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Chemical Structure| 10250-62-1 Chemical Structure| 10250-62-1

Structure of 10250-62-1

Chemical Structure| 10250-62-1

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Product Details of [ 10250-62-1 ]

CAS No. :10250-62-1
Formula : C12H12N2O2
M.W : 216.24
SMILES Code : O=C(C1=CC(C2=CC=CC=C2)=NN1C)OC
MDL No. :MFCD02323762

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Application In Synthesis of [ 10250-62-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 10250-62-1 ]
  • Downstream synthetic route of [ 10250-62-1 ]

[ 10250-62-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 10250-62-1 ]
  • [ 10250-64-3 ]
YieldReaction ConditionsOperation in experiment
95%
Stage #1: With lithium hydroxide; water In ethanol at 50℃;
Stage #2: With hydrogenchloride In water
Methyl l-methyl-3-phenyl-lH-pyrazole-5-carboxylate (1.0Og, 6.23 iranol) was dissolved in EtOH (10 inL) and water (10 mL) then lithium hydroxide monohydrate (0.582 g, 13.87 mmol) was added. The mixture was stirred at 500C until complete by HPLC. The mixture was concentrated to a residue, water was added and the mixture was extracted with DCM. The aqueous layer was acidified using IN HCl and the resulting solid was filtered and dried under high vacuum to give l-methyl-3-phenyl-lH-pyrazole- 5-carboxylic acid (0.887 g, 95percent) as a white solid; m/z (APCI pos) 203 (100percent) (M+H) .
References: [1] Patent: WO2008/11131, 2008, A2, . Location in patent: Page/Page column 260.
[2] Chemische Berichte, 1933, vol. 66, p. 1690,1692.
[3] Patent: EP1176140, 2002, A1, . Location in patent: Page 49 - 50.
 

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