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Type HazMat fee for 500 gram (Estimated)
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Limited Quantity USD 15-60
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Chemical Structure| 10443-65-9 Chemical Structure| 10443-65-9

Structure of 10443-65-9

Chemical Structure| 10443-65-9

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Product Details of [ 10443-65-9 ]

CAS No. :10443-65-9
Formula : C3H3BrO2
M.W : 150.96
SMILES Code : C=C(Br)C(O)=O
MDL No. :MFCD00014333
InChI Key :HMENQNSSJFLQOP-UHFFFAOYSA-N
Pubchem ID :82633

Safety of [ 10443-65-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314-H335
Precautionary Statements:P261-P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 10443-65-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10443-65-9 ]

[ 10443-65-9 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 600-05-5 ]
  • [ 10443-65-9 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; sodium hydroxide; In water; Step A Synthesis of 2-bromo-2-propenoic acid as an intermediate A stirred solution of 84.9 grams (0.366 mole) of <strong>[600-05-5]2,3-dibromopropionic acid</strong> in an appropriate amount of water was cooled to 0+-5. To this was added dropwise 184 ml of aqueous 2N sodium hydroxide at such a rate that the reaction mixture temperature did not exceed 10. An additional 184 ml of aqueous 2N sodium hydroxide was added dropwise. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature where it was stirred for one hour. The clear reaction mixture was acidified with 47 ml of concentrated hydrochloric acid and extracted with three portions of 400 ml each of diethyl ether. The combined extracts were dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to give a solid residue. The solid was recrystallized from hexane to give 41.6 grams of 2-bromo-2-propenoic acid; mp 69.5-71.5.
  • 2
  • [ 10443-65-9 ]
  • [ 600-05-5 ]
  • 3
  • [ 10443-65-9 ]
  • [ 10035-10-6 ]
  • [ 600-05-5 ]
  • 4
  • [ 600-05-5 ]
  • [ 7664-41-7 ]
  • [ 10443-65-9 ]
  • 5
  • [ 600-05-5 ]
  • alcoholic KOH-solution [ No CAS ]
  • [ 10443-65-9 ]
  • 6
  • [ 600-05-5 ]
  • [ 372-09-8 ]
  • [ 10443-65-9 ]
  • [ 702-90-9 ]
  • 7
  • [ 20876-36-2 ]
  • [ 10443-65-9 ]
  • 2-bromo-N-(2-oxoindolin-5-yl)acrylamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
73% With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 18h;Cooling with ice; General procedure: To an ice-cooled solution of amino derivative 13-18 (1.00 mmol) in dry DMF (5.0 mL) were added a mixture of EDCI (383 mg,2.00 mmol) and alpha-bromoacrylic acid (2.00 mmol, 306 mg). The reaction mixturewas stirred at room temperature for 18 h and then concentrated under reduced pressure. The residue was dissolved with a mixture of CH2Cl2 (15 mL) and water (5 mL), and the organicphase was washed with brine (5 mL), dried over Na2SO4 andevaporated to dryness in vacuo. The resulting crude residue waspurified by column chromatography on silica gel.
 

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