Structure of 1049037-18-4
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CAS No. : | 1049037-18-4 |
Formula : | C9H15F3O2 |
M.W : | 212.21 |
SMILES Code : | O=C(OC(C)(C)C)CCCC(F)(F)F |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Intermediate S-1I: (2S,3R)-tert-Butyl 6,6,6-trifluoro-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)-2-(3,3,3-trifluoropropyl)hexanoate, and Intermediate S-1J: (2R,3R)-tert-Butyl 6,6,6-trifluoro-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)-2-(3,3,3-trifluoropropyl)hexanoate To a cold (-78 C.), stirred solution of diisopropylamine (5.3 mL, 37.2 mmol) in THF (59 mL) under a nitrogen atmosphere was added n-BuLi (2.5M in hexane) (14.7 mL, 36.8 mmol). The mixture was then warmed to 0 C. to give a 0.5M solution of LDA. A separate vessel was charged with Intermediate S-1H (2.45 g, 9.17 mmol). The material was azeotroped twice with benzene (the RotoVap air inlet was fitted with a nitrogen inlet to completely exclude humidity), and then toluene (15.3 mL) was added. This solution was added to a flask containing dry lithium chloride (1.96 g, 46.2 mmol). To the resultant mixture, cooled to -78 C., was added the LDA solution (21.0 mL, 10.5 mmol) and the mixture was stirred at -78 C. for 10 min, then warmed to 0 C. for 10 min., and then cooled to -78 C. To a separate reaction vessel containing Intermediate S-1G (3.41 g, 16.07 mmol), also azeotroped twice with benzene, was added toluene (15.3 mL), cooled to -78 C. and LDA (37.0 mL, 18.5 mmol) was added. The resulting solution was stirred at -78 C. for 25 min. At this time the enolate derived from the ester was transferred via cannula into the solution of the oxazolidinone enolate and stirred at -78 C. for an additional 5 min, at which time the septum was removed and solid powdered bis(2-ethylhexanoyloxy)copper (9.02 g, 25.8 mmol) was rapidly added to the reaction vessel and the septum was replaced. The vessel was immediately removed from the cold bath and immersed into a warm water bath (40 C.) with rapid swirling and with a concomitant color change from the initial turquoise to brown. The reaction mixture was stirred for 20 min, was then poured into 5% aqueous NH4OH (360 mL) and extracted with EtOAc (2*). The combined organics were washed with brine, dried (Na2SO4), filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (Teledyne ISCO CombiFlash Rf, 0% to 60% solvent A/B=hexanes/EtOAc, REDISEP SiO2 120 g). Concentration of the appropriate fractions provided a mixture of Intermediate S-1I and Intermediate S-1J (2.87 g, 66%) as a pale yellow viscous oil. 1H NMR showed the product was a 1.6:1 mixture of diastereomers S-1I:S-1J as determined by the integration of the multiplets at 2.74 and 2.84 ppm: 1H NMR (400 MHz, CDCl3) δ ppm 4.43-4.54 (2H, m), 4.23-4.35 (5H, m), 4.01 (1H, ddd, J=9.54, 6.27, 3.51 Hz), 2.84 (1H, ddd, J=9.41, 7.28, 3.64Hz), 2.74 (1H, ddd, J=10.29, 6.27, 4.02Hz), 2.37-2.48 (2H, m, J=10.38, 6.98, 6.98, 3.51, 3.51 Hz), 2.20-2.37 (3H, m), 1.92-2.20 (8H, m), 1.64-1.91 (5H, m), 1.47 (18H, s), 0.88-0.98 (12H, m). | ||
To a cold (-78 C), stirred solution of diisopropylamine (5.3 mL, 37.2 mmol)in THF (59 mL) under nitrogen atmosphere was added n-BuLi (2.5M in hexane) (I4.7mL, 36.8 mmol), then warmed to 0 octo give a 0.5M solution ofLDA. A separate vesselwas charged with Intermediate S-IB (2.45 g, 9.17 mmol), the material was azeotropedtwice with benzene (the RotoVap air inlet was fitted with nitrogen inlet to completelyIS exclude humidity) then toluene (I5.3 mL) was added. This solution was added to a flaskcontaining dry lithium chloride (I.96 g, 46.2 mmol). To the resultant mixture, cooled to-78 C, was added LDA solution (21.0 mL, I0.5 mmol) and stirred at -78 oc for IO min,warmed to 0 oc for I 0 min then recooled to -78 C. To a separate reaction vesselcontaining Intermediate S-IA (3.4I g, I6.07 mmol), also azeotroped twice with benzene,20 was added toluene (I5.3 mL), cooled to -78 C. Next, LDA (37.0 mL, I8.5 mmol) wasadded and the resulting solution was stirred at -78 oc for 25 min. At this time the enolatederived from the ester was transferred via cannula into the solution of the oxazolidinoneenolate, stirred at -78 oc for an additional 5 min. The septum was removed and solidpowdered bis(2-ethylhexanoyloxy)copper (9.02 g, 25.8 mmol) was rapidly added to the25 reaction vessel and the septum replaced. The vessel was immediately removed from thecold bath and immersed into a warm water bath ( 40 C) with rapid swirling with aconcomitant color change from the initial turquoise to brown. The reaction mixture wasstirred for 20 min, was poured into 5% aqueous NH40H (360 mL) and extracted withEtOAc (2x). The combined organics were washed with brine, dried (Na2S04), filtered and concentrated under reduced pressure. The residue was purified by flashchromatography (Teledyne ISCO CombiFlash Rf, 0% to 60% solventA/B=hexanes/EtOAc, REDISEP Si02 I20g). Concentration of appropriate fractionsprovided a mixture oflntermediates S-IC and S-ID (2.87 g, 66%) as pale yellow viscous5 oil. 1 H NMR showed the product was a I. 6: I mixture of diastereomers S-IC: S-ID asdetermined by the integration ofthe multiplets at 2.74 and 2.84 ppm: 1H NMR (400 MHz,CDCb) 8 ppm 4.43-4.54 (2 H, m), 4.23-4.35 (5 H, m), 4.0I (I H, ddd, J=9.54, 6.27, 3.5IHz), 2.84 (I H, ddd, J=9.4I, 7.28, 3.64 Hz), 2.74 (I H, ddd, J=I0.29, 6.27, 4.02 Hz),2.37-2.48 (2 H, m, J=I0.38, 6.98, 6.98, 3.5I, 3.5I Hz), 2.20-2.37 (3 H, m), 1.92-2.20 (8IO H, m), 1.64-1.9I (5 H, m), I.47 (I8 H, s), 0.88-0.98 (I2 H, m). | ||
Preparation A-i C: (2S,3R)-tert-Butyl 6,6,6-trifluoro-3 -((S)-4-isopropyl-2-oxooxazolidine-3 -carbonyl)-2-(3 ,3 ,3 -trifluoropropyl)hexanoate,[00144j To a cold (-78 C), stirred solution of diisopropylamine (5.3 mL, 37.2 mmol)in THF (59 mL) under a nitrogen atmosphere was added n-BuLi (2.5M in hexane) (i4.7mL, 36.8 mmol), and then the mixture was warmed to 0 c to give a 0.5M solution ofLDA. A separate vessel was charged with Preparation A-iB (2.45 g, 9.i7 mmol), thematerial was azeotroped twice with benzene (the RotoVap air inlet was fitted withnitrogen inlet to completely exclude humidity), and then toluene (i5.3 mL) was added.This solution was added to a flask containing dry lithium chloride (i .96 g, 46.2 mmol).To the resultant mixture, cooled to -78 c, was added the above LDA solution (2i.O mL,iO.5 mmol) and the mixture was stirred at -78 c for iO mm, warmed to 0 c for iO mmand then cooled to -78 c. To a separate reaction vessel containing Preparation A-iA(3.4i g, i6.07 mmol), also azeotroped twice with benzene, was added toluene (i5.3 mL).The mixture was cooled to -78 c and LDA (37.0 mL, i8.5 mmol) was added, and theresulting solution was stirred at -78 c for 25 mm. At this time, the enolate derived fromthe ester was transferred via cannula into the solution of the oxazolidinone enolate andstirred at -78 c for an additional 5 mm. The septum was removed and solid powderedbis(2-ethylhexanoyloxy)copper (9.02 g, 25.8 mmol) was rapidly added to the reactionvessel and the septum replaced. The vessel was immediately removed from the cold bathand immersed into a warm water bath (40 C) with rapid swirling with a concomitantcolor change from the initial turquoise to brown. The reaction mixture was stirred for 20mm, was poured into 5% aqueous NH4OH (360 mL) and extracted with EtOAc (2x). Thecombined organics were washed with brine, dried (Na2SO4), filtered and concentratedunder reduced pressure. The residue was purified by flash chromatography (Teledyneisco combiFlash Rf, 0% to 60% solvent A/B=hexanes/EtOAc, REDISEP Si02 i2Og).concentration of appropriate fractions provided Preparation A-it (2.87 g, 66%) as a paleyellow viscous oil. ‘H NMR showed the product was a i .6: i mixture of diastereoisomersic:iD as determined by the integration of the multiplets at 2.74 and 2.84 ppm: ‘H NMR(400 MHz, cDcl3) ö ppm 4.43-4.54 (2 H, m), 4.23-4.35 (5 H, m), 4.Oi (i H, ddd, J9.54,6.27, 3.51 Hz), 2.84 (1 H, ddd, J9.41, 7.28, 3.64 Hz), 2.74 (1 H, ddd, J=i0.29, 6.27,4.02 Hz), 2.37-2.48 (2 H, m, J10.38, 6.98, 6.98, 3.51, 3.51 Hz), 2.20-2.37 (3 H, m),1.92-2.20 (8 H, m), 1.64-1.91 (5 H, m), 1.47 (18 H, s), 0.88-0.98 (12 H, m). |
To a cold (-78 C), stirred solution of diisopropylamine (5.3 mL, 37.2 mmol) in THF (59 mL) under nitrogen atmosphere was added n-BuLi (2.5M in hexane) (14.7 mL, 36.8 mmol), then warmed to 0 C to give a 0.5 M solution of LDA. A separate vessel was charged with Intermediate S-1H (2.45 g, 9.17 mmol), the material was azeotroped twice with benzene (the RotoVap air inlet was fitted with nitrogen inlet to completely exclude humidity), and then toluene (15.3 mL) was added. This solution was added to a flask containing dry lithium chloride (1.96 g, 46.2 mmol). To the resultant mixture, cooled to -78 C, was added LDA solution (21.0 mL, 10.5 mmol) and stirred at -78 C for 10 min, warmed to 0 C for 10 min, and then recooled to -78 C. To a separate reaction vessel containing Intermediate S-IG (3.41 g, 16.07 mmol), also azeotroped twice with benzene, was added toluene (15.3 mL), cooled to -78 C and LDA (37.0 mL, 18.5 mmol) was added. The resulting solution was stirred at -78 C for 25 min. At this time the enolate derived from the ester was transferred via cannula into the solution of the oxazolidinone enolate, stirred at -78 C for an additional 5 min at which time the septum was removed and solid powdered bis(2-ethylhexanoyloxy)copper (9.02 g, 25.8 mmol) was rapidly added to the reaction vessel and the septum replaced. The vessel was immediately removed from the cold bath and immersed into a warm water bath (40 C) with rapid swirling with a concomitant color change from the initial turquoise to brown. The reaction mixture was stirred for 20 min, was poured into 5% aqueous NH4OH (360 mL) and extracted with EtOAc (2x). The combined organics were washed with brine, dried (Na2S04), filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (Teledyne ISCO CombiFlash Rf, 0% to 60% solvent A/B=hexanes/EtOAc, REDISEP Si02 120g). Concentration of appropriate fractions provided a mixture of S-1I and S-1J (2.87 g, 66%) as pale yellow viscous oil. 1H NMRshowed the product was a 1.6: 1 mixture of diastereomers S-1LS-1J as determined by the integration of the multiplets at 2.74 and 2.84 ppm: 1H NMR (400 MHz, CDC13) δ ppm 4.43-4.54 (2 H, m), 4.23-4.35 (5 H, m), 4.01 (1 H, ddd, J=9.54, 6.27, 3.51 Hz), 2.84 (1 H, ddd, J=9.41, 7.28, 3.64 Hz), 2.74 (1 H, ddd, J=10.29, 6.27, 4.02 Hz), 2.37-2.48 (2 H, m, J=10.38, 6.98, 6.98, 3.51, 3.51 Hz), 2.20-2.37 (3 H, m), 1.92-2.20 (8 H, m), 1.64-1.91 (5 H, m), 1.47 (18 H, s), 0.88-0.98 (12 H, m). | ||
Intermediate S-i I: (2S,3R)-tert-Butyl 6,6,6-trifluoro-3 -((S)-4-isopropyl-2- oxooxazolidine-3 -carbonyl)-2-(3 ,3 ,3 -trifluoropropyl)hexanoate, and Intermediate S-i J: (2R,3R)-tert-Butyl 6,6,6-trifluoro-3 -((S)-4-isopropyl-2- oxooxazolidine-3 -carbonyl)-2-(3 ,3 ,3 -trifluoropropyl)hexanoate[00147j To a cold (-78 C), stirred solution of diisopropylamine (5.3 mL, 37.2 mmol) in THF (59 mL) under nitrogen atmosphere was added n-BuLi (2.5M in hexane) (14.7 mL, 36.8 mmol). The reaction mixture was warmed to 0 C to give a 0.5M solution of LDA. A separate vessel was charged with Intermediate S-1H (2.45 g, 9.17 mmol), the material was azeotroped twice with benzene (the RotoVap air inlet was fitted withnitrogen inlet to completely exclude humidity) then toluene (15.3 mL) was added. This solution was added to a flask containing dry lithium chloride (1.96 g, 46.2 mmol). To the resultant mixture, cooled to -78 C, was added LDA solution (21.0 mL, 10.5 mmol) and stirred at -78 C for 10 mm, warmed to 0 C for 10 mm then recooled to -78 C. To a separate reaction vessel containing Intermediate S-1G (3.41 g, 16.07 mmol), alsoazeotroped twice with benzene, was added toluene (15.3 mL), cooled to -78 C and LDA (37.0 mL, 18.5 mmol) was added, the resulting solution was stirred at -78 C for 25 mm. At this time the enolate derived from the ester was transferred via cannula into the solution of the oxazolidinone enolate, stirred at -78 C for an additional 5 mm at which time the septum was removed and solid powdered bis(2-ethylhexanoyloxy)copper (9.02g, 25.8 mmol) was rapidly added to the reaction vessel and the septum replaced. The vessel was immediately removed from the cold bath and immersed into a warm water bath (40 C) with rapid swirling with a concomitant color change from the initial turquoise to brown. The reaction mixture was stirred for 20 mm, was poured into 5% aqueous NH4OH (360 mL) and extracted with EtOAc (2x). The combined organics werewashed with brine, dried (Na2SO4), filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (Teledyne ISCO CombiFlash Rf, 0% to 60% solvent A/B=hexanes/EtOAc, REDISEP Si02 120g). Concentration of appropriate fractions provided a mixture of Intermediates S-lI and S-1J (2.87 g, 66%) aspale yellow viscous oil. ‘H NMR showed the product was a 1.6:1 mixture ofdiastereomers S-i I: S-i J as determined by the integration of the multiplets at 2.74 and2.84 ppm: ‘H NMR (400 MHz, CDC13) ö ppm 4.43-4.54 (2 H, m), 4.23-4.35 (5 H, m),4.01 (1 H, ddd, J9.54, 6.27, 3.51 Hz), 2.84 (1 H, ddd, J9.41, 7.28, 3.64 Hz), 2.74 (1 H,ddd, J10.29, 6.27, 4.02 Hz), 2.37-2.48 (2 H, m, J10.38, 6.98, 6.98, 3.51, 3.51 Hz),2.20-2.37 (3 H, m), 1.92-2.20 (8 H, m), 1.64-1.9 1 (5 H, m), 1.47 (18 H, s), 0.88-0.98 (12H, m). | ||
A 0.5 M solution of LDA was prepared by the addition of a solutionof 2.5 M n-BuLi in hexanes (14.7 mL, 36.8 mmol) to a cold(-78 C) solution of diisopropylamine (5.3 mL, 37.2 mmol) inTHF (59 mL) under N2. The solution was stirred at 0 C for 15min. A solution of <strong>[1401067-00-2](S)-4-isopropyl-3-(5,5,5-trifluoropentanoyl)oxazolidin-2-one</strong> (2.45 g, 9.2 mmol) in toluene (15.3 mL)was added with stirring to dry LiCl (1.96 g, 46.2 mmol). Themixture was cooled to -78 C, and the freshly prepared 0.5 Msolution of LDA (21.0 mL, 10.5 mmol) was added. The reactionmixture was stirred at -78 C for 10 min, at 0 C for 10 min, andcooled to -78 C. Meanwhile, the freshly prepared 0.5 M solutionof LDA (37.0 mL, 18.5 mmol) was added to a cold (-78 C)solution of tert-butyl 5,5,5-trifluoropentanoate (3.41 g, 16.1mmol) in toluene (15.3 mL). After 25 min of stirring at -78 C, this reaction mixture was transferred via cannula into the cold(-78 C) LiCl/enolate solution. After an additional 5 min of stirringat -78 C, solid powdered bis(2-ethylhexanoyloxy)copper(9.02 g, 25.8 mmol) was rapidly added to the reaction vesselthrough a funnel, and the flask was rapidly recapped with aseptum. The vessel was immediately removed from the coldbath and immersed into a warm (40 C) water bath with rapidswirling. The reaction mixture changed from the initial turquoiseto a dark green then to a brown color. After 20 min ofstirring, the reaction mixture was poured into 5% aq NH4OH(360 mL) and extracted with EtOAc (2 × 150 mL). The combinedorganic layer was washed with brine, dried (Na2SO4), filtered,and concentrated under reduced pressure. The residue waspurified by flash chromatography (Teledyne ISCO CombiFlashRf, 0-60% EtOAc in hexanes, RediSep silica gel, 120 g). Concentrationof appropriate fractions provided the product tert-butyl(2S,3R)-6,6,6-trifluoro-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)-2-(3,3,3-trifluoropropyl)hexanoate (2.87 g, 66%) as apale yellow oil. 1H NMR indicated that the product was a 1.6:1mixture of diastereomers, as determined by integration of themultiplets at 2.74 and 2.84 ppm. 1H NMR (400 MHz, CDCl3): δ =4.43-4.54 (2 H, m), 4.23-4.35 (5 H, m), 4.01 (1 H, ddd, J = 9.54,6.27, 3.51 Hz), 2.84 (1 H, ddd, J = 9.41, 7.28, 3.64 Hz), 2.74 (1 H,ddd, J = 10.29, 6.27, 4.02 Hz), 2.37-2.48 (2 H, m), 2.20-2.37 (3 H,m), 1.92-2.20 (8 H, m), 1.64-1.91 (5 H, m), 1.47 (18 H, s), 0.88-0.98 (12 H, m). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Intermediate S-1: (2R,3S)-3-(tert-Butoxycarbonyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid, and Intermediate S-1E: (2R,3R)-3-(tert-Butoxycarbonyl)-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoic acid [0289] [0290] To a cool (0 C.), stirred solution of Intermediate S-1I and Intermediate S-1J (4.54 g, 9.51 mmol) in THF (140 mL) and water (42 mL) were sequentially added hydrogen peroxide (30% in water) (10.3 g, 91 mmol) and LiOH (685.3 mg, 28.6 mmol). The mixture was stirred for 1 hr. At this time the reaction vessel was removed from the cold bath and then stirred for 1.5 hr. To the reaction mixture were added saturated NaHCO3 (45 mL) and saturated Na2SO3 (15 mL), and then the mixture was partially concentrated under reduced pressure. The resulting crude solution was extracted with DCM (3×). The aqueous phase was acidified to pH1-2 with 1N HCl, extracted with DCM (3×) and then EtOAc (1×). The combined organics were washed with brine, dried (Na2SO4), filtered and concentrated under reduced pressure to provide a mixture of Intermediates S-1 and S-1E (3.00 g, 86%) as a colorless oil: 1H NMR (400 MHz, CDCl3) δ ppm 2.76-2.84 (1H, m, diastereomer 2), 2.64-2.76 (3H, m), 2.04-2.35 (8H, m), 1.88-2.00 (4H, m), 1.71-1.83 (4H, m), 1.48 (9H, s, diastereomer 1), 1.46 (9H, s, diastereomer 2); 1H NMR showed a 1.7:1 mixture of S-1E:S-1F by integration of the peaks for the t-butyl groups. |
Tags: 1049037-18-4 synthesis path| 1049037-18-4 SDS| 1049037-18-4 COA| 1049037-18-4 purity| 1049037-18-4 application| 1049037-18-4 NMR| 1049037-18-4 COA| 1049037-18-4 structure
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P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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