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Chemical Structure| 1040264-48-9 Chemical Structure| 1040264-48-9
Chemical Structure| 1040264-48-9

Ethyl 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzoate

CAS No.: 1040264-48-9

4.5 *For Research Use Only !

Cat. No.: A891918 Purity: 95%

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Product Details of [ 1040264-48-9 ]

CAS No. :1040264-48-9
Formula : C17H24N2O7
M.W : 368.38
SMILES Code : O=C(C1C([N+](=O)[O-])=CC(OC)=C(OCCCN2CCOCC2)C=1)OCC

Safety of [ 1040264-48-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 1040264-48-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1040264-48-9 ]

[ 1040264-48-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1146162-38-0 ]
  • [ 57616-74-7 ]
  • [ 1040264-48-9 ]
YieldReaction ConditionsOperation in experiment
98% With potassium carbonate; In 1,4-dioxane; for 7h;Reflux;Product distribution / selectivity; Example 7: Preparation of 4-methoxy-5-(3-morpholin-4-ylpropoxy)-2-nitro benzoic acid ethyl ester; To a mixture of 5-hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester (55g) and anhydrous potassium carbonate (94.4g) in dioxane (275ml), <strong>[57616-74-7]4-(3-chloropropyl)-morpholine hydrochloride</strong> (78.5g) was added and refluxed for 7 hours. After completion of reaction, the solvent was distilled under reduced pressure. The resulting residue was extracted with ethyl acetate (770 ml). The organic layer was distilled under vacuum. Cyclohexane (200 ml) and isopropyl ether (100 ml) was added to the resulting residue and stirred. The resulting product was filtered, washed with cyclohexane and dried to give 82g (98%) of the title compound having purity 97.5% by HPLC.
 

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