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Chemical Structure| 1013427-04-7 Chemical Structure| 1013427-04-7

Structure of 1013427-04-7

Chemical Structure| 1013427-04-7

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Product Details of [ 1013427-04-7 ]

CAS No. :1013427-04-7
Formula : C11H14IN3
M.W : 315.15
SMILES Code : CC(C1=CC(C)=NC2=C(I)C(C)=NN12)C
MDL No. :MFCD18073965

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Application In Synthesis of [ 1013427-04-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1013427-04-7 ]

[ 1013427-04-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 848841-68-9 ]
  • [ 1013427-04-7 ]
  • 3-(4-chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
62% With caesium carbonate; triphenylphosphine;palladium diacetate; copper(l) iodide; In N,N-dimethyl-formamide; at 125.0℃; for 16.0h; Alternate Preparation from Preparation 6: Combine 7-(l-ethyl-propyl)-3-iodo-2,5-dimethyl-pyrazolo[l,5-alpha]pyrimidine, (9 g,26.2 mmol) and <strong>[848841-68-9]4-chloro-2-morpholino-thiazole</strong> (7.5 g, 36.7 mmol) in dimethylformamide (90 mL) previously degassed with nitrogen. Add cesium carbonate (17.8 g, 55 mmol), copper iodide (250 mg, 1.31 mmol), triphenylphosphine (550 mg, 2.09 mmol) and palladium acetate (117 mg, 0.52 mmol). Heat the mixture to 125 0C for 16 h and then cool to 22 0C. Add water (900 mL) and extract with methyl-?-butyl ether (3 x 200 mL). Combine the organic portions and evaporate the solvent. Purify by silica gel chromatography eluting with hexanes/ethyl acetate (4/1) to afford the title compound (6.4 g, 62%). ES/MS m/z (35Cl) 420 (M+l)+.
 

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