10374-51-3|5-(Hydroxymethyl)dihydrofuran-2(3H)-one| Ambeed

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Quality Control of [ 10374-51-3 ] Purity: 95% SDS Specification

COA

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Product Details of [ 10374-51-3 ]

CAS No. :	10374-51-3
Formula :	C₅H₈O₃
M.W :	116.12
SMILES Code :	O=C1OC(CO)CC1
MDL No. :	MFCD00506240
InChI Key :	NSISJFFVIMQBRN-UHFFFAOYSA-N
Pubchem ID :	98431

Safety of [ 10374-51-3 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319
Precautionary Statements:	P264-P280-P337+P313-P305+P351+P338-P302+P352-P332+P313-P362

Computational Chemistry of [ 10374-51-3 ] Show Less

Physicochemical Properties

Num. heavy atoms	8
Num. arom. heavy atoms	0
Fraction Csp3	0.8
Num. rotatable bonds	1
Num. H-bond acceptors	3.0
Num. H-bond donors	1.0
Molar Refractivity	26.48
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	46.53 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	0.93
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	-0.44
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	-0.32
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	-0.38
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	0.69
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	0.1

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-0.22
Solubility	70.5 mg/ml ; 0.607 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-0.07
Solubility	98.4 mg/ml ; 0.848 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-0.16
Solubility	79.8 mg/ml ; 0.687 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	No
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	No
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-7.32 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	1.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	0.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<1.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	2.03

Application In Synthesis of [ 10374-51-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 10374-51-3 ]

[ 10374-51-3 ] Synthesis Path-Downstream 1~35

1
[ 591-80-0 ]
[ 10374-51-3 ]

Yield	Reaction Conditions	Operation in experiment
99%	With hydrogenchloride; dihydrogen peroxide; In methanol; formic acid;	EXAMPLE 56 (+-)-Dihydro-5-Hydroxymethyl-2(3H) -Furanone STR89 To a stirring solution of 19% hydrogen peroxide (35 mL, 0.20 mol) in 85% aqueous formic acid (60 mL) at 50-55 C. was added over a 15 min period a solution of 4-pentenoic acid (15 g, 0.15 mol) in 85% aqueous formic acid (30 mL). The solution was maintained at this temperature for 2 h. Concentration gave an oil which comprised of a mixture of the desired compound and the corresponding formate ester. The oil was then stirred in methanol (50 mL) containing concentrated hydrochloric acid (1 mL) for 3 h. Concentration gave the desired compound as an oil (17.2 g, 99%). 1 H NMR (300 MHz, CDCl3) delta: 4.60 (m, 1H, H-5), 3.89 (dd, 1H, H-6, J=2.7 HZ and 12.6 Hz), 3.63 (dd, 1H, H-6', J=4.5 HZ and 12.3 Hz), 2.6 (m, 2H, H-3), 2.3 (m, 3H, H-4, OH).
97%	With formic acid; dihydrogen peroxide; at 50℃; for 2.25h;	4-pentenoic acid (2 g, 20 mmol) was dissolved in formic acid (5 mL), and added dropwise into formic acidsolution (20 mL) containing 35% of hydrogen peroxide (28 mmol) at 50 C over 15 min. At this temperature, the mixturewas stirred for 2 h, and distilled under reduced pressure to give the product 2-keto-5-hydroxymethyl-tetrahydrofuran (2g, yield 97%).
88%	With dihydrogen peroxide; In tert-butyl alcohol;	EXAMPLE 5 A total of 2 ml of 30% by weight hydrogen peroxide aqueous solution was added dropwise to a stirred mixture of 1.00 g (10 mmol) of 4-pentenoic acid, 25 mg (0.1 mmol) of tungstic acid, and 15 ml of t-butyl alcohol at room temperature, followed by stirring at 70C for 10 hours. As a result, gamma-hydroxymethyl-gamma-butyrolactone was produced in a yield of 88%.

With N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamineiron(II) bis(triflate); dihydrogen peroxide; In water; acetonitrile; for 0.166667h;Inert atmosphere; Schlenk technique;

General procedure: Epoxidations were performed in 25-mL Schlenk tubes under an inert atmosphere. In a typical run, the tube was charged with 1 equiv of catalyst (typically about 15mg), degassed acetonitrile (20mL) and 200 equiv of substrate. 600 equiv of the oxidant H2O2 (30% w/v in water) were added via syringe over a two-minute period, often resulting in an immediate color change to brown. This color faded to a pale orange for most substrates over a period of 30s. The reaction was allowed to stir for a total of 10min, and then was quenched by pouring the solution into an Erlenmeyer flask containing silica gel and anhydrous magnesium sulfate. The solution was passed through a short column of silica gel, and solvent evaporated under moderate vacuum. As a control, samples of substrates were taken through this workflow without use of catalyst, and analyzed gravimetrically and by 1H NMR. Pure substrate was recovered with no significant mass loss (typical recovery 98%). For other catalyst:substrate:oxidant ratios, the concentration of catalyst was kept constant, and amounts of substrate and oxidant varied. The products were analyzed by 1H NMR in CDCl3 with a relaxation delay of 10s. 1H NMR shifts of the epoxide products matched those reported in the literature [22,36-39]. For oleic acid and ethyl oleate, the shift of the CH3 group of C18 does not change between the starting materials and products. This signal was therefore used as an internal standard to measure conversions by comparing the integrations of the alkene signals relative to the methyl signals [36]. Similarly, epoxide selectivities were calculated from the integrations of the epoxide signals and the methyl signals. For undecylenic acid and methyl undecenoate, a similar approach utilized the methylene group next to the carboxylic acid group as an internal standard. For the epoxidation of 4-pentenoic acid and 5-hexenoic acid, conversions were determined by comparing the integrations of the alkene signals with those of the epoxide and lactone signals. GC-MS data was used to confirm the presence of two major products only, the epoxide and the lactone [38]. Owing to the limit of sensitivity of NMR, in experiments where epoxide or lactone was the only product clearly detected, selectivities of >95% are reported, as low concentrations of other products can not be ruled out. Selected spectra and GC-MS chromatograms are available in the Supplemental information.

References: [1]Patent: US5789394,1998,A .
[2]Patent: EP3348548,2018,A1 .Location in patent: Paragraph 0079.
[3]Patent: EP1302469,2003,A1 .
[4]Advanced Synthesis and Catalysis,2007,vol. 349,p. 2685 - 2689.
[5]Advanced Synthesis and Catalysis,2013,vol. 355,p. 947 - 956.
[6]Nauchnye Trudy, Erevanskii Gosudarstvennyi Universitet, Seriya Khimicheskikh Nauk,1954,vol. 44,p. 35,38.
Chem.Abstr.,1959,p. 21649.
[7]Helvetica Chimica Acta,1940,vol. 23,p. 653.
[8]Tetrahedron,1985,vol. 41,p. 2727 - 2736.
[9]Justus Liebigs Annalen der Chemie,1892,vol. 268,p. 34.
[10]Inorganica Chimica Acta,2014,vol. 413,p. 149 - 159.
[11]Patent: WO2019/244047,2019,A1 .

2
[ 66679-29-6 ]
[ 10374-51-3 ]

References: [1]Justus Liebigs Annalen der Chemie,1892,vol. 268,p. 34.

3
[ 10374-51-3 ]
[ 38806-07-4 ]

References: [1]Chemical and pharmaceutical bulletin,1972,vol. 20,p. 1217 - 1229.

4
[ 10374-51-3 ]
[ 108-24-7 ]
[ 5904-80-3 ]

References: [1]Helvetica Chimica Acta,1987,vol. 70,p. 1569 - 1582.

5
[ 10374-51-3 ]
[ 39928-72-8 ]

References: [1]Journal of Organic Chemistry,1984,vol. 49,p. 3027 - 3029.

6
[ 10374-51-3 ]
[ 32730-32-8 ]

References: [1]Journal of Organic Chemistry,1984,vol. 49,p. 3027 - 3029.

7
[ 10374-51-3 ]
[ 1729-32-4 ]

References: [1]Journal of Organic Chemistry,1984,vol. 49,p. 3027 - 3029.

8
[ 10374-51-3 ]
sodium 2,3-dideoxy-D,L-glycero-pentonate [ No CAS ]

References: [1]Carbohydrate Research,1990,vol. 203,p. 271 - 280.

9
[ 592-42-7 ]
[ 10374-51-3 ]

References: [1]Journal of the Chemical Society. Chemical communications,1992,p. 626 - 627.

10
[ 86310-98-7 ]
[ 10374-51-3 ]

References: [1]Tetrahedron,1985,vol. 41,p. 2727 - 2736.

11
[ 73927-91-0 ]
[ 107-18-6 ]
[ 10374-51-3 ]

References: [1]Tetrahedron Letters,1984,vol. 25,p. 3939 - 3942.

12
[ 10374-51-3 ]
[ 74-88-4 ]
[ 96845-45-3 ]

References: [1]Journal of Organic Chemistry,1985,vol. 50,p. 2764 - 2766.

13
[ 10374-51-3 ]
[ 18162-48-6 ]
[ 193095-16-8 ]

References: [1]Journal of Medicinal Chemistry,1997,vol. 40,p. 168 - 180.

14
[ 27620-83-3 ]
[ 10374-51-3 ]

References: [1]Journal of Medicinal Chemistry,1997,vol. 40,p. 168 - 180.

15
[ 23107-52-0 ]
[ 10374-51-3 ]

References: [1]Tetrahedron Letters,1996,vol. 37,p. 7583 - 7586.

16
[ 144-48-9 ]
[ 107-18-6 ]
[ 10374-51-3 ]

References: [1]Tetrahedron Letters,1999,vol. 40,p. 519 - 522.

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 7 6.0 g 4,5-epoxypentane carboxylic acid methyl ester is shaken in a mixture of 10 ml ether and 10 ml 2 n HCl for 1 hour. The ether is then separated and the aqueous phase perforated with ether. From the combined dried ethereal phases 3.7 g dihydro-5-hydroxymethyl-(3H)-furanone is obtained after removal of the ether in vacuum.
		EXAMPLE 10 6.0 g 4,5-epoxypentane carboxylic acid methyl ester is shaken in a mixture of 10 ml ether and 10 ml 2n HCl for 1 hour. The ether is then separated and the aqueous phase perforated with ether. From the combined dried ethereal phases 3.7 g dihydro-5-hydroxymethyl-(3H)-furanone is obtained after removal of the ether in vacuum.

18
δ-bromo-γ-valerolactone [ No CAS ]
[ 10374-51-3 ]

References: [1]Justus Liebigs Annalen der Chemie,1892,vol. 268,p. 61.

19
δ-chloro-γ-valerolactone [ No CAS ]
[ 10374-51-3 ]

References: [1]Chemische Berichte,1909,vol. 42,p. 1234.

20
(+-)-4,5-dibromo-valeronitrile [ No CAS ]
[ 10374-51-3 ]

References: [1]Patent: DE860203,1951, .

21
(+-)-5-bromo-4-hydroxy-valeric acid-lactone [ No CAS ]
[ 10374-51-3 ]

References: [1]Patent: DE860203,1951, .

22
[ 591-80-0 ]
Merrifield resin [ No CAS ]
[ 10374-51-3 ]

References: [1]Tetrahedron Letters,1997,vol. 38,p. 5153 - 5156.

23
[ 64-69-7 ]
[ 107-18-6 ]
[ 10374-51-3 ]

References: [1]Bulletin of the Chemical Society of Japan,2001,vol. 74,p. 1963 - 1970.

24
[ 52565-61-4 ]
[ 10374-51-3 ]

References: [1]European Journal of Organic Chemistry,2007,p. 437 - 444.
[2]Journal of Organic Chemistry,2007,vol. 72,p. 1526 - 1529.

25
[ 58839-90-0 ]
[ 10374-51-3 ]

References: [1]European Journal of Organic Chemistry,2007,p. 437 - 444.

26
[ 10374-51-3 ]
[ 136892-36-9 ]

References: [1]Journal of Medicinal Chemistry,1997,vol. 40,p. 168 - 180.

27
[ 10374-51-3 ]
tert-Butyl-(5-methoxy-tetrahydro-furan-2-ylmethoxy)-dimethyl-silane [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1997,vol. 40,p. 168 - 180.

28
[ 71834-72-5 ]
[ 10374-51-3 ]

References: [1]Journal of Medicinal Chemistry,1997,vol. 40,p. 168 - 180.

29
5-Diethoxymethyl-dihydro-furan-2-one [ No CAS ]
[ 10374-51-3 ]

References: [1]Journal of Medicinal Chemistry,1997,vol. 40,p. 168 - 180.

30
[ 10374-51-3 ]
aq. barium hydroxide solution [ No CAS ]
[ 78508-97-1 ]

References: [1]Journal of Organic Chemistry,1985,vol. 50,p. 2764 - 2766.

31
[ 10374-51-3 ]
aq. barium hydroxide solution [ No CAS ]
[ 96845-44-2 ]

References: [1]Journal of Organic Chemistry,1985,vol. 50,p. 2764 - 2766.

32
[ 10374-51-3 ]
aq. barium hydroxide solution [ No CAS ]
[ 96845-44-2 ]

References: [1]Journal of Organic Chemistry,1985,vol. 50,p. 2764 - 2766.

33
[ 10374-51-3 ]
aq. barium hydroxide solution [ No CAS ]
[ 96845-46-4 ]

References: [1]Journal of Organic Chemistry,1985,vol. 50,p. 2764 - 2766.

34
[ 10374-51-3 ]
aq. barium hydroxide solution [ No CAS ]
[ 96845-47-5 ]

References: [1]Journal of Organic Chemistry,1985,vol. 50,p. 2764 - 2766.

35
[ 10374-51-3 ]
aq. barium hydroxide solution [ No CAS ]
[ 96845-51-1 ]

References: [1]Journal of Organic Chemistry,1985,vol. 50,p. 2764 - 2766.

Historical Records

Technical Information

• Acyl Group Substitution • Appel Reaction • Bouveault-Blanc Reduction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Catalytic Hydrogenation • Chugaev Reaction • Complex Metal Hydride Reductions • Corey-Kim Oxidation • Dess-Martin Oxidation • Ester Cleavage • Hydride Reductions • Jones Oxidation • Martin's Sulfurane Dehydrating Reagent • Mitsunobu Reaction • Moffatt Oxidation • Oxidation of Alcohols by DMSO • Preparation of Alcohols • Preparation of Amines • Reactions of Alcohols • Reactions of Amines • Reactions with Organometallic Reagents • Ritter Reaction • Sharpless Olefin Synthesis • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Swern Oxidation

Related Functional Groups of
[ 10374-51-3 ]

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[ 10374-51-3 ]

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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 10374-51-3

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