI2 (150 mL) was added SOCI2 (9 0 mL, 0 125 mol) with stir?ng at -2O0C for 10mm The stirring was continued at -10C for 30miotan Then 2- amino benzophenone (13 80 g, 007 mol) was added to the reaction mixture at -300C and the stirring was continued at RT for additional 10 h The reaction mixture was neutralized with Na2CO3 at 0 C until pH 8-9 The organic layer was separated and the aqueous layer was extracted with CH2CI2 (50 mL*2) The combined organic layers were washed with brine, dried and evaporated The residue was purified by column chromatography (eluting with petroleum ether and EtOAc =30 1) on silica gel to give the product as a light yellow solid (17 4 g, 76 % for two steps) 1H NMR (300 MHz, DMSO-d6) delta 11 02 (s, 1 H), 825-8 28 (d, 1 H, J= 84 Hz), 745-7 75 (m, 7H), 7 10-7 31 (m, 6H), 3 72-3 76 (d, 1 H, J= 129 Hz), 3 50-3 54 (d, 1 H, J= 12 9 Hz), 3 14-3 18 (m, 1H), 2 94-2 99 (m, 1H), 2 07-2 18 (m, 1H), 2 30-238 (m, 1 H), 1 57- 1 72 (m, 3H) LC-MS 385 (M + H)+
 

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