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Chemical Structure| 103360-96-9 Chemical Structure| 103360-96-9

Structure of 103360-96-9

Chemical Structure| 103360-96-9

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Product Details of [ 103360-96-9 ]

CAS No. :103360-96-9
Formula : C16H13FN2O4
M.W : 316.28
SMILES Code : O=C1N(C2=C(F)C=C(C(N3)=C2)OCC3=O)C(C4=C1CCCC4)=O

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Application In Synthesis of [ 103360-96-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 103360-96-9 ]

[ 103360-96-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 57684-71-6 ]
  • [ 103360-96-9 ]
  • [ 120102-11-6 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In ethanol; toluene; acetonitrile; STR64 A compound of 3-(chloromethyl)-isoxazole (1.2 g) was added dropwise at a temperature of 20 to 30 C. under stirring to a mixture of 7-fluoro-6-(4,5,6,7-tetrahydro-2H-isoindole-1,3-dion-2-yl)-2H-1,4-benzoxazin-3(4H)-one (3.16 g), acetonitrile (50 ml) and potassium carbonate (1.5 g). The reaction mixture was heated under refluxing for 3 hours, cooled to room temperature, and filtered. The filtrate was concentrated under a reduced pressure to dryness. The resultant residue was mixed with toluene (150 ml) to form a suspension, which was then filtered to remove the undissolved materials therefrom. The filtrate was concentrated under a reduced pressure so as to obtain a viscous material, which was thereafter dissolved in a minimum amount of ethanol. The ethanol solution was cooled to precipitate a crystalline product. This product was separated by filtration and dried, so that the aimed compound, i.e. 7-fluoro-4-(isoxazol-3-ylmethyl)-6-(4,5,6,7-tetrahydro-2H-isoindole-1,3-dion-2-yl)-2H-1,4-benzoxazin-3(4H)-one (3.3 g) was obtained. m.p. 206-210 C.
  • 2
  • [ 103361-99-5 ]
  • [ 103360-96-9 ]
 

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