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Chemical Structure| 10388-19-9 Chemical Structure| 10388-19-9

Structure of 3-Iodobenzamide
CAS No.: 10388-19-9

Chemical Structure| 10388-19-9

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Product Details of [ 10388-19-9 ]

CAS No. :10388-19-9
Formula : C7H6INO
M.W : 247.03
SMILES Code : NC(=O)C1=CC(I)=CC=C1
MDL No. :MFCD00143169

Safety of [ 10388-19-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 10388-19-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10388-19-9 ]

[ 10388-19-9 ] Synthesis Path-Downstream   1~1

  • 1
  • bis(diphenyl-phosphino)propane [ No CAS ]
  • [ 10388-19-9 ]
  • [ 4481-28-1 ]
YieldReaction ConditionsOperation in experiment
87% With triethylamine;palladium diacetate; In water; ethyl acetate; acetonitrile; B. 3-Carboxybenzamide A mixture of 3-iodobenzamide (4.28 g, 17.3 mmol), water (25.00 g, 1387.7 mmol), triethylamine (8.00 g, 79.1 mmol), palladium(II) acetate (0.28 g, 1.2 mmol), and bis(diphenylphosphino)propane (0.52 g, 1.3 mmol) in acetonitrile (50 mL) was pressurized to 40 psi with carbon monoxide and the pressure was released. After six such cycles, the bottle was pressurized again and the contents were stirred at 85 C. for 3 h. The reaction mixture was cooled to room temperature and depressurized. The solvent was evaporated and ethyl acetate (200 mL) was added. The solution was filtered and then extracted with water (2*200 mL). The combined aqueous layers were acidified with 12 M HCl to pH 0. The solid was filtered off and air-dried to give 3-carboxybenzamide (1.93 g, 87%) as a yellow solid
 

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