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Chemical Structure| 1029052-74-1 Chemical Structure| 1029052-74-1

Structure of 1029052-74-1

Chemical Structure| 1029052-74-1

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5-((5-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine

CAS No.: 1029052-74-1

,98%

4.5 *For Research Use Only !

Cat. No.: A1461584 Purity: 98%

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    Product Details of [ 1029052-74-1 ]

    CAS No. :1029052-74-1
    Formula : C19H15ClN4O2S
    M.W : 398.87
    SMILES Code : NC1=NC=C(CC2=CN(S(=O)(C3=CC=CC=C3)=O)C4=NC=C(Cl)C=C42)C=C1

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    Application In Synthesis of [ 1029052-74-1 ]

    * All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

    • Downstream synthetic route of [ 1029052-74-1 ]

    [ 1029052-74-1 ] Synthesis Path-Downstream   1~1

    • 1
    • [ 1029052-74-1 ]
    • [ 159981-19-8 ]
    • [ 1029047-25-3 ]
    YieldReaction ConditionsOperation in experiment
    Step 1 - Synthesis of[5-(5-chloro-lH-pyrrolo[2,3-b]pyridin-3-ylmethyl)-pyridin-2-yl]-[6-(2,2,2- trifluoro-ethoxy)-pyridin-3-ylmethyl]-amine (P-0409):; [0254] To 5-(l -benzenesulfonyl-5-chloro-lH-pyrrolo[2,3-b]pyridin-3-ylmethyl)-pyridin-2- ylamine (599, 124.1 mg, 0.31 mmol, prepared as described in Example 29, Scheme 185) in ethanol (3.00 mL) and acetic acid (0.2 mL) were added 6-(2,2,2-trifluoro-ethoxy)-pyridine-3- carbaldehyde (603, 164.0 mg, 0.80 mmol) and silica supported cyanoborohydride (1.21 mmol/g, 0.700 g). The reaction was irradiated with microwave on 300 watts, 1000C for 150 minutes. To the reaction was added a solution of potassium hydroxide (9.0 M in water, 1.0 mL). The reaction was irradiated with microwave on 300 watts, 100 0C for 10 minutes. The reaction was poured into aqueous potassium carbonate and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated and purified by silica gel column chromatography eluting with 20% to 100% ethyl acetate in hexane to give the desired compound (P-0409, 10.6 mg, 7.6%). MS ESI) [M+H+]+ = 448.4.
     

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