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Chemical Structure| 10250-63-2 Chemical Structure| 10250-63-2

Structure of 10250-63-2

Chemical Structure| 10250-63-2

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Product Details of [ 10250-63-2 ]

CAS No. :10250-63-2
Formula : C13H14N2O2
M.W : 230.26
SMILES Code : O=C(C1=CC(C2=CC=CC=C2)=NN1C)OCC
MDL No. :MFCD03933288
InChI Key :JDJQHVJXMXXKFO-UHFFFAOYSA-N
Pubchem ID :4166529

Safety of [ 10250-63-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 10250-63-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 10250-63-2 ]
  • Downstream synthetic route of [ 10250-63-2 ]

[ 10250-63-2 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 10250-63-2 ]
  • [ 10250-64-3 ]
YieldReaction ConditionsOperation in experiment
93.1% With sodium hydroxide In methanol at 20℃; for 2 h; To a solution of 1-2 (247.5 mg, 1.1 mmol) in MeOH (5 mL) was added sodium hydroxide solution (10 mL, 4 M). The reaction mixture was stirred at room temperature for 2 hours and concentrated under reduced pressure to remove MeOH. The aqueous phase was acidified with aqueous HCl (1 M) till pH=3 and the mixture was extracted with EtOAc, dried with anhydrous Na2SO4, filtered and concentrated to give the crude product. The crude product was purified by silica gel chromatography eluted to give product 1-3 (207.0 mg, 93.1percent). MS m/z [ESI]: 203.1 [M+1].
References: [1] Patent: US2018/271846, 2018, A1, . Location in patent: Paragraph 0176; 0180; 0181.
[2] Patent: EP1216980, 2002, A1, .
[3] Patent: WO2009/12482, 2009, A2, . Location in patent: Page/Page column 95.
[4] Patent: WO2004/18428, 2004, A1, . Location in patent: Page 92.
  • 2
  • [ 10250-63-2 ]
  • [ 10250-64-3 ]
References: [1] Patent: US6492401, 2002, B1, .
 

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