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Chemical Structure| 1044518-75-3 Chemical Structure| 1044518-75-3

Structure of 1044518-75-3

Chemical Structure| 1044518-75-3

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Product Details of [ 1044518-75-3 ]

CAS No. :1044518-75-3
Formula : C13H22O5
M.W : 258.31
SMILES Code : CC1(C)O[C@H](CC(OC(C)(C)C)=O)C[C@H](C=O)O1
MDL No. :N/A

Safety of [ 1044518-75-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 1044518-75-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1044518-75-3 ]

[ 1044518-75-3 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1044518-75-3 ]
  • [ 289042-12-2 ]
YieldReaction ConditionsOperation in experiment
14.8 g With sodium hydride In tetrahydrofuran; mineral oilReflux Will [4-(4-fluorophenyl)-6-isopropyl2-(N-Methyl-N-methanesulfonamido)-5-pyrimidinyl]Triphenylphosphonium bromideDissolve 50g in 200ml THF and put it in Example 1.4R-cis)-6-Formaldehyde-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester18g, slowly added60percent of sodium hydrogen 4.2g, after the completion of feeding, slowly warming reflux reaction 2-3 hours, TLC showed the reaction after the end of the reaction, the material was slowly added to water, extracted with toluene 300ml * 2 twice, combined organic saturated brine 200ml After washing, 10 g of anhydrous sodium sulfate was added for drying and suction filtration. The filtrate was concentrated to dryness under reduced pressure, and the residue was crystallized from methanol to give (4R,6S)-6-[(1E)-2-[4-(4-fluorobenzene). (methyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidine]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid Tert-butyl ester crude product 19.5g, purity (HPLC) 94.6percentThe above crude product 18.0 g and 90 g of methanol were heated to about 60° C. After thawing, the solution was slowly cooled to about 0° C. and crystallized for 3-4 hours. After suction filtration, the pure product was dried to 14.8 g, and the purity (HPLC) was 99.5percent.
References: [1] Patent: CN103113357, 2017, B, . Location in patent: Paragraph 0045; 0046.
 

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