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Chemical Structure| 1044870-30-5 Chemical Structure| 1044870-30-5

Structure of 1044870-30-5

Chemical Structure| 1044870-30-5

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Product Details of [ 1044870-30-5 ]

CAS No. :1044870-30-5
Formula : C18H18N2O4
M.W : 326.35
SMILES Code : O=C1NC(C2=CC(C)=C(O)C(C)=C2)=NC3=C1C(OC)=CC(OC)=C3

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Application In Synthesis of [ 1044870-30-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1044870-30-5 ]

[ 1044870-30-5 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 96-49-1 ]
  • [ 1044870-30-5 ]
  • [ 1044870-39-4 ]
YieldReaction ConditionsOperation in experiment
95% With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 12 h; Compound 10A (3.26 g, 10 mmol) was added to a 100 mL single-mouth bottle.Compound 11 is ethylene carbonate (0.88 g, 10 mmol),Add 30 mL of N,N-dimethylformamide to dissolve it.At the same time, potassium carbonate (1.38 g, 10 mmol) was added.Warm the system to 110 ° C,The reaction was refluxed for 12 hours.After the reaction is over,Add 20 mL of water to the reaction system.Extract three times with dichloromethane (3*20 mL),Combine the organic phase,Dry with anhydrous sodium sulfate,filter,Distilling under reduced pressure to obtain a mixture,Purified by column chromatography (the eluent is petroleum ether / ethyl acetate,Volume ratio 2:1),A yellow solid RVX-208 (3.51 g, yield 95percent) was obtained.
References: [1] Patent: CN108484510, 2018, A, . Location in patent: Paragraph 0041.
 

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