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Chemical Structure| 105-40-8 Chemical Structure| 105-40-8

Structure of 105-40-8

Chemical Structure| 105-40-8

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Product Details of [ 105-40-8 ]

CAS No. :105-40-8
Formula : C4H9NO2
M.W : 103.12
SMILES Code : O=C(OCC)NC
MDL No. :MFCD00041924
InChI Key :SURZCVYFPAXNGN-UHFFFAOYSA-N
Pubchem ID :7752

Safety of [ 105-40-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Application In Synthesis of [ 105-40-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 105-40-8 ]

[ 105-40-8 ] Synthesis Path-Downstream   1~35

  • 2
  • [ 109-65-9 ]
  • [ 105-40-8 ]
  • [ 59325-18-7 ]
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  • [ 50-00-0 ]
  • [ 2253-52-3 ]
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  • [ 108901-46-8 ]
  • 4
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  • [ 105-40-8 ]
  • [ 91086-49-6 ]
  • 5
  • [ 79-37-8 ]
  • [ 105-40-8 ]
  • <i>N</i>,<i>N</i>'-dimethyl-<i>N</i>,<i>N</i>'-oxalyl-bis-carbamic acid diethyl ester [ No CAS ]
  • 6
  • [ 105-40-8 ]
  • [ 141811-44-1 ]
  • [ 98553-31-2 ]
  • 9
  • [ 105-40-8 ]
  • [ 615-53-2 ]
YieldReaction ConditionsOperation in experiment
With phosphoric acid; sodium nitrite; In water; at 10 - 25℃; for 23.0h; Example 3. Preparation of nitroso-EMU EtOA N' N Me nitroso-EMU H3PO4 50% in water (683 g, 3.44 mol) is added to ethyl methylcarbamate (412 g, 4 mol) at 10 - 20 C under stirring (300 rpm). To the colorless 2-phase mixture is added NaN02 30%> in water (1123 g, 4.9 mol) at 10 - 15 C over 6 h. Nitrous gases are formed after 50% addition which are absorbed in two washing bottles containing 10% (NH4)2S04 in water. The orange solution is stirred for 17 h at 25 C and is purged with nitrogen until the remaining nitrous gases are removed. Stirring is stopped and a sample is taken from the orange organic layer for analytical analysis which shows a 76 - 82% conversion according to GCMS and NMR. The reaction mixture is extracted twice with toluene (2 x 1 1) to give 2.5 1 of a clear light orange solution which is used as such in the cyclopropanation step. Analytical data of the organic layer before toluene addition: 1H-NMR (CDC13, 400 MHz): 4.55 (q, 2 H), 3.2 (s, 3 H), 1.5 (t, 3 H) ppm. 13C-NMR (CDC13, 400 MHz): 153.8 (s), 64.5 (t), 28.0 (q), 14.25 (q) ppm. GC/MS: 132 (6%, M+), 87 (10%), 60 (48%),58 (20%), 56 (14%), 43 (83%), 30 (56%), 29 (100%).
  • 10
  • [ 105-40-8 ]
  • [ 19092-08-1 ]
  • 11
  • [ 105-40-8 ]
  • [ 132-60-5 ]
  • methyl-(2-phenyl-quinoline-4-carbonyl)-carbamic acid ethyl ester [ No CAS ]
  • 12
  • [ 541-41-3 ]
  • [ 74-89-5 ]
  • [ 105-40-8 ]
YieldReaction ConditionsOperation in experiment
90% With sodium hydroxide; In diethyl ether; water; at 5℃; n a 2-1. flask, provided with a mechanical stirrer and cooled by an ice-salt mixture, are placed 300 cc. of ether and 186 g. (2 moles) of a 33 per cent aqueous methylamine solution. When the stirred mixture has cooled to 5, 21.7 g. (2 moles) of ethyl chioroformate was added without allowing the temperature to rise above 5. When almost half of the chioroformate has been added a cold solution of 80 g. (2 moles) of pure sodium hydroxide in 1.20 cc. of water is added gradually along with the rest of the chloroformale at such a rate that the last portions of the two solutions are added simultaneously. Constant mechanical stirring throughout the addition is essential. After standing for fifteen minutes, the ether layer was separated and the aqueous solution is extracted with 100 cc, of ether. The combined ether Savers are rapidly dried by shaking for a short time with about 8 g. of potassium carbonate in two portions. The ether is then distilled and the residue was distilled under reduced pressure, the distiiiate is coiiecied at 55--60/'12 mm. The yield of colorless oil was 182 - 185 g. (88 -90 per cent of the theoretical amount).
90% With sodium hydroxide; In diethyl ether; water; at 5℃; In a 2 l flask, provided with H2O a mechanical stirrer and cooled by an ice-salt mixture, are placed 300 cc. of ether and 186 g. (2 moles) of a 33 per cent aqueous methylamine solution. When the stirred mixture was cooled to 5, 217 g. (2 moles) of ethyl chloroformate was added without allowing the temperature to rise above 5. When almost half of the chloroformate has been added a cold solution of 80 g (2 moles) of pure sodium hydroxide in 120 cc. of water was added gradually along with the rest of the chloroformate at such a rate that the last portions of the two solutions are added simultaneously. Constant mechanical stifling throughout the addition is essential. After standing for fifteen minutes, the ether layer was separated and the aqueous solution was extracted with 100 cc. of ether. The combined ether layers are rapidly dried by shaking for a short time with about 8 g. of potassium carbonate in two portions. The ether was then distilled and the residue distilled under reduced pressure, the distillate was collected at 55-60/12 mm. The yield of colorless oil was 182-185 g. (88-90 per cent of the theoretical amount).
  • 13
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  • [ 108-24-7 ]
  • [ 6092-46-2 ]
  • 14
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  • [ 100-44-7 ]
  • [ 59325-17-6 ]
  • 16
  • [ 105-40-8 ]
  • [ 41103-43-9 ]
  • 1-(2-methoxy-phenyl)-4-(3-methylcarbamoyloxy-propyl)-piperazine [ No CAS ]
  • 18
  • [ 64-17-5 ]
  • [ 624-83-9 ]
  • [ 105-40-8 ]
  • 23
  • [ 14618-10-1 ]
  • [ 105-40-8 ]
  • C11H14N2O7S [ No CAS ]
  • 24
  • [ 105-40-8 ]
  • [ 2372-33-0 ]
  • [ 64277-84-5 ]
  • 25
  • [ 105-40-8 ]
  • [ 17881-63-9 ]
  • [ 64277-83-4 ]
  • 26
  • [ 105-40-8 ]
  • [ 124-64-1 ]
  • Tetrakis-[(ethoxycarbonyl-methyl-amino)-methyl]-phosphonium; chloride [ No CAS ]
  • 28
  • [ 105-40-8 ]
  • Isocyanatophosphorsaeure-dichlorid [ No CAS ]
  • 30
  • [ 105-40-8 ]
  • [ 79-04-9 ]
  • [ 14422-90-3 ]
  • 31
  • [ 105-40-8 ]
  • [ 79-04-9 ]
  • [ 6378-52-5 ]
  • 32
  • [ 7623-09-8 ]
  • [ 105-40-8 ]
  • [ 98336-19-7 ]
  • 33
  • [ 105-40-8 ]
  • [ 768-33-2 ]
  • [ 64277-82-3 ]
  • 34
  • [ 105-40-8 ]
  • [ 941-88-8 ]
  • [ 7646-12-0 ]
  • 35
  • [ 256-96-2 ]
  • [ 105-40-8 ]
  • [ 41359-02-8 ]
 

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Technical Information

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