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Chemical Structure| 10449-07-7 Chemical Structure| 10449-07-7

Structure of 10449-07-7

Chemical Structure| 10449-07-7

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Product Details of [ 10449-07-7 ]

CAS No. :10449-07-7
Formula : C6H7ClN2
M.W : 142.59
SMILES Code : NNC1=CC=CC=C1Cl
MDL No. :MFCD00982023

Safety of [ 10449-07-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H350
Precautionary Statements:P264-P270-P203-P280-P301+P316-P321-P330-P318-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 10449-07-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10449-07-7 ]

[ 10449-07-7 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 21168-41-2 ]
  • [ 10449-07-7 ]
  • [ 1026185-79-4 ]
  • 2
  • [ 391-12-8 ]
  • [ 10449-07-7 ]
  • 3-[(2-chloro-phenyl)-hydrazono]-7-trifluoromethyl-1,3-dihydro-indol-2-one [ No CAS ]
  • 3
  • [ 21279-62-9 ]
  • [ 10449-07-7 ]
  • 3-(2-(2-chlorophenyl)hydrazinyl)pyrazine-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
17% With pyridine; In methanol; at 140℃; under 112.51100000000001 Torr; for 0.5h;Microwave irradiation; Compound 7 is prepared by reaction of 2-chlorophenylhydrazine (3 mmol) with 3- chloropyra.zine-2-carboxamide (III, 1 mmol) in 3 mL methanol and pyridine (1 mmol). The reaction is performed in a microwave reactor at the temperature 140C, pressure 15 kPa and an output of 120 W during 30 mm. After completing the reaction, product 7 was isolated and purified by column chromatography on silica gel (mobile phase: hexane I ethyl acetate 1:1), yield 17%. Analytical data for compound 7: Brown crystalline solid; Mp. = 193.6-194.7C; Elemental analysis calculated for C11H10C1N50 (m.w. 263.68): 50.10% C, 3.82% H, 26.56% N; found 50.36% C, 3.94% H, 26.68% N; IR (ATR-Ge, cnf?): 3448 (-NH-), 3315 (-CONH2), 1679 (-C=O), 1595, 1536, 1490, 1412 (pyr); 1H-NMR (300 MHz, CDC13) 8 10.06 (IH, bs, NM), 8.31 (1H, bs, NH), 8.26 (1H, J= 2.4 Hz, H5), 7.96 (1H, d, J=? 2.4 Hz, H6), 7.88 (1H, bs, NH2), 7.67 (1H, bs, NH2), 7.28 (lH, dd, J= 7.8 Hz, J- 1.5 Hz, H3?), 7.10-7.05 (1H, m, H5?), 6.78 (1H, dd, J- 7.8 Hz, J 1,5 Hz, H6?), 6.72 (1H, dt, J= 7.8 Hz, J 1.5 Hz, H4?); L3C NMR (75 MHz, DM80) 8 168.5, 155.3, 146.4, 145.1, 132.6, 129.4, 128.0, 127.5, 119.5, 117.4, 113.0; Lipophilicity: calc. value log P = 0,34; experimental determined value log k =0.0872.
  • 4
  • [ 3314-30-5 ]
  • [ 10449-07-7 ]
  • (E)-2-((2-(2-chlorophenyl)hydrazono)methyl)-1H-benzo[d]imidazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
72.6% In methanol; at 20℃; for 2h; General procedure: The equimolar aldehyde 3a?3d (1 mmol) and substituted phenylhydrazine 5a?5s (1 mmol) weremixed in CH3OH (10 mL) and stirred at room temperature [18]. After about 2 h, the reaction wascompleted (monitored by TLC). The residual crude was purified via silica gel column chromatogramusing a gradient mixture of petroleum ether and ethyl acetate to obtain the pure target compounds6a?6ai (in 45?80percent yield).
 

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