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Chemical Structure| 1009303-44-9 Chemical Structure| 1009303-44-9

Structure of 1009303-44-9

Chemical Structure| 1009303-44-9

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Product Details of [ 1009303-44-9 ]

CAS No. :1009303-44-9
Formula : C17H22ClN5O2
M.W : 363.84
SMILES Code : ClC1=NC2=NC(N3[C@@H](C)COCC3)=NC(N4[C@@H](C)COCC4)=C2C=C1
MDL No. :MFCD18782759

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Application In Synthesis of [ 1009303-44-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1009303-44-9 ]

[ 1009303-44-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1009303-44-9 ]
  • [ 1009303-77-8 ]
  • AZD8055 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; toluene; at 140.0℃; for 0.5h;Microwave radiation; The appropriate chloro-substrate (1 equiv) was dissolved in a toluene/ethanol (1:1) solution (0.02 M). Sodium carbonate (2 equiv) and the appropriate pinacolate boron ester or boronic acid (1 equiv) were then added followed by tetrakis(triphenylphosphine) palladium0 (0.1 equiv). The reaction vessel was sealed and the mixture exposed to microwave radiation (140 0C, medium absorption setting) for 30 minutes. Upon completion the samples were filtered through a silica cartridge, washed with EtOAc and then concentrated in vacuo. The crude residue was then purified by preparative HPLC to give the desired products.
 

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