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Chemical Structure| 103360-04-9 Chemical Structure| 103360-04-9

Structure of 103360-04-9

Chemical Structure| 103360-04-9

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Product Details of [ 103360-04-9 ]

CAS No. :103360-04-9
Formula : C7H6ClFO2S
M.W : 208.64
SMILES Code : O=S(CC1=CC=C(F)C=C1)(Cl)=O
MDL No. :MFCD01631930
InChI Key :UUQGWVIRPCRTSA-UHFFFAOYSA-N
Pubchem ID :2759108

Safety of [ 103360-04-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P261-P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 103360-04-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 103360-04-9 ]

[ 103360-04-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 103360-04-9 ]
  • [ 131922-05-9 ]
  • 1-[(4-fluorophenyl)methylsulfonyl]-3-(trifluoromethyl)piperazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
83% With triethylamine; In dichloromethane; at 0 - 20℃; 2-(Trifluoromethyl)-piperazine (2 g, 13 mmol) and TEA (2.17 ml, 15.6 mmol) were dissolved in DCM (30 ml). (4-fluorophenyl)methanesulfonyl chloride(2.71 g, 13 mmol) was added in small portions at 0 00 and the mixture was stirred at rt overnight. Water (45 ml) was added and the mixture extracted with DCM (2 x 80 ml). The combined organics were washed twice with brine, dried over Na2504, filtered and concentrated to give the product as a solid (3.5 g, 83%). MS ES+ m/z 327 [M+H].
83% With triethylamine; In dichloromethane; at 0 - 20℃; 2-(Trifluoromethyl)-piperazine (2 g, 13 mmol) and TEA (2.17 ml, 15.6 mmol) were dissolved in DCM (30 ml). (4-fluorophenyl)methanesulfonyl chloride (2.71 g, 13 mmol) was added in small portions at 0 C and the mixture was stirred at rt overnight. Water (45 ml) was added and the mixture extracted with DCM (2 x 80 ml). The combined organics were washed twice with brine, dried over Na2SO4, filtered and concentrated to give the product as a solid (3.5 g, 83%). MS ES+ m/z 327 [M+H]+.
  • 2
  • [ 103360-04-9 ]
  • [ 131922-05-9 ]
  • 1-(4-benzyloxy-6-tert-butoxy-2-pyridyl)-4-[(4-fluorophenyl)methylsulfonyl]-2-(trifluoromethyl)piperazine [ No CAS ]
 

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