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Chemical Structure| 10282-57-2 Chemical Structure| 10282-57-2

Structure of 10282-57-2

Chemical Structure| 10282-57-2

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Product Details of [ 10282-57-2 ]

CAS No. :10282-57-2
Formula : C13H10BrNO
M.W : 276.13
SMILES Code : O=C(NC1=CC=CC=C1)C2=CC=CC=C2Br
MDL No. :MFCD00449515

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Application In Synthesis of [ 10282-57-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10282-57-2 ]

[ 10282-57-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 10282-57-2 ]
  • [ 60940-34-3 ]
YieldReaction ConditionsOperation in experiment
Example 19: Synthesis of EbselenThe synthesis is outlined in Figure 16. To 30 ml of acetonitrile one adds 6 ml of aniline (6.13 grams) and then adds 6.5 ml of bromo-benzoylchloride (10.91 grams) to a <n="73"/>flask. One adds water/KOH (100 mM KOH final), filters off white precipitate and dries (96%). One places 4 grams, 14.5 mM, of the intermediate (MW 276.13), adds 1.2 grams of selenium, 12.6 mM, and approx 1.2 gram of NaBHt in 100 ml of ethanol, and stirs for an hour. After one hour, one filters off solids and washes with ethanol. One evaporates of the ethanol off under reduced pressure. One adds 2.0 grams of DTT (dithiothreitol, 15 mM) in 5 mL of water. One evaporates the solution to about 30 mL and one adds 200 mL of cold water. One vacuum filtrates the precipitate, and further washes with 200 mL of cold water. One dissolves the precipitate in chloroform and again washes with water. After combining organic layers, one distills off chloroform and, to provide the product, Ebselen, one crystallizes Ebselen in 2-butanone.
  • 2
  • [ 10282-57-2 ]
  • [ 128156-54-7 ]
  • [ 1086562-28-8 ]
 

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