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[ CAS No. 10344-42-0 ]

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Chemical Structure| 10344-42-0
Chemical Structure| 10344-42-0
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Product Details of [ 10344-42-0 ]

CAS No. :10344-42-0 MDL No. :MFCD13193322
Formula : C4HBrCl2N2 Boiling Point : 341.8°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :227.87 g/mol Pubchem ID :22030648
Synonyms :

Safety of [ 10344-42-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 10344-42-0 ]

  • Upstream synthesis route of [ 10344-42-0 ]
  • Downstream synthetic route of [ 10344-42-0 ]

[ 10344-42-0 ] Synthesis Path-Upstream   1~6

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YieldReaction ConditionsOperation in experiment
53% With ammonia In ethanol at 20℃; Autoclave 4-Bromo-3,6-dichloro-pyridazine (15.0 g, 65.8 mmol, prepared as described in WO 20081 16815) was dissolved in EtOH (73.1 mL) and introduced into an autoclave. At rt, gaseous NH3 (4.48 g, 263mmol) was introduced, and the reaction mixture was then stirred over night at reflux. The solution was concentrated in vacuo and the residue was triturated with EtOAc, the insoluble part was filtrated off, and the mother liquor evaporated to give the crude product. This was purified by Flash-Chromatography, eluting with cyclohexan /EtOAc 1/1 +2.5percent Et3N, to give the title compound as a pale brown solid (5.82g, 53percent). LCMS (method ZCQ13): Rt. 0.3min, 164/166/168 (M+H)
Reference: [1] Patent: WO2015/715, 2015, A1, . Location in patent: Page/Page column 123; 124
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Reference: [1] Patent: WO2007/115947, 2007, A1, . Location in patent: Page/Page column 30
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Reference: [1] Patent: WO2008/9700, 2008, A1, . Location in patent: Page/Page column 38-39
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Reference: [1] Patent: US6579875, 2003, B1,
[2] Patent: US6303605, 2001, B1,
[3] Patent: US6255305, 2001, B1,
[4] Patent: US6291460, 2001, B1,
[5] Patent: US6699859, 2004, B1,
[6] Patent: US6319924, 2001, B1,
[7] Heterocyclic Communications, 2015, vol. 21, # 4, p. 215 - 218
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Reference: [1] Patent: WO2007/115947, 2007, A1, . Location in patent: Page/Page column 30
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Reference: [1] Patent: WO2008/9700, 2008, A1, . Location in patent: Page/Page column 38-39
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