Structure of 10406-25-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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CAS No. : | 10406-25-4 |
Formula : | C8H8N2 |
M.W : | 132.16 |
SMILES Code : | N#CC1=CC=C(CN)C=C1 |
MDL No. : | MFCD00025578 |
InChI Key : | LFIWXXXFJFOECP-UHFFFAOYSA-N |
Pubchem ID : | 82608 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H332-H335 |
Precautionary Statements: | P280-P305+P351+P338-P310 |
Num. heavy atoms | 10 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.12 |
Num. rotatable bonds | 1 |
Num. H-bond acceptors | 2.0 |
Num. H-bond donors | 1.0 |
Molar Refractivity | 38.83 |
TPSA ? Topological Polar Surface Area: Calculated from |
49.81 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
1.41 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
0.44 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
0.87 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
0.85 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
1.41 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
1.0 |
Log S (ESOL):? ESOL: Topological method implemented from |
-1.31 |
Solubility | 6.4 mg/ml ; 0.0485 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (Ali)? Ali: Topological method implemented from |
-1.05 |
Solubility | 11.7 mg/ml ; 0.0883 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-2.49 |
Solubility | 0.424 mg/ml ; 0.00321 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
Yes |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-6.79 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
1.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.16 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | With triethylamine; In dichloromethane; at 20℃; | To a round-bottom flask equipped with a stir bar was added 17a-b (1.0 eq), Boc2O (1.1 eq), CH2Cl2 (10mL/mmol), and triethylamine (1.5 eq). The reaction mixture was stirred at room temperature overnight. The reaction was concentrated in vacuo and partitioned between ethyl ether and 1M HCl. The organic layer were separated, washed with saturated NaHCO3 and brine, dried over MgSO4, and concentrated in vacuo to give a white crystalline solid. 4.2.4.2 128 tert-Butyl (4-cyanobenzyl)carbamate (18a) Yield: 93%. MP: 114-116C. 1H NMR (400MHz, CDCl3) delta 7.62 (d, J=7.9Hz, 2H, -ArH), 7.39 (d, J=8.5Hz, 2H, -ArH), 4.96 (s, 1H, -NH-), 4.37 (d, J=5.9Hz, 2H, -CH2-), 1.46 (s, 9H, -CH3) |
93% | With triethylamine; In dichloromethane; at 20℃; | General procedure: To a round-bottom flask equipped with a stir bar was added 27a-b (1.0 eq), Boc2O (1.1 eq), CH2Cl2 (10 mL/mmol), and triethylamine (1.5 eq). The reaction mixture was stirred at room temperature overnight. The reaction was concentrated in vacuo and partitioned between ethyl ether and 1 M HCl. The organic layer were separated, washed with saturated NaHCO3, brine, dried over MgSO4, and concentrated in vacuo to give a white crystalline solid. Example 86 Synthesis of 210 tert-Butyl (4-cyanobenzyl) carbamate (28a) (0243) The synthesis follows the general procedure described in Example 85. Yield: 93%. MP: 114-116 C. 1H NMR (400 MHz, CDCl3) delta 7.62 (d, J=7.9 Hz, 2H, -ArH), 7.39 (d, J=8.5 Hz, 2H, -ArH), 4.96 (s, 1H, -NH-), 4.37 (d, J=5.9 Hz, 2H, -CH2-), 1.46 (s, 9H, -CH3). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
48% | In N,N-dimethyl-formamide; at 60℃; | Example 5; Step A; 4-Cyanolbenzylamine (1.1 g, 8.33 mmol), 4,6-pyrimidine dicarboxylic acid methyl ester (1.77 g, 8.33 mmol) were dissolved in N,N-dimethylformamide (20 mL). The reaction was stirred 60 C. overnight and concentrated. The brown solid was purification with ethyl acetate and hexane (gradient) to give product as light brown solid (1.18 g, 48% yield). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 4-methyl-morpholine; In hexane; water; ethyl acetate; N,N-dimethyl-formamide; | a Boc-D-Phenylalanylproline (p-cyanobenzyl)amide 2.0 g (14.6 mmol) of isobutyl chloroformate were added in 2 min to a solution of 5.1 g (14.2 mmol) of <strong>[38675-10-4]Boc-D-Phe-Pro-OH</strong> and 1.53 g (15.2 mmol) of N-methylmorpholine in 15 ml of DMF at -15 C., the mixture was stirred for 10 min and then a solution of 1.9 g (14.2 mmol) of p-cyanobenzylamine (W. Walter et al., Ann. 660, 1962, 60) and 1.53 g of N-methylmorpholine in 3 ml of DMF was added. After stirring at -15 C. for 3 h, a TLC check (CH2 Cl2 /MeOH, 9/1) showed no detectable starting compounds. For isolation, the reaction mixture was poured into 200 ml of water, when an oil separated out and, after a short time, solidifed and was broken up and filtered off with suction. The still moist residue was dissolved in a mixture of 250 ml of ethyl acetate and 50 ml of ether and washed successively with a 5% strength aqueous citric acid, bicarbonate and saturated sodium chloride solutions. After drying over Na2 SO4, the solvent was removed by distillation under reduced pressure, and the residue was mixed with n-hexane and then filtered off with suction. Recrystallization from 50 ml of ethyl acetate afforded 5.6 g of TLC-pure product, m.p. 156-157 C. |
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