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Chemical Structure| 1021186-08-2 Chemical Structure| 1021186-08-2

Structure of 1021186-08-2

Chemical Structure| 1021186-08-2

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Product Details of [ 1021186-08-2 ]

CAS No. :1021186-08-2
Formula : C18H29BClNO2
M.W : 337.69
SMILES Code : CC1(C)C(C)(C)OB(C2=CC(CN3CCCCC3)=CC=C2)O1.[H]Cl
MDL No. :MFCD06657902

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Application In Synthesis of [ 1021186-08-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1021186-08-2 ]

[ 1021186-08-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 52333-42-3 ]
  • [ 1021186-08-2 ]
  • [ 1225279-44-6 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; water; at 120.0℃; for 0.333333h;Sealed tube; Microwave irradiation; EXAMPLE 427-[3-(Piperidin-l-ylmethyl)phenyllpyridor2,3-Z)lpyrazine, bis(acetic acid) saltIntermediate 19 (41 mg, 0.21 mmol), 3-(piperidin-l-ylmethyl)phenylboronic acid pinacol ester hydrochloride (70 mg, 0.21 mmol), 2M aqueous sodium carbonate solution (0.3 mL, 0.6 mmol) and Pd(PPh3)4 (7 mg, 0.006 mmol) in DME (0.6 mL) were heated to 1200C in a sealed tube, under microwave irradiation, for 20 minutes. After cooling, the organic phase was concentrated in vacuo and the residue was purified by preparative HPLC to give the title compound (68 mg, 76%) as a beige solid. deltaH (CDCl3) 9.49 (d, IH), 9.08 (d, IH), 8.99 (d, IH), 8.65 (d, IH), 7.82 (s, IH), 7.73 (d, IH), 7.55 (t, IH), 7.49 (d, IH), 3.84 (s, 2H), 2.59-2.75 (m, 4H), 2.09 (s, 6H), 1.65-1.79 (m, 4H), 1.43-1.60 (m, 2H). LCMS (ES+) 305 (M+H)+, RT 2.02 minutes.
 

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